3MB8
Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0004850 | molecular_function | uridine phosphorylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006218 | biological_process | uridine catabolic process |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0004850 | molecular_function | uridine phosphorylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006218 | biological_process | uridine catabolic process |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE IMH A 280 |
Chain | Residue |
A | ILE71 |
A | PRO213 |
A | TRP216 |
A | PO4281 |
A | HOH295 |
A | HOH312 |
A | HOH313 |
B | HIS12 |
B | GOL283 |
A | ARG93 |
A | THR96 |
A | CYS97 |
A | GLY98 |
A | ASP186 |
A | MET187 |
A | GLU188 |
A | ASP210 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 A 281 |
Chain | Residue |
A | GLY28 |
A | ARG32 |
A | ARG93 |
A | GLY95 |
A | THR96 |
A | IMH280 |
B | ARG50 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 282 |
Chain | Residue |
A | ARG14 |
A | ARG16 |
A | ASP19 |
A | LEU46 |
A | HOH319 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 283 |
Chain | Residue |
A | PRO11 |
A | ARG14 |
A | ASN49 |
A | ARG50 |
A | HOH360 |
B | TYR221 |
B | ALA223 |
B | IMH280 |
B | HOH321 |
site_id | AC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE IMH B 280 |
Chain | Residue |
A | HIS12 |
A | GOL283 |
B | ILE71 |
B | ARG93 |
B | THR96 |
B | CYS97 |
B | GLY98 |
B | PHE165 |
B | ASP186 |
B | MET187 |
B | GLU188 |
B | ASP210 |
B | PRO213 |
B | TRP216 |
B | PO4281 |
B | HOH289 |
B | HOH305 |
B | HOH318 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 B 281 |
Chain | Residue |
A | ARG50 |
B | GLY28 |
B | ARG32 |
B | ARG93 |
B | GLY95 |
B | THR96 |
B | IMH280 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 282 |
Chain | Residue |
B | ARG14 |
B | ARG16 |
B | ASP19 |
B | LEU46 |
B | HOH297 |
site_id | AC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 283 |
Chain | Residue |
A | TYR221 |
A | ALA223 |
A | IMH280 |
A | HOH333 |
B | PRO11 |
B | ARG14 |
B | ASN49 |
B | ARG50 |
B | HOH322 |