3MB8

Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Purine nucleoside phosphorylase	polymer	279	30584.0	2	UniProt (Q2HXR2) Pfam (PF01048)	Toxoplasma gondii
2	C, G (A, B)	1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL	non-polymer		266.3	2	Chemie (IMH)
3	D, H (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	E, F, I, J (A, B)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	K, L (A, B)	water	water		18.0	340	Chemie (HOH)

Sequence modifications

A, B: 4 - 250 (UniProt: Q2HXR2)

PDB	External Database	Details
Met 1	-	expression tag
Pro 2	-	expression tag
Leu 3	-	expression tag
Val 236	Ile 233	SEE REMARK 999
Lys 251	-	expression tag
Gly 252	-	expression tag
Glu 253	-	expression tag
Phe 254	-	expression tag
Glu 255	-	expression tag
Ala 256	-	expression tag
Tyr 257	-	expression tag
Val 258	-	expression tag
Glu 259	-	expression tag
Gln 260	-	expression tag
Lys 261	-	expression tag
Leu 262	-	expression tag
Ile 263	-	expression tag
Ser 264	-	expression tag
Glu 265	-	expression tag
Glu 266	-	expression tag
Asp 267	-	expression tag
Leu 268	-	expression tag
Asn 269	-	expression tag
Ser 270	-	expression tag
Ala 271	-	expression tag
Val 272	-	expression tag
Asp 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61168.0
Non-Polymers*	Number of molecules	8
	Total formula weight	1090.8
All*	Total formula weight	62258.8

*Water molecules are not included.