3R65
| MthK channel pore E92Q mutant | 分子名称: | Calcium-gated potassium channel mthK, POTASSIUM ION | 著者 | Shi, N, Zeng, W, Ye, S, Li, Y, Jiang, Y. | 登録日 | 2011-03-21 | 公開日 | 2012-02-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crucial points within the pore as determinants of K+ channel conductance and gating J.Mol.Biol., 411, 2011
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6KKU
| human KCC1 structure determined in NaCl and GDN | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | 登録日 | 2019-07-27 | 公開日 | 2019-10-23 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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6KKT
| human KCC1 structure determined in KCl and lipid nanodisc | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | 登録日 | 2019-07-27 | 公開日 | 2019-10-23 | 最終更新日 | 2020-08-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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6KKR
| human KCC1 structure determined in KCl and detergent GDN | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | 登録日 | 2019-07-27 | 公開日 | 2019-10-23 | 最終更新日 | 2020-08-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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4NJL
| Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core | 分子名称: | S protein, TRIETHYLENE GLYCOL | 著者 | Zhu, Y, Lu, L, Qin, L, Ye, S, Jiang, S, Zhang, R. | 登録日 | 2013-11-10 | 公開日 | 2014-02-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun, 5, 2014
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4PV7
| Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor | 分子名称: | 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine, Dipeptidyl peptidase 4 soluble form | 著者 | Xiao, P, Guo, R, Huang, S, Cui, H, Ye, S, Zhang, Z. | 登録日 | 2014-03-15 | 公開日 | 2015-03-18 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold Chin.Chem.Lett., 25, 2014
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6JGY
| Crystal structure of LASV-GP2 in a post fusion conformation | 分子名称: | Pre-glycoprotein polyprotein GP complex | 著者 | Zhu, Y, Zhang, X, Chen, B, Ye, S, Zhang, R. | 登録日 | 2019-02-15 | 公開日 | 2019-09-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.389 Å) | 主引用文献 | Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors. Front Microbiol, 10, 2019
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8I6V
| Cryo-EM structure of the polyphosphate polymerase VTC complex(Vtc4/Vtc3/Vtc1) | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Mayer, A, Wu, S, Ye, S. | 登録日 | 2023-01-29 | 公開日 | 2023-03-01 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Cryo-EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit. Embo J., 42, 2023
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7BP3
| Cryo-EM structure of the human MCT2 | 分子名称: | Monocarboxylate transporter 2 | 著者 | Zhang, B, Jin, Q, Zhang, X, Guo, J, Ye, S. | 登録日 | 2020-03-21 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun, 11, 2020
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4GVL
| Crystal Structure of the GsuK RCK domain | 分子名称: | ADENOSINE MONOPHOSPHATE, CALCIUM ION, TrkA domain protein, ... | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | 登録日 | 2012-08-30 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
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4KWE
| GDP-bound, double-stranded, curved FtsZ protofilament structure | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Li, Y, Hsin, J, Zhao, L, Cheng, Y, Shang, W, Huang, K.C, Wang, H.W, Ye, S. | 登録日 | 2013-05-23 | 公開日 | 2013-07-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation Science, 341, 2013
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4N5Q
| Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 | 分子名称: | Transient receptor potential cation channel subfamily V member 3 | 著者 | Shi, D.J, Ye, S, Cao, X, Wang, K.W, Zhang, R. | 登録日 | 2013-10-10 | 公開日 | 2014-01-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function Protein Cell, 4, 2013
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6A30
| Crystal Structure of Munc13-1 MUN Domain and Synaptobrevin-2 Juxtamembrane Linker Region | 分子名称: | Protein unc-13 homolog A, Synaptobrevin-2 juxtamembrane linker peptide | 著者 | Wang, S, Li, Y, Gong, J.H, Ye, S, Yang, X.F, Zhang, R.G, Ma, C. | 登録日 | 2018-06-14 | 公開日 | 2019-01-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.793 Å) | 主引用文献 | Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly. Nat Commun, 10, 2019
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6A96
| Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, ... | 著者 | Liu, S, Xu, L, Guan, F, Liu, Y.T, Cui, Y, Zhang, Q, Bi, G.Q, Zhou, Z.H, Zhang, X, Ye, S. | 登録日 | 2018-07-11 | 公開日 | 2018-10-03 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Cryo-EM structure of the human alpha 5 beta 3 GABAAreceptor. Cell Res., 28, 2018
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3NAF
| Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+ gated K+ Channel (BK Channel) | 分子名称: | Calcium-activated potassium channel subunit alpha-1,Calcium-activated potassium channel subunit alpha-1,Calcium-activated potassium channel subunit alpha-1 | 著者 | Wu, Y, Yang, Y, Ye, S, Jiang, Y. | 登録日 | 2010-06-01 | 公開日 | 2010-06-30 | 最終更新日 | 2017-06-21 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature, 466, 2010
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7YVC
| Aplysia californica FaNaC in apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Chen, Q.F, Liu, F.L, Dang, Y, Feng, H, Zhang, Z, Ye, S. | 登録日 | 2022-08-19 | 公開日 | 2023-08-09 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily. Nat.Chem.Biol., 19, 2023
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7YVB
| Aplysia californica FaNaC in ligand bound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide-gated Na+ channel, ... | 著者 | Chen, Q.F, Liu, F.L, Dang, Y, Feng, H, Zhang, Z, Ye, S. | 登録日 | 2022-08-19 | 公開日 | 2023-08-09 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily. Nat.Chem.Biol., 19, 2023
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6A0A
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6A0C
| Structure of a triple-helix region of human collagen type III | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, collagen type III peptide | 著者 | Yang, X, Zhu, Y, Ye, S, Zhang, R. | 登録日 | 2018-06-05 | 公開日 | 2018-12-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity. Biochem. Biophys. Res. Commun., 508, 2019
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6JEC
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6JKM
| Crystal structure of BubR1 kinase domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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6JKL
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6JKK
| Crystal structure of BubR1 kinase domain | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Mitotic checkpoint control protein kinase BUB1 | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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1J04
| Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro | 分子名称: | (AMINOOXY)ACETIC ACID, GLYCEROL, alanine--glyoxylate aminotransferase | 著者 | Zhang, X, Djordjevic, S, Bartlam, M, Ye, S, Rao, Z, Danpure, C.J. | 登録日 | 2002-10-30 | 公開日 | 2003-11-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting. Acta Crystallogr.,Sect.F, 66, 2010
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7D99
| human potassium-chloride co-transporter KCC4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Xie, Y, Chang, S, Zhao, C, Ye, S, Guo, J. | 登録日 | 2020-10-12 | 公開日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv, 6, 2020
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