5YWO
 
 | | Structure of JEV-2F2 Fab complex | | 分子名称: | 2F2 heavy chain, 2F2 light chain, JEV E protein, ... | | 著者 | Qiu, X, Lei, Y.F, Yang, P, Gao, Q, Wang, N, Cao, L, Yuan, S, Wang, X, Xu, Z.K, Rao, Z. | | 登録日 | 2017-11-29 | | 公開日 | 2018-03-21 | | 最終更新日 | 2018-09-12 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
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5YWP
 | | JEV-2H4 Fab complex | | 分子名称: | 2H4 heavy chain, 2H4 light chain, JEV E protein, ... | | 著者 | Qiu, X.D, Lei, Y.F, Yang, P, Gao, Q, WANG, N, Cao, L, Yuan, S, Wang, X.X, Xu, Z.K, Rao, Z.H. | | 登録日 | 2017-11-29 | | 公開日 | 2018-05-02 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
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5YWF
 | | Crystal structure of 2H4 Fab | | 分子名称: | 2H4 heavy chain, 2H4 light chain | | 著者 | Qiu, X, Lei, Y, Yang, P, Gao, Q, Wang, N, Cao, L, Wang, X, Xu, Z.K, Rao, Z. | | 登録日 | 2017-11-29 | | 公開日 | 2018-03-21 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
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5ZVS
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5ZVT
 | | Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly | | 分子名称: | C-terminus of outer capsid protein VP5, Core protein VP6, MYRISTIC ACID, ... | | 著者 | Liu, H, Fang, Q, Cheng, L. | | 登録日 | 2018-05-12 | | 公開日 | 2018-07-04 | | 最終更新日 | 2018-07-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6AI6
 | | Crystal structure of SpCas9-NG | | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), ... | | 著者 | Nishimasu, H, Hirano, S, Ishitani, R, Nureki, O. | | 登録日 | 2018-08-21 | | 公開日 | 2018-10-31 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Engineered CRISPR-Cas9 nuclease with expanded targeting space
Science, 361, 2018
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8H1J
 | | Cryo-EM structure of the TnpB-omegaRNA-target DNA ternary complex | | 分子名称: | Non-target strand, RNA-guided DNA endonuclease TnpB, Target strand, ... | | 著者 | Nakagawa, R, Hirano, H, Omura, S, Nureki, O. | | 登録日 | 2022-10-03 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structure of the transposon-associated TnpB enzyme.
Nature, 616, 2023
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8HL9
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8IMF
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8IME
 | | Human cGAS catalytic domain bound with baicalin | | 分子名称: | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, Cyclic GMP-AMP synthase, ZINC ION | | 著者 | Zhao, W.F, Xu, Y.C. | | 登録日 | 2023-03-06 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Discovery of novel cGAS inhibitors based on natural flavonoids.
Bioorg.Chem., 140, 2023
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8IMG
 | | Human cGAS catalytic domain bound with C20 | | 分子名称: | 2-[2-hydroxy-2-oxoethyl-[3-(7-methoxy-4-methyl-2-oxidanylidene-chromen-3-yl)propanoyl]amino]ethanoic acid, Cyclic GMP-AMP synthase, ZINC ION | | 著者 | Zhao, W.F, Li, J.M, Xu, Y.C. | | 登録日 | 2023-03-06 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of novel cGAS inhibitors based on natural flavonoids.
Bioorg.Chem., 140, 2023
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8IJ1
 | | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | 著者 | Dai, Z, Liang, L, Yin, Y.X. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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8JE1
 | | An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | 著者 | Dai, Z, Liang, L, Yin, Y.X. | | 登録日 | 2023-05-15 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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8JE2
 | | Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN | | 分子名称: | Cullin-2, Elongin-B, Elongin-C, ... | | 著者 | Dai, Z, Liang, L, Yin, Y.X. | | 登録日 | 2023-05-15 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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7FJF
 | | Cryo-EM structure of a membrane protein(CS) | | 分子名称: | CHOLEST-5-EN-3-YL HYDROGEN SULFATE, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | 著者 | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | 登録日 | 2021-08-03 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7FJE
 | | Cryo-EM structure of a membrane protein(LL) | | 分子名称: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | 著者 | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | 登録日 | 2021-08-03 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7FJD
 | | Cryo-EM structure of a membrane protein(WT) | | 分子名称: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | 著者 | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | 登録日 | 2021-08-03 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7CYA
 | | Saimiri boliviensis boliviensis galectin-13 with lactose | | 分子名称: | Galectin, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Su, J. | | 登録日 | 2020-09-03 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Actin binding to galectin-13/placental protein-13 occurs independently of the galectin canonical ligand-binding site.
Glycobiology, 31, 2021
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7CYB
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7E24
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7E28
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7EEI
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7JRN
 | | Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617 | | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, SULFATE ION, ... | | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | | 登録日 | 2020-08-12 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay.
Acs Cent.Sci., 7, 2021
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7VTI
 | | Crystal structure of the Cas13bt3-crRNA binary complex | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | | 著者 | Nakagawa, R, Takeda, N.S, Tomita, A, Hirano, H, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | | 登録日 | 2021-10-29 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structure and engineering of the minimal type VI CRISPR-Cas13bt3.
Mol.Cell, 82, 2022
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7VSP
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