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5F6E
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BU of 5f6e by Molmil
Crystal Structure of human Ubc9 (K48A/K49A/E54A)
分子名称: 1,2-ETHANEDIOL, SUMO-conjugating enzyme UBC9
著者Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S.
登録日2015-12-05
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
Angew.Chem.Int.Ed.Engl., 55, 2016
5F6U
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BU of 5f6u by Molmil
Crystal Structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 8 (JSS190B146)
分子名称: SUMO-conjugating enzyme UBC9, ethyl 3-[4-(2-hydroxyphenyl)-3-oxidanyl-phenyl]propanoate
著者Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S.
登録日2015-12-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.552 Å)
主引用文献Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
Angew.Chem.Int.Ed.Engl., 55, 2016
5F6X
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BU of 5f6x by Molmil
Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from cocktail screen)
分子名称: 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9
著者Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S.
登録日2015-12-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
Angew.Chem.Int.Ed.Engl., 55, 2016
5F6Y
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BU of 5f6y by Molmil
Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole)
分子名称: 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9
著者Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S.
登録日2015-12-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
Angew.Chem.Int.Ed.Engl., 55, 2016
1XM5
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BU of 1xm5 by Molmil
Crystal structure of metal-dependent hydrolase ybeY from E. coli, Pfam UPF0054
分子名称: Hypothetical UPF0054 protein ybeY, NICKEL (II) ION
著者Fedorov, A.A, Fedorov, E.V, Shi, W, Ramagopal, U.A, Thirumuruhan, R, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2004-10-01
公開日2004-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The ybeY protein from Escherichia coli is a metalloprotein.
Acta Crystallogr.,Sect.F, 61, 2005
3TPX
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BU of 3tpx by Molmil
Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor
分子名称: ACETATE ION, CHLORIDE ION, D-peptide inhibitor DPMI-delta, ...
著者Wu, X, Pazgier, M.
登録日2011-09-08
公開日2012-06-20
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
J.Med.Chem., 55, 2012
3IWY
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BU of 3iwy by Molmil
Crystal structure of human MDM2 complexed with D-peptide (12 residues)
分子名称: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2
著者Pazgier, M, Lu, W.
登録日2009-09-03
公開日2010-04-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
5L19
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BU of 5l19 by Molmil
Crystal Structure of a human FasL mutant
分子名称: SULFATE ION, Tumor necrosis factor ligand superfamily member 6, ZINC ION
著者Liu, W, Bonanno, J.B, Almo, S.C.
登録日2016-07-28
公開日2016-09-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24, 2016
5L36
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BU of 5l36 by Molmil
Crystal Structure of a human FasL mutant in complex with human DcR3
分子名称: SODIUM ION, Tumor necrosis factor ligand superfamily member 6, Tumor necrosis factor receptor superfamily member 6B
著者Liu, W, Bonanno, J.B, Almo, S.C.
登録日2016-08-03
公開日2016-09-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24, 2016
4DU0
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BU of 4du0 by Molmil
Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)
分子名称: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
著者Wu, X, Lu, W, Pazgier, M.
登録日2012-02-21
公開日2012-04-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1
J.Biol.Chem., 287, 2012
4EYC
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BU of 4eyc by Molmil
Crystal structure of the cathelin-like domain of human cathelicidin LL-37 (hCLD)
分子名称: Cathelicidin antimicrobial peptide
著者Pazgier, M, Pozharski, E, Toth, E, Lu, W.
登録日2012-05-01
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37.
Biochemistry, 52, 2013
3MB8
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BU of 3mb8 by Molmil
Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, GLYCEROL, PHOSPHATE ION, ...
著者Ho, M, Almo, S.C, Schramm, V.L.
登録日2010-03-25
公開日2011-04-06
最終更新日2022-10-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase.
Eukaryot Cell, 13, 2014
4RXZ
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BU of 4rxz by Molmil
Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
分子名称: 12-MER PEPTIDE INHIBITOR, Protein Mdm4
著者Pazgier, M, Gohain, N, Tolbert, W.D.
登録日2014-12-12
公開日2015-07-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural basis of how stress-induced MDMX phosphorylation activates p53.
Oncogene, 35, 2016
4LBF
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BU of 4lbf by Molmil
Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant
分子名称: GLYCEROL, Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LB1
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BU of 4lb1 by Molmil
Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant
分子名称: Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LBB
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BU of 4lbb by Molmil
Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant
分子名称: CHLORIDE ION, Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.719 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LB7
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BU of 4lb7 by Molmil
Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant.
分子名称: Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
8HKE
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BU of 8hke by Molmil
dsRNA transporter
分子名称: RNA (37-MER), Systemic RNA interference defective protein 1, ZINC ION
著者Jiang, D.H, Zhang, J.T.
登録日2022-11-25
公開日2023-11-29
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Structural insights into double-stranded RNA recognition and transport by SID-1.
Nat.Struct.Mol.Biol., 2024
8HIP
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BU of 8hip by Molmil
dsRNA transporter
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Systemic RNA interference defective protein 1, ZINC ION, ...
著者Jiang, D.H, Zhang, J.T.
登録日2022-11-21
公開日2023-11-29
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Structural insights into double-stranded RNA recognition and transport by SID-1.
Nat.Struct.Mol.Biol., 2024
8J6O
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BU of 8j6o by Molmil
transport T2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Green fluorescent protein (Fragment),SID1 transmembrane family member 2, ...
著者Jiang, D.H, Zhang, J.T.
登録日2023-04-26
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structural insights into double-stranded RNA recognition and transport by SID-1.
Nat.Struct.Mol.Biol., 2024
8J6M
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BU of 8j6m by Molmil
SIDT1 protein
分子名称: CHOLESTEROL, Green fluorescent protein,SID1 transmembrane family member 1, OLEIC ACID, ...
著者Zhang, J.T, Jiang, D.H.
登録日2023-04-26
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Structural insights into double-stranded RNA recognition and transport by SID-1.
Nat.Struct.Mol.Biol., 2024
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