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3MB8

Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004731molecular_functionpurine-nucleoside phosphorylase activity
A0004850molecular_functionuridine phosphorylase activity
A0005829cellular_componentcytosol
A0006218biological_processuridine catabolic process
A0009116biological_processnucleoside metabolic process
A0016757molecular_functionglycosyltransferase activity
B0003824molecular_functioncatalytic activity
B0004731molecular_functionpurine-nucleoside phosphorylase activity
B0004850molecular_functionuridine phosphorylase activity
B0005829cellular_componentcytosol
B0006218biological_processuridine catabolic process
B0009116biological_processnucleoside metabolic process
B0016757molecular_functionglycosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE IMH A 280
ChainResidue
AILE71
APRO213
ATRP216
APO4281
AHOH295
AHOH312
AHOH313
BHIS12
BGOL283
AARG93
ATHR96
ACYS97
AGLY98
AASP186
AMET187
AGLU188
AASP210

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 A 281
ChainResidue
AGLY28
AARG32
AARG93
AGLY95
ATHR96
AIMH280
BARG50

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 282
ChainResidue
AARG14
AARG16
AASP19
ALEU46
AHOH319

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 283
ChainResidue
APRO11
AARG14
AASN49
AARG50
AHOH360
BTYR221
BALA223
BIMH280
BHOH321

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE IMH B 280
ChainResidue
AHIS12
AGOL283
BILE71
BARG93
BTHR96
BCYS97
BGLY98
BPHE165
BASP186
BMET187
BGLU188
BASP210
BPRO213
BTRP216
BPO4281
BHOH289
BHOH305
BHOH318

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 B 281
ChainResidue
AARG50
BGLY28
BARG32
BARG93
BGLY95
BTHR96
BIMH280

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 282
ChainResidue
BARG14
BARG16
BASP19
BLEU46
BHOH297

site_idAC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 283
ChainResidue
ATYR221
AALA223
AIMH280
AHOH333
BPRO11
BARG14
BASN49
BARG50
BHOH322

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PDB entries from 2024-11-06

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