3MB8
Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE IMH A 280 |
| Chain | Residue |
| A | ILE71 |
| A | PRO213 |
| A | TRP216 |
| A | PO4281 |
| A | HOH295 |
| A | HOH312 |
| A | HOH313 |
| B | HIS12 |
| B | GOL283 |
| A | ARG93 |
| A | THR96 |
| A | CYS97 |
| A | GLY98 |
| A | ASP186 |
| A | MET187 |
| A | GLU188 |
| A | ASP210 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 281 |
| Chain | Residue |
| A | GLY28 |
| A | ARG32 |
| A | ARG93 |
| A | GLY95 |
| A | THR96 |
| A | IMH280 |
| B | ARG50 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 282 |
| Chain | Residue |
| A | ARG14 |
| A | ARG16 |
| A | ASP19 |
| A | LEU46 |
| A | HOH319 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 283 |
| Chain | Residue |
| A | PRO11 |
| A | ARG14 |
| A | ASN49 |
| A | ARG50 |
| A | HOH360 |
| B | TYR221 |
| B | ALA223 |
| B | IMH280 |
| B | HOH321 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE IMH B 280 |
| Chain | Residue |
| A | HIS12 |
| A | GOL283 |
| B | ILE71 |
| B | ARG93 |
| B | THR96 |
| B | CYS97 |
| B | GLY98 |
| B | PHE165 |
| B | ASP186 |
| B | MET187 |
| B | GLU188 |
| B | ASP210 |
| B | PRO213 |
| B | TRP216 |
| B | PO4281 |
| B | HOH289 |
| B | HOH305 |
| B | HOH318 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 281 |
| Chain | Residue |
| A | ARG50 |
| B | GLY28 |
| B | ARG32 |
| B | ARG93 |
| B | GLY95 |
| B | THR96 |
| B | IMH280 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 282 |
| Chain | Residue |
| B | ARG14 |
| B | ARG16 |
| B | ASP19 |
| B | LEU46 |
| B | HOH297 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 283 |
| Chain | Residue |
| A | TYR221 |
| A | ALA223 |
| A | IMH280 |
| A | HOH333 |
| B | PRO11 |
| B | ARG14 |
| B | ASN49 |
| B | ARG50 |
| B | HOH322 |
