6TX3

HPF1 bound to catalytic fragment of PARP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Poly [ADP-ribose] polymerase 2,Poly [ADP-ribose] polymerase 2	polymer	280	31675.9	1	UniProt (Q9UGN5) Pfam (PF02877) Pfam (PF00644) In PDB	Homo sapiens (Human)	hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,DNA ADP-ribosyltransferase PARP2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2,Protein poly-ADP-ribosyltransferase PARP2,hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,DNA ADP-ribosyltransferase PARP2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2,Protein poly-ADP-ribosyltransferase PARP2
2	A	Histone PARylation factor 1	polymer	318	36753.0	1	UniProt (Q9NWY4) Pfam (PF10228) In PDB	Homo sapiens (Human)
3	B	2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide	non-polymer		537.5	1	Chemie (UHB)

Sequence modifications

B: 217 - 334 (UniProt: Q9UGN5)

PDB	External Database	Details
Met 197	-	initiating methionine
Gly 198	-	expression tag
Ser 199	-	expression tag
Ser 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
Ser 207	-	expression tag
Ser 208	-	expression tag
Gly 209	-	expression tag
Leu 210	-	expression tag
Val 211	-	expression tag
Pro 212	-	expression tag
Arg 213	-	expression tag
Gly 214	-	expression tag
Ser 215	-	expression tag
His 216	-	expression tag

B: 335 - 570 (UniProt: Q9UGN5)
A: 37 - 346 (UniProt: Q9NWY4)

PDB	External Database	Details
Met 29	-	initiating methionine
Gly 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
Lys 174	Arg 174	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68428.9
Non-Polymers*	Number of molecules	1
	Total formula weight	537.5
All*	Total formula weight	68966.5

*Water molecules are not included.