9BNR
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![BU of 9bnr by Molmil](/molmil-images/mine/9bnr) | 4-(2-isothiocyanatoethyl)benzenesulfonamide complexed with Macrophage Migration Inhibitory Factor | Descriptor: | Macrophage migration inhibitory factor, N-[2-(4-sulfamoylphenyl)ethyl]methanethioamide, SULFATE ION | Authors: | Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A. | Deposit date: | 2024-05-02 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Chemmedchem, 2024
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9C6N
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![BU of 9c6n by Molmil](/molmil-images/mine/9c6n) | ARP module of the human TIP60 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | Deposit date: | 2024-06-07 | Release date: | 2024-08-21 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9ASB
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![BU of 9asb by Molmil](/molmil-images/mine/9asb) | Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs | Descriptor: | (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | Deposit date: | 2024-02-24 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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9EQ0
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![BU of 9eq0 by Molmil](/molmil-images/mine/9eq0) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGJG12 | Descriptor: | Casein kinase II subunit alpha, SULFATE ION, ~{N}-[4-[(3-chloranyl-4-phenyl-phenyl)methylamino]butyl]isoquinoline-5-sulfonamide | Authors: | Kraemer, A, Greco, F, Gerninghaus, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9EPV
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![BU of 9epv by Molmil](/molmil-images/mine/9epv) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC333 | Descriptor: | 1,2-ETHANEDIOL, 5-[[2-[(3-chloranyl-4-phenyl-phenyl)methylamino]-7-azaspiro[3.5]nonan-7-yl]sulfonyl]-1,3-dimethyl-benzimidazol-2-one, Casein kinase II subunit alpha, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9EPY
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![BU of 9epy by Molmil](/molmil-images/mine/9epy) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3330 | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9FZD
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9EQ1
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![BU of 9eq1 by Molmil](/molmil-images/mine/9eq1) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGJM24 | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | Authors: | Kraemer, A, Greco, F, Moeckel, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9EPZ
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![BU of 9epz by Molmil](/molmil-images/mine/9epz) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3337 | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9EPW
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![BU of 9epw by Molmil](/molmil-images/mine/9epw) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3336 | Descriptor: | Casein kinase II subunit alpha, SULFATE ION, ~{N}-[(3-chloranyl-4-phenyl-phenyl)methyl]-2-[1-(3-methylquinolin-8-yl)sulfonylpiperidin-4-yl]ethanamine | Authors: | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-03-20 | Release date: | 2024-05-01 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9C4B
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![BU of 9c4b by Molmil](/molmil-images/mine/9c4b) | Second BAF53a of the human TIP60 complex | Descriptor: | Actin-like protein 6A | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | Deposit date: | 2024-06-03 | Release date: | 2024-08-14 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9EU5
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![BU of 9eu5 by Molmil](/molmil-images/mine/9eu5) | SSX structure of Autotaxin at room temperature | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | Authors: | Eymery, M.C, McCarthy, A.A, Foos, N, Basu, S. | Deposit date: | 2024-03-27 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry. Iucrj, 2024
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9ICD
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![BU of 9icd by Molmil](/molmil-images/mine/9icd) | CATALYTIC MECHANISM OF NADP+-DEPENDENT ISOCITRATE DEHYDROGENASE: IMPLICATIONS FROM THE STRUCTURES OF MAGNESIUM-ISOCITRATE AND NADP+ COMPLEXES | Descriptor: | ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Hurley, J.H, Dean, A.M, Koshland Jr, D.E, Stroud, R.M. | Deposit date: | 1991-07-29 | Release date: | 1991-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry, 30, 1991
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9C57
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![BU of 9c57 by Molmil](/molmil-images/mine/9c57) | Reconstituted P400 Subcomplex of the human TIP60 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | Deposit date: | 2024-06-05 | Release date: | 2024-08-21 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9C47
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![BU of 9c47 by Molmil](/molmil-images/mine/9c47) | TRRAP module of the human TIP60 complex | Descriptor: | E1A-binding protein p400, Transformation/transcription domain-associated protein | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | Deposit date: | 2024-06-03 | Release date: | 2024-08-14 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9ENT
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![BU of 9ent by Molmil](/molmil-images/mine/9ent) | SSX structure of Autotaxin in cryogenic conditions | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | Authors: | Eymery, M.C, McCarthy, A.A, Foos, N, Basu, S. | Deposit date: | 2024-03-13 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry. Iucrj, 2024
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9C62
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![BU of 9c62 by Molmil](/molmil-images/mine/9c62) | P400 subcomplex of the native human TIP60 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | Deposit date: | 2024-06-07 | Release date: | 2024-08-21 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (5.28 Å) | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9BIV
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![BU of 9biv by Molmil](/molmil-images/mine/9biv) | |
9AAT
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![BU of 9aat by Molmil](/molmil-images/mine/9aat) | |
966C
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![BU of 966c by Molmil](/molmil-images/mine/966c) | CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID | Descriptor: | CALCIUM ION, MMP-1, N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE, ... | Authors: | Lovejoy, B, Welch, A, Carr, S, Luong, C, Broka, C, Hendricks, R.T, Campbell, J, Walker, K, Martin, R, Van Wart, H, Browner, M.F. | Deposit date: | 1998-08-07 | Release date: | 1999-08-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors. Nat.Struct.Biol., 6, 1999
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9EQM
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![BU of 9eqm by Molmil](/molmil-images/mine/9eqm) | Crystal structure of pVHL:EloB:EloC in complex with MP-1-21 | Descriptor: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[trans-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | Deposit date: | 2024-03-21 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity. Bioorg.Med.Chem.Lett., 110, 2024
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9CGT
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![BU of 9cgt by Molmil](/molmil-images/mine/9cgt) | STRUCTURE OF CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED WITH A THIO-MALTOPENTAOSE | Descriptor: | CALCIUM ION, PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-1-thio-alpha-D-glucopyranose | Authors: | Schmidt, A.K, Schulz, G.E. | Deposit date: | 1998-09-27 | Release date: | 1998-10-14 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Substrate binding to a cyclodextrin glycosyltransferase and mutations increasing the gamma-cyclodextrin production. Eur.J.Biochem., 255, 1998
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9EZG
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![BU of 9ezg by Molmil](/molmil-images/mine/9ezg) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((4-((2-aminoethyl)(ethyl)amino)-3-(4H-1,2,4-triazol-4-yl)phenyl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | Descriptor: | 1,2-ETHANEDIOL, 5-[[4-[2-azanylethyl(ethyl)amino]-3-(1,2,4-triazol-4-yl)phenyl]amino]-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Casein kinase II subunit alpha, ... | Authors: | Kraemer, A, Ong, H.W, Yang, X, Brown, J.W, Chang, E, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2024-04-12 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting beta-Coronavirus Replication. J.Med.Chem., 67, 2024
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7PD3
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![BU of 7pd3 by Molmil](/molmil-images/mine/7pd3) | Structure of the human mitoribosomal large subunit in complex with NSUN4.MTERF4.GTPBP7 and MALSU1.L0R8F8.mt-ACP | Descriptor: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | Authors: | Chandrasekaran, V, Desai, N, Burton, N.O, Yang, H, Price, J, Miska, E.A, Ramakrishnan, V. | Deposit date: | 2021-08-04 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Visualizing formation of the active site in the mitochondrial ribosome. Elife, 10, 2021
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9AVG
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![BU of 9avg by Molmil](/molmil-images/mine/9avg) | Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs | Descriptor: | (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | Deposit date: | 2024-03-02 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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