8I0K

Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase(E1) with TCAIM complex

Summary for 8I0K

• Entry DOI: 10.2210/pdb8i0k/pdb
• EMDB information: 35042
• Descriptor: 2-oxoglutarate dehydrogenase complex component E1, T-cell activation inhibitor, mitochondrial, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: ogdh, proteostasis, dnajc, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 243961.03

Authors

Yu, X.,Yang, W.,Zhong, Y.H.,Ma, X.M.,Gao, Y.Z. (deposition date: 2023-01-11, release date: 2024-05-01, Last modification date: 2025-11-12)

• Primary citation: Wang, J.,Yu, X.,Zhong, Y.,Ma, X.,Gao, Y.,Zhou, D.,Wang, J.,Fu, Y.,Fan, S.,Su, J.,Huang, M.,Haigis, M.,Wang, P.,Xu, Y.,Yang, W.; The mitochondrial DNAJC co-chaperone TCAIM reduces alpha-ketoglutarate dehydrogenase protein levels to regulate metabolism; Mol.Cell, 85:638-, 2025; DOI: 10.1016/j.molcel.2025.01.006

Experimental method

ELECTRON MICROSCOPY (2.86 Å)