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5L73
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BU of 5l73 by Molmil
MAM domain of human neuropilin-1
分子名称: BICINE, CALCIUM ION, Neuropilin-1, ...
著者Yelland, T, Djordjevic, S.
登録日2016-06-01
公開日2016-10-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture.
Structure, 24, 2016
7OK6
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BU of 7ok6 by Molmil
Crystal structure of UNC119B in complex with LCK peptide
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, LCK peptide, ...
著者Yelland, T, Ismail, S.
登録日2021-05-17
公開日2021-06-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms.
Biochemistry, 60, 2021
7OK7
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BU of 7ok7 by Molmil
Crystal structure of the UNC119B ARL3 complex
分子名称: 1,2-ETHANEDIOL, ADP-ribosylation factor-like protein 3, GLYCEROL, ...
著者Yelland, T, Ismail, S.
登録日2021-05-17
公開日2021-06-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms.
Biochemistry, 60, 2021
7AJK
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BU of 7ajk by Molmil
Crystal structure of CRYI-B Rac1 complex
分子名称: CYFIP-related Rac1 interactor B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Yelland, T, Anh, L, Insall, R, Machesky, L, Ismail, S.
登録日2020-09-29
公開日2020-11-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Structure, 29, 2021
7AJL
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BU of 7ajl by Molmil
Cyrstal structure of CYRI-B/Fam49B
分子名称: CYFIP-related Rac1 interactor B
著者Yelland, T, Anh, H, Insall, R, Machesky, L, Ismail, S.
登録日2020-09-29
公開日2020-11-18
最終更新日2021-06-02
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Structure, 29, 2021
7Q9Q
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BU of 7q9q by Molmil
Crystal structure of PDE6D Geranylgeranylated cystein complex
分子名称: 1,2-ETHANEDIOL, GERAN-8-YL GERAN, O-METHYLCYSTEINE, ...
著者Yelland, T, Ismail, S.
登録日2021-11-14
公開日2022-01-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7Q9S
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BU of 7q9s by Molmil
Crystal structure of PDE6D KRas peptide complex with Compound-1
分子名称: 1,2-ETHANEDIOL, 2-methyl-3-(1~{H}-pyrazol-5-yl)imidazo[1,2-a]pyridine, DIMETHYL SULFOXIDE, ...
著者Yelland, T, Ismail, S.
登録日2021-11-14
公開日2022-01-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7Q9R
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BU of 7q9r by Molmil
Cocrystal structure of PDE6D bound to NRAS peptide
分子名称: 1,2-ETHANEDIOL, FARNESYL, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ...
著者Yelland, T, Ismail, S.
登録日2021-11-14
公開日2022-01-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7QF9
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BU of 7qf9 by Molmil
Crystal structure of PDE6D bound to HRas peptide
分子名称: 1,2-ETHANEDIOL, FARNESYL, HRas peptide, ...
著者Yelland, T, Ismail, I.
登録日2021-12-05
公開日2022-02-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7Q9U
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BU of 7q9u by Molmil
Crystal structure of the high affinity KRas mutant PDE6D complex
分子名称: 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ...
著者Yelland, T, Ismail, I.
登録日2021-11-14
公開日2022-01-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.238 Å)
主引用文献Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7QJK
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BU of 7qjk by Molmil
Crystal structure of PDE6D in complex with Compound-2
分子名称: 1,2-ETHANEDIOL, N-(phenylmethyl)pyridin-2-amine, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ...
著者Yelland, T, Ismail, S.
登録日2021-12-16
公開日2022-01-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
6FMF
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BU of 6fmf by Molmil
Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure
分子名称: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid
著者Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P.
登録日2018-01-31
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.811 Å)
主引用文献Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
6FMC
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BU of 6fmc by Molmil
Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure
分子名称: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1
著者Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P.
登録日2018-01-30
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
6H6A
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BU of 6h6a by Molmil
Crystal structure of UNC119 in complex with LCK peptide
分子名称: GLY-CYS-GLY-CYS-SER-SER, GLYCEROL, MYRISTIC ACID, ...
著者Yelland, T, ElMaghloob, Y, McIlwraith, M, Stephen, L, Ismail, S.
登録日2018-07-26
公開日2018-09-26
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Dev.Cell, 47, 2018
7ZC8
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BU of 7zc8 by Molmil
Crystal structure of the C-terminal domain of FusB, a TonB homologue
分子名称: Protein TonB
著者Wojnowska, M, Walker, D, Yelland, T.
登録日2022-03-25
公開日2022-08-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Crystal structure of the C-terminal domain of FusB, a TonB homologue
To Be Published
7P5U
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BU of 7p5u by Molmil
Neuropilin-b1 in a complex with a VEGFB-derived peptide
分子名称: MGC0122, Neuropilin-1
著者Fotinou, C, Rhana, R, Yelland, T.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Neuropilin-b1 in a complex with a VEGFB-derived peptide
To Be Published
6TDB
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BU of 6tdb by Molmil
Neuropilin2-b1 domain in a complex with the C-terminal VEGFB167 peptide
分子名称: 1,2-ETHANEDIOL, ACETYL GROUP, C-terminal VEGFB167 peptide, ...
著者Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S.
登録日2019-11-08
公開日2020-11-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献NRP2-b1 domain in a complex with the C-terminal VEGFB167 peptide
To Be Published
6TJT
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BU of 6tjt by Molmil
Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide
分子名称: 1,2-ETHANEDIOL, Neuropilin-2, SULFATE ION, ...
著者Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S.
登録日2019-11-26
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献NRP2-b1 domain in a complex with the C-terminal VEGFC peptide
To Be Published
6TKK
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BU of 6tkk by Molmil
Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
分子名称: 1,2-ETHANEDIOL, ACE-ARG-PRO-GLN-PRO-ARG, Neuropilin-1
著者Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S.
登録日2019-11-28
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.06 Å)
主引用文献Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
To Be Published
5IJR
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BU of 5ijr by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand.
分子名称: DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-03-02
公開日2017-03-29
最終更新日2018-07-11
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
5IYY
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BU of 5iyy by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-4 ligand.
分子名称: Neuropilin-1, N~2~-[(benzyloxy)carbonyl]-L-arginine
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-03-24
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
5JHK
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BU of 5jhk by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-6 ligand.
分子名称: N-(benzenecarbonyl)glycyl-L-arginine, Neuropilin-1
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-04-21
公開日2017-05-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
5J1X
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BU of 5j1x by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-5 ligand.
分子名称: DIMETHYL SULFOXIDE, Neuropilin-1, N~2~-(tert-butoxycarbonyl)-L-arginine
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-03-29
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
5JGQ
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BU of 5jgq by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-7 ligand.
分子名称: DIMETHYL SULFOXIDE, Neuropilin-1, N~2~-(benzenecarbonyl)-L-arginine
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-04-20
公開日2017-05-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
5JGI
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BU of 5jgi by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with M45 compound
分子名称: N-ALPHA-L-ACETYL-ARGININE, Neuropilin-1
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-04-20
公開日2017-05-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018

 

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