Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
8UV0
DownloadVisualize
BU of 8uv0 by Molmil
Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
Authors:Deller, M.C, Epling, L.B.
Deposit date:2023-11-02
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J.Med.Chem., 67, 2024
2JM1
DownloadVisualize
BU of 2jm1 by Molmil
Structures and chemical shift assignments for the ADD domain of the ATRX protein
Descriptor: Transcriptional regulator ATRX, ZINC ION
Authors:Yang, J, Neuhaus, D.
Deposit date:2006-09-13
Release date:2007-06-26
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Proc.Natl.Acad.Sci.USA, 104, 2007
2K0A
DownloadVisualize
BU of 2k0a by Molmil
1H, 15N and 13C chemical shift assignments for Rds3 protein
Descriptor: Pre-mRNA-splicing factor RDS3, ZINC ION
Authors:Loening, N, van Roon, A, Yang, J, Nagai, K, Neuhaus, D.
Deposit date:2008-01-31
Release date:2008-07-22
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2JPS
DownloadVisualize
BU of 2jps by Molmil
NAB2 N-terminal domain
Descriptor: Nuclear polyadenylated RNA-binding protein NAB2
Authors:Grant, R, Marshall, N.J, Yang, J, Fasken, M, Kelly, S, Harreman, M.T, Neuhaus, D, Corbett, A.H, Stewart, M.
Deposit date:2007-05-23
Release date:2008-03-18
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2
J.Mol.Biol., 376, 2008
2KQC
DownloadVisualize
BU of 2kqc by Molmil
Second PBZ domain of human APLF protein
Descriptor: Aprataxin and PNK-like factor, ZINC ION
Authors:Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQB
DownloadVisualize
BU of 2kqb by Molmil
First PBZ domain of human APLF protein
Descriptor: Aprataxin and PNK-like factor, ZINC ION
Authors:Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQD
DownloadVisualize
BU of 2kqd by Molmil
First PBZ domain of human APLF protein in complex with ribofuranosyladenosine
Descriptor: ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ...
Authors:Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQE
DownloadVisualize
BU of 2kqe by Molmil
Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine
Descriptor: ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ...
Authors:Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2L30
DownloadVisualize
BU of 2l30 by Molmil
Human PARP-1 zinc finger 1
Descriptor: Poly [ADP-ribose] polymerase 1, ZINC ION
Authors:Neuhaus, D, Eustermann, S, Yang, J, Videler, H.
Deposit date:2010-08-30
Release date:2011-02-02
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.
J.Mol.Biol., 407, 2011
2L31
DownloadVisualize
BU of 2l31 by Molmil
Human PARP-1 zinc finger 2
Descriptor: Poly [ADP-ribose] polymerase 1, ZINC ION
Authors:Neuhaus, D, Eustermann, S, Yang, J, Videler, H.
Deposit date:2010-08-30
Release date:2011-02-02
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.
J.Mol.Biol., 407, 2011
2L5G
DownloadVisualize
BU of 2l5g by Molmil
Co-ordinates and 1H, 13C and 15N chemical shift assignments for the complex of GPS2 53-90 and SMRT 167-207
Descriptor: G protein pathway suppressor 2, Putative uncharacterized protein NCOR2
Authors:Oberoi, J, Yang, J, Neuhaus, D, Schwabe, J.W.R.
Deposit date:2010-11-01
Release date:2011-02-02
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Nat.Struct.Mol.Biol., 18, 2011
2LD1
DownloadVisualize
BU of 2ld1 by Molmil
Structures and chemical shift assignments for the ADD domain of the ATRX protein
Descriptor: Transcriptional regulator ATRX, ZINC ION
Authors:Neuhaus, D, Yang, J.
Deposit date:2011-05-13
Release date:2011-06-08
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Proc.Natl.Acad.Sci.USA, 104, 2007
2N8A
DownloadVisualize
BU of 2n8a by Molmil
1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in complex with a DNA single-strand break
Descriptor: DNA (45-MER), Poly [ADP-ribose] polymerase 1, ZINC ION
Authors:Neuhaus, D, Eustermann, S, Yang, J, Wu, W.
Deposit date:2015-10-08
Release date:2015-12-02
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Mol.Cell, 60, 2015
2MY1
DownloadVisualize
BU of 2my1 by Molmil
Solution structure of Bud31p
Descriptor: Pre-mRNA-splicing factor BUD31, ZINC ION
Authors:van Roon, A.M, Yang, J, Mathieu, D, Bermel, W, Nagai, K, Neuhaus, D.
Deposit date:2015-01-19
Release date:2015-03-11
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:(113) Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.
Angew.Chem.Int.Ed.Engl., 54, 2015
6TX3
DownloadVisualize
BU of 6tx3 by Molmil
HPF1 bound to catalytic fragment of PARP2
Descriptor: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Histone PARylation factor 1, Poly [ADP-ribose] polymerase 2,Poly [ADP-ribose] polymerase 2
Authors:Suskiewicz, M.J, Ahel, I.
Deposit date:2020-01-13
Release date:2020-02-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TX1
DownloadVisualize
BU of 6tx1 by Molmil
HPF1 from Nematostella vectensis
Descriptor: Predicted protein
Authors:Suskiewicz, M.J, Ahel, I.
Deposit date:2020-01-13
Release date:2020-02-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TVH
DownloadVisualize
BU of 6tvh by Molmil
Selenomethionine-substituted HPF1 from Nematostella vectensis
Descriptor: Predicted protein
Authors:Ariza, A.
Deposit date:2020-01-09
Release date:2020-02-19
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TX2
DownloadVisualize
BU of 6tx2 by Molmil
Human HPF1
Descriptor: Histone PARylation factor 1, SODIUM ION
Authors:Suskiewicz, M.J, Ahel, I.
Deposit date:2020-01-13
Release date:2020-02-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
5YI6
DownloadVisualize
BU of 5yi6 by Molmil
CRISPR associated protein Cas6
Descriptor: CRISPR-associated endoribonuclease Cas6 1, GLYCEROL, PHOSPHATE ION
Authors:Ko, T.P, Hsieh, T.J, Chen, Y.
Deposit date:2017-10-03
Release date:2018-09-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Expression, Purification, Crystallization, and X-ray Structural Analysis of CRISPR-Associated Protein Cas6 from Methanocaldococcus jannaschii
Crystals, 7, 2018
2LHN
DownloadVisualize
BU of 2lhn by Molmil
RNA-binding zinc finger protein
Descriptor: Nuclear polyadenylated RNA-binding protein NAB2, ZINC ION
Authors:Brockmann, C, Neuhaus, D, Stewart, M.
Deposit date:2011-08-12
Release date:2012-06-27
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export.
Structure, 20, 2012
1IGC
DownloadVisualize
BU of 1igc by Molmil
IGG1 FAB FRAGMENT (MOPC21) COMPLEX WITH DOMAIN III OF PROTEIN G FROM STREPTOCOCCUS
Descriptor: IGG1-KAPPA MOPC21 FAB (HEAVY CHAIN), IGG1-KAPPA MOPC21 FAB (LIGHT CHAIN), STREPTOCOCCAL PROTEIN G (DOMAIN III)
Authors:Derrick, J.P, Wigley, D.B.
Deposit date:1994-08-05
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab.
J.Mol.Biol., 243, 1994
1IGD
DownloadVisualize
BU of 1igd by Molmil
THE THIRD IGG-BINDING DOMAIN FROM STREPTOCOCCAL PROTEIN G: AN ANALYSIS BY X-RAY CRYSTALLOGRAPHY OF THE STRUCTURE ALONE AND IN A COMPLEX WITH FAB
Descriptor: PROTEIN G
Authors:Derrick, J.P, Wigley, D.B.
Deposit date:1994-08-05
Release date:1994-11-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab.
J.Mol.Biol., 243, 1994
<12

 

219869

數據於2024-05-15公開中

PDB statisticsPDBj update infoContact PDBjnumon