5HLI
| Structure of Disulfide formed AbfR | 分子名称: | CHLORIDE ION, COPPER (II) ION, MarR family transcriptional regulator | 著者 | Liu, G, Liu, X, Gan, J, Yang, C.-G. | 登録日 | 2016-01-15 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc., 139, 2017
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5HLH
| Crystal structure of the overoxidized AbfR bound to DNA | 分子名称: | DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator | 著者 | Liu, G, Liu, X, Gan, J, Yang, C.-G. | 登録日 | 2016-01-15 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc., 139, 2017
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7CJM
| SARS CoV-2 PLpro in complex with GRL0617 | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, ZINC ION | 著者 | Fu, Z, Huang, H. | 登録日 | 2020-07-11 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. Nat Commun, 12, 2021
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6PYR
| Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one) | 分子名称: | (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Lesburg, C.A, Augustin, M.A. | 登録日 | 2019-07-30 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow. Bioorg.Med.Chem.Lett., 29, 2019
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6PYS
| Human PI3Kalpha in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one) | 分子名称: | (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one, GLYCEROL, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Lesburg, C.A, Augustin, M.A. | 登録日 | 2019-07-30 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow. Bioorg.Med.Chem.Lett., 29, 2019
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6PYU
| Human PI3Kdelta in complex with Compound 4-2 ((3S)-1'-(cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'-pyrrolidin]-2(1H)-one) | 分子名称: | (3S)-1'-(cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'-pyrrolidin]-2(1H)-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Lesburg, C.A, Augustin, M.A. | 登録日 | 2019-07-30 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow. Bioorg.Med.Chem.Lett., 29, 2019
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8DQL
| CryoEM structure of IglD | 分子名称: | Secretion system protein | 著者 | Liu, X, Clemens, D, Lee, B, Yang, X, Zhou, H, Horwitz, M. | 登録日 | 2022-07-19 | 公開日 | 2022-08-17 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System. Mbio, 13, 2022
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5KNN
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6IM4
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6IST
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6JM5
| Crystal structure of TBC1D23 C terminal domain | 分子名称: | SODIUM ION, TBC1 domain family member 23 | 著者 | Sun, Q, Huang, W. | 登録日 | 2019-03-07 | 公開日 | 2019-10-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proc.Natl.Acad.Sci.USA, 116, 2019
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6K0Y
| Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor | 分子名称: | 1,2-ETHANEDIOL, Antibody Heavy Chain, Antibody Light Chain, ... | 著者 | Liu, J.X, Wang, G.Q. | 登録日 | 2019-05-08 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor. Sci Rep, 9, 2019
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3SV1
| Crystal structure of APP peptide bound rat Mint2 PARM | 分子名称: | Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein | 著者 | Shen, Y, Long, J, Yan, X, Xie, X. | 登録日 | 2011-07-12 | 公開日 | 2012-07-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Open-closed motion of Mint2 regulates APP metabolism J Mol Cell Biol, 5, 2013
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4MFI
| Crystal structure of Mycobacterium tuberculosis UgpB | 分子名称: | Sn-glycerol-3-phosphate ABC transporter substrate-binding protein UspB | 著者 | Jiang, D, Bartlam, M, Rao, Z. | 登録日 | 2013-08-28 | 公開日 | 2014-07-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine Febs J., 281, 2014
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3SUZ
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8HGK
| Crystal structure of human ClpP in complex with ZK53 | 分子名称: | 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | 著者 | Yang, C.-G, Gan, J.H, Zhou, L.-L. | 登録日 | 2022-11-14 | 公開日 | 2023-09-27 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma. Nat Commun, 14, 2023
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6U9K
| MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153) | 分子名称: | 5'-([(3S)-3-amino-3-carboxypropyl]{[1-(3,3-diphenylpropyl)azetidin-3-yl]methyl}amino)-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6U9N
| MLL1 SET N3861I/Q3867L bound to inhibitor 14 (TC-5139) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(4-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6U9R
| MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6U9M
| MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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5C90
| Staphylococcus aureus ClpP mutant - Y63A | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit | 著者 | Ye, F, Liu, H, Zhang, J, Gan, J, Yang, C.-G. | 登録日 | 2015-06-26 | 公開日 | 2016-05-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure Acs Chem.Biol., 11, 2016
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7CYV
| Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD) | 分子名称: | Spike protein S1, The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Li, Y, Li, T, Lai, Y, Cai, H, Yao, H, Li, D. | 登録日 | 2020-09-04 | 公開日 | 2021-09-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. Embo Mol Med, 13, 2021
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2Q8S
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2QFJ
| Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE | 分子名称: | DNA (5'-D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DTP*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3'), FBP-interacting repressor | 著者 | Crichlow, G.V, Yang, Y, Fan, C, Lolis, E, Braddock, D. | 登録日 | 2007-06-27 | 公開日 | 2008-03-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition EMBO J., 27, 2007
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2QSE
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