3TAY
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5VKU
| An atomic structure of the human cytomegalovirus (HCMV) capsid with its securing layer of pp150 tegument protein | Descriptor: | Major capsid protein, Small capsomere-interacting protein, Tegument protein pp150, ... | Authors: | Yu, X, Jih, J, Jiang, J, Zhou, H. | Deposit date: | 2017-04-24 | Release date: | 2017-06-28 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150. Science, 356, 2017
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2QCT
| Structure of Lyp with inhibitor I-C11 | Descriptor: | 1,2-ETHANEDIOL, 6-HYDROXY-3-{(4R)-1-[4-(1-NAPHTHYLAMINO)-4-OXOBUTYL]-1,2,3-TRIAZOLIDIN-4-YL}-1-BENZOFURAN-5-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 22 | Authors: | Yu, X, Sun, J.P, Zhang, Z.Y. | Deposit date: | 2007-06-19 | Release date: | 2007-11-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of Lyp and its complex with a selective inhibitor To be Published
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8I0K
| Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase(E1) with TCAIM complex | Descriptor: | 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, 2-oxoglutarate dehydrogenase complex component E1, CALCIUM ION, ... | Authors: | Yu, X, Yang, W, Zhong, Y.H, Ma, X.M, Gao, Y.Z. | Deposit date: | 2023-01-11 | Release date: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase (E1) with TCAIM complex To Be Published
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3B8K
| Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2) | Descriptor: | Dihydrolipoyllysine-residue acetyltransferase | Authors: | Yu, X, Hiromasa, Y, Tsen, H, Stoops, J.K, Roche, T.E, Zhou, Z.H. | Deposit date: | 2007-11-01 | Release date: | 2008-01-22 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (8.8 Å) | Cite: | Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains Structure, 16, 2008
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2REC
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8SWK
| Cryo-EM structure of NLRP3 closed hexamer | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-18 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.32 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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8SXN
| Structure of NLRP3 and NEK7 complex | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-22 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.04 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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8SWF
| Cryo-EM structure of NLRP3 open octamer | Descriptor: | NACHT, LRR and PYD domains-containing protein 3 | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-18 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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3OMH
| Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide | Descriptor: | Src kinase-associated phosphoprotein 2, Tyrosine-protein phosphatase non-receptor type 22 | Authors: | Yu, X, Sun, J.-P, Zhang, S, Zhang, Z.-Y. | Deposit date: | 2010-08-26 | Release date: | 2011-06-29 | Last modified: | 2011-09-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate. J.Biol.Chem., 286, 2011
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4ZS6
| Receptor binding domain and Fab complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S protein, fab Heavy Chain, ... | Authors: | Yu, X, Wang, X. | Deposit date: | 2015-05-13 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.166 Å) | Cite: | Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 Sci Rep, 5, 2015
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3FCG
| Crystal Structure Analysis of the Middle Domain of the Caf1A Usher | Descriptor: | CHLORIDE ION, F1 capsule-anchoring protein | Authors: | Yu, X, Visweswaran, G.R, Duck, Z, Marupakula, S, MacIntyre, S, Knight, S, Zavialov, A.V. | Deposit date: | 2008-11-21 | Release date: | 2008-12-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion Biochem.J., 418, 2009
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3CNF
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3OLR
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8DPM
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6J7O
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q from Mycobacterium tuberculosis | Descriptor: | MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7T
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A from Mycobacterium tuberculosis | Descriptor: | GLYCEROL, MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2020-05-20 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7R
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A co-expressed with TakA from Mycobacterium tuberculosis | Descriptor: | MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7N
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A co-expressed with TakA from Mycobacterium tuberculosis | Descriptor: | MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.294 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7S
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis | Descriptor: | MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7P
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q co-expressed with TakA from Mycobacterium tuberculosis | Descriptor: | MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2020-05-20 | Method: | X-RAY DIFFRACTION (2.629 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7Q
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A from Mycobacterium tuberculosis | Descriptor: | CALCIUM ION, MAGNESIUM ION, guanylyltransferase-like toxin | Authors: | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | Deposit date: | 2019-01-18 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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4BM7
| Crystal Structure of IgG Fc F241A mutant with native glycosylation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, IG GAMMA-1 CHAIN C REGION | Authors: | Yu, X, Baruah, K, Harvey, D.J, Vasiljevic, S, Alonzi, D.S, Song, B, Higgins, M.K, Bowden, T.A, Crispin, M, Scanlan, C.N. | Deposit date: | 2013-05-07 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Engineering Hydrophobic Protein-Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies. J.Am.Chem.Soc., 135, 2013
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3IZX
| 3.1 Angstrom cryoEM structure of cytoplasmic polyhedrosis virus | Descriptor: | Capsid protein VP1, Structural protein VP3, Viral structural protein 5 | Authors: | Yu, X, Ge, P, Jiang, J, Atanasov, I, Zhou, Z.H. | Deposit date: | 2011-01-15 | Release date: | 2011-06-22 | Last modified: | 2018-08-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Atomic Model of CPV Reveals the Mechanism Used by This Single-Shelled Virus to Economically Carry Out Functions Conserved in Multishelled Reoviruses. Structure, 19, 2011
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8FU9
| Structure of Covid Spike variant deltaN25 with one erect RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Yu, X, Juraszek, J, Rutten, L, Bakkers, M.J.G, Blokland, S, Van den Broek, N.J.F, Verwilligen, A.Y.W, Abeywickrema, P, Vingerhoets, J, Neefs, J, Bakhash, S.A.M, Roychoudhury, P, Greninger, A, Sharma, S, Langedijk, J.P.M. | Deposit date: | 2023-01-16 | Release date: | 2023-04-05 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike. Plos Pathog., 19, 2023
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