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7WP6
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BU of 7wp6 by Molmil
Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK in complex with three neutralizing antibodies
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 36H6 heavy chain, ...
Authors:Zheng, Q, Sun, H, Yuan, Q, Li, S, Xia, N.
Deposit date:2022-01-23
Release date:2023-03-01
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.
Cell Host Microbe, 30, 2022
7WP8
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BU of 7wp8 by Molmil
Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK1628x in complex with three neutralizing antibodies
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2B4 heavy chain, ...
Authors:Zheng, Q, Sun, H, Yuan, Q, Li, S, Xia, N.
Deposit date:2022-01-23
Release date:2023-03-08
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.
Cell Host Microbe, 30, 2022
8JBA
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BU of 8jba by Molmil
Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors
Descriptor: (2~{S})-2-[[3-[[5-[(2-methyl-3-phenyl-phenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]methylamino]-3-oxidanyl-propanoic acid, Programmed cell death 1 ligand 1
Authors:Cheng, Y, Xiao, Y.B.
Deposit date:2023-05-08
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents.
J.Med.Chem., 66, 2023
8J1I
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BU of 8j1i by Molmil
Crystal Structure of EphA8/SASH1 Complex
Descriptor: Ephrin type-A receptor 8, SAM and SH3 domain-containing protein 1
Authors:Liu, W, Li, J, Ding, Y.
Deposit date:2023-04-12
Release date:2024-02-28
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions.
J.Mol.Biol., 435, 2023
8XRY
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BU of 8xry by Molmil
Cryo-EM structure of OSCA3.1-1.1ver(Y367N-G454S-Y458I)-open/open state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-08
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XNG
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BU of 8xng by Molmil
Cryo-EM structure of OSCA1.2-liposome-inside-out closed state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2023-12-29
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XS4
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BU of 8xs4 by Molmil
Cryo-EM structure of OSCA1.2-DOPC-1:20-contracted1 state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-08
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XW1
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BU of 8xw1 by Molmil
Cryo-EM structure of OSCA1.2-V335W-DDM state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4.49 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XW2
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BU of 8xw2 by Molmil
Cryo-EM structure of OSCA1.2-DOPC-1:50-contracted state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XW3
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BU of 8xw3 by Molmil
Cryo-EM structure of OSCA1.2-DOPC-1:50-expanded state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XS5
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BU of 8xs5 by Molmil
Cryo-EM structure of OSCA1.2-DOPC-1:20-contracted2 state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-08
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XW0
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BU of 8xw0 by Molmil
Cryo-EM structure of OSCA3.1-GDN state
Descriptor: CSC1-like protein ERD4, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XVY
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BU of 8xvy by Molmil
Cryo-EM structure of OSCA3.1-2E(R611E-R619E)-closed/open state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XVZ
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BU of 8xvz by Molmil
Cryo-EM structure of OSCA3.1-2E(R611E-R619E)-closed/'desensitized' state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XW4
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BU of 8xw4 by Molmil
Cryo-EM structure of TMEM63B-Digitonin state
Descriptor: CSC1-like protein 2
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XS0
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BU of 8xs0 by Molmil
Cryo-EM structure of OSCA3.1-1.1ver(Y367N-G454S-Y458I)-open/'desensitized' state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-08
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XVX
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BU of 8xvx by Molmil
Cryo-EM structure of OSCA1.2-DOPC-1:20-expanded state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XAJ
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BU of 8xaj by Molmil
Cryo-EM structure of OSCA1.2-liposome-inside-in open state
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2023-12-04
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8Y13
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BU of 8y13 by Molmil
Cryo-EM structure of anti-phage defense associated DSR2 tetramer (H171A)
Descriptor: SIR2-like domain-containing protein
Authors:Li, F.X, Shi, Z.B, Wang, R.W, Xu, Q, Yang, R, Wu, Z.X.
Deposit date:2024-01-23
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
8Y3M
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BU of 8y3m by Molmil
Cryo-EM structure of DSR2-DSAD1 complex (cross-linked)
Descriptor: DSR anti-defence 1, SIR2-like domain-containing protein
Authors:Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X.
Deposit date:2024-01-29
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
8Y3W
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BU of 8y3w by Molmil
The Cryo-EM structure of anti-phage defense associated DSR2 tetramer bound with two DSAD1 inhibitors (same side)
Descriptor: DSR anti-defence 1, SIR2-like domain-containing protein
Authors:Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X.
Deposit date:2024-01-29
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
8ZC9
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BU of 8zc9 by Molmil
The Cryo-EM structure of DSR2-Tail tube-NAD+ complex
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein, tail tube protein
Authors:Wang, R, Xu, Q, Wu, Z, Li, J, Yang, R, Shi, Z, Li, F.
Deposit date:2024-04-29
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
8Y34
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BU of 8y34 by Molmil
Cryo-EM structure of anti-phage defense associated DSR2 (H171A) (map2)
Descriptor: SIR2-like domain-containing protein
Authors:Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X.
Deposit date:2024-01-28
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
8Y3Y
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BU of 8y3y by Molmil
The Cryo-EM structure of anti-phage defense associated DSR2 tetramer bound with two DSAD1 inhibitors (opposite side)
Descriptor: DSR anti-defence 1, SIR2-like domain-containing protein
Authors:Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X.
Deposit date:2024-01-29
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
5XHQ
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BU of 5xhq by Molmil
Apolipoprotein N-acyl Transferase
Descriptor: Apolipoprotein N-acyltransferase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Yingzhi, X, Yong, X, Guangyuan, L, Fei, S.
Deposit date:2017-04-23
Release date:2017-07-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.587 Å)
Cite:Crystal structure of E. coli apolipoprotein N-acyl transferase
Nat Commun, 8, 2017
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