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8UV0
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BU of 8uv0 by Molmil
Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
分子名称: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
著者Deller, M.C, Epling, L.B.
登録日2023-11-02
公開日2024-02-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J.Med.Chem., 67, 2024
2JM1
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BU of 2jm1 by Molmil
Structures and chemical shift assignments for the ADD domain of the ATRX protein
分子名称: Transcriptional regulator ATRX, ZINC ION
著者Yang, J, Neuhaus, D.
登録日2006-09-13
公開日2007-06-26
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Proc.Natl.Acad.Sci.USA, 104, 2007
2K0A
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BU of 2k0a by Molmil
1H, 15N and 13C chemical shift assignments for Rds3 protein
分子名称: Pre-mRNA-splicing factor RDS3, ZINC ION
著者Loening, N, van Roon, A, Yang, J, Nagai, K, Neuhaus, D.
登録日2008-01-31
公開日2008-07-22
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2JPS
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BU of 2jps by Molmil
NAB2 N-terminal domain
分子名称: Nuclear polyadenylated RNA-binding protein NAB2
著者Grant, R, Marshall, N.J, Yang, J, Fasken, M, Kelly, S, Harreman, M.T, Neuhaus, D, Corbett, A.H, Stewart, M.
登録日2007-05-23
公開日2008-03-18
最終更新日2023-12-20
実験手法SOLUTION NMR
主引用文献Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2
J.Mol.Biol., 376, 2008
2KQC
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BU of 2kqc by Molmil
Second PBZ domain of human APLF protein
分子名称: Aprataxin and PNK-like factor, ZINC ION
著者Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
登録日2009-11-04
公開日2010-01-19
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQB
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BU of 2kqb by Molmil
First PBZ domain of human APLF protein
分子名称: Aprataxin and PNK-like factor, ZINC ION
著者Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
登録日2009-11-04
公開日2010-01-19
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQD
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BU of 2kqd by Molmil
First PBZ domain of human APLF protein in complex with ribofuranosyladenosine
分子名称: ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ...
著者Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
登録日2009-11-04
公開日2010-01-19
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQE
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BU of 2kqe by Molmil
Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine
分子名称: ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ...
著者Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J.
登録日2009-11-04
公開日2010-01-19
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2L30
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BU of 2l30 by Molmil
Human PARP-1 zinc finger 1
分子名称: Poly [ADP-ribose] polymerase 1, ZINC ION
著者Neuhaus, D, Eustermann, S, Yang, J, Videler, H.
登録日2010-08-30
公開日2011-02-02
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.
J.Mol.Biol., 407, 2011
2L31
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BU of 2l31 by Molmil
Human PARP-1 zinc finger 2
分子名称: Poly [ADP-ribose] polymerase 1, ZINC ION
著者Neuhaus, D, Eustermann, S, Yang, J, Videler, H.
登録日2010-08-30
公開日2011-02-02
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.
J.Mol.Biol., 407, 2011
2L5G
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BU of 2l5g by Molmil
Co-ordinates and 1H, 13C and 15N chemical shift assignments for the complex of GPS2 53-90 and SMRT 167-207
分子名称: G protein pathway suppressor 2, Putative uncharacterized protein NCOR2
著者Oberoi, J, Yang, J, Neuhaus, D, Schwabe, J.W.R.
登録日2010-11-01
公開日2011-02-02
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Nat.Struct.Mol.Biol., 18, 2011
2LD1
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BU of 2ld1 by Molmil
Structures and chemical shift assignments for the ADD domain of the ATRX protein
分子名称: Transcriptional regulator ATRX, ZINC ION
著者Neuhaus, D, Yang, J.
登録日2011-05-13
公開日2011-06-08
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Proc.Natl.Acad.Sci.USA, 104, 2007
2N8A
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BU of 2n8a by Molmil
1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in complex with a DNA single-strand break
分子名称: DNA (45-MER), Poly [ADP-ribose] polymerase 1, ZINC ION
著者Neuhaus, D, Eustermann, S, Yang, J, Wu, W.
登録日2015-10-08
公開日2015-12-02
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Mol.Cell, 60, 2015
2MY1
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BU of 2my1 by Molmil
Solution structure of Bud31p
分子名称: Pre-mRNA-splicing factor BUD31, ZINC ION
著者van Roon, A.M, Yang, J, Mathieu, D, Bermel, W, Nagai, K, Neuhaus, D.
登録日2015-01-19
公開日2015-03-11
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献(113) Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.
Angew.Chem.Int.Ed.Engl., 54, 2015
6TX3
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BU of 6tx3 by Molmil
HPF1 bound to catalytic fragment of PARP2
分子名称: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Histone PARylation factor 1, Poly [ADP-ribose] polymerase 2,Poly [ADP-ribose] polymerase 2
著者Suskiewicz, M.J, Ahel, I.
登録日2020-01-13
公開日2020-02-19
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TX1
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BU of 6tx1 by Molmil
HPF1 from Nematostella vectensis
分子名称: Predicted protein
著者Suskiewicz, M.J, Ahel, I.
登録日2020-01-13
公開日2020-02-19
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.091 Å)
主引用文献HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TVH
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BU of 6tvh by Molmil
Selenomethionine-substituted HPF1 from Nematostella vectensis
分子名称: Predicted protein
著者Ariza, A.
登録日2020-01-09
公開日2020-02-19
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (2.651 Å)
主引用文献HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TX2
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BU of 6tx2 by Molmil
Human HPF1
分子名称: Histone PARylation factor 1, SODIUM ION
著者Suskiewicz, M.J, Ahel, I.
登録日2020-01-13
公開日2020-02-19
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
5YI6
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BU of 5yi6 by Molmil
CRISPR associated protein Cas6
分子名称: CRISPR-associated endoribonuclease Cas6 1, GLYCEROL, PHOSPHATE ION
著者Ko, T.P, Hsieh, T.J, Chen, Y.
登録日2017-10-03
公開日2018-09-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Expression, Purification, Crystallization, and X-ray Structural Analysis of CRISPR-Associated Protein Cas6 from Methanocaldococcus jannaschii
Crystals, 7, 2018
2LHN
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BU of 2lhn by Molmil
RNA-binding zinc finger protein
分子名称: Nuclear polyadenylated RNA-binding protein NAB2, ZINC ION
著者Brockmann, C, Neuhaus, D, Stewart, M.
登録日2011-08-12
公開日2012-06-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export.
Structure, 20, 2012
1IGC
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BU of 1igc by Molmil
IGG1 FAB FRAGMENT (MOPC21) COMPLEX WITH DOMAIN III OF PROTEIN G FROM STREPTOCOCCUS
分子名称: IGG1-KAPPA MOPC21 FAB (HEAVY CHAIN), IGG1-KAPPA MOPC21 FAB (LIGHT CHAIN), STREPTOCOCCAL PROTEIN G (DOMAIN III)
著者Derrick, J.P, Wigley, D.B.
登録日1994-08-05
公開日1995-06-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab.
J.Mol.Biol., 243, 1994
1IGD
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BU of 1igd by Molmil
THE THIRD IGG-BINDING DOMAIN FROM STREPTOCOCCAL PROTEIN G: AN ANALYSIS BY X-RAY CRYSTALLOGRAPHY OF THE STRUCTURE ALONE AND IN A COMPLEX WITH FAB
分子名称: PROTEIN G
著者Derrick, J.P, Wigley, D.B.
登録日1994-08-05
公開日1994-11-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab.
J.Mol.Biol., 243, 1994
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