3MB8

Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H

Summary for 3MB8

Entry DOI	10.2210/pdb3mb8/pdb
Descriptor	Purine nucleoside phosphorylase, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	pnp, purine nucleoside phosphorylase, immucillin h, immh, transferase
Biological source	Toxoplasma gondii
Total number of polymer chains	2
Total formula weight	62258.84
Authors	Ho, M.,Almo, S.C.,Schramm, V.L. (deposition date: 2010-03-25, release date: 2011-04-06, Last modification date: 2022-10-05)
Primary citation	Donaldson, T.M.,Cassera, M.B.,Ho, M.C.,Zhan, C.,Merino, E.F.,Evans, G.B.,Tyler, P.C.,Almo, S.C.,Schramm, V.L.,Kim, K. Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase. Eukaryot Cell, 13:572-579, 2014 Cited by PubMed: 24585883 DOI: 10.1128/EC.00308-13 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation