6TX3

HPF1 bound to catalytic fragment of PARP2

Summary for 6TX3

• Entry DOI: 10.2210/pdb6tx3/pdb
• Descriptor: Poly [ADP-ribose] polymerase 2,Poly [ADP-ribose] polymerase 2, Histone PARylation factor 1, 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide (3 entities in total)
• Functional Keywords: parp2, artd2, adp-ribosylation, serine adp-ribosylation, hpf1, c4orf27, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 68966.48

Authors

Suskiewicz, M.J.,Ahel, I. (deposition date: 2020-01-13, release date: 2020-02-19, Last modification date: 2024-05-01)

• Primary citation: Suskiewicz, M.J.,Zobel, F.,Ogden, T.E.H.,Fontana, P.,Ariza, A.,Yang, J.C.,Zhu, K.,Bracken, L.,Hawthorne, W.J.,Ahel, D.,Neuhaus, D.,Ahel, I.; HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.; Nature, 579:598-602, 2020; PubMed: 32028527; DOI: 10.1038/s41586-020-2013-6

Experimental method

X-RAY DIFFRACTION (2.96 Å)