8JOU
| Fiber I and fiber-tail-adaptor of phage GP4 | Descriptor: | Virion-associated phage protein, rope protein of phage GP4 | Authors: | Liu, H, Chen, W. | Deposit date: | 2023-06-08 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers. J.Mol.Biol., 435, 2023
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8JOV
| Portal-tail complex of phage GP4 | Descriptor: | Portal protein, Putative tail fiber protein, Virion associated protein, ... | Authors: | Liu, H, Chen, W. | Deposit date: | 2023-06-08 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers. J.Mol.Biol., 435, 2023
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8JUL
| Cryo-EM structure of SIDT1 in complex with phosphatidic acid | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, SID1 transmembrane family member 1, ZINC ION | Authors: | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | Deposit date: | 2023-06-26 | Release date: | 2023-11-15 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Human SIDT1 mediates dsRNA uptake via its phospholipase activity. Cell Res., 34, 2024
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8JUN
| Cryo-EM structure of SIDT1 E555Q mutant | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SID1 transmembrane family member 1, ZINC ION | Authors: | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | Deposit date: | 2023-06-26 | Release date: | 2023-11-15 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (2.38 Å) | Cite: | Human SIDT1 mediates dsRNA uptake via its phospholipase activity. Cell Res., 34, 2024
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8KEE
| Cyanophage A-1(L) sheath-tube | Descriptor: | sheath, tube | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KEA
| Cyanophage A-1(L) baseplate-initiators | Descriptor: | baseplate gp16, central spike, hub, ... | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KEC
| Cyanophage A-1(L) tail fiber | Descriptor: | Long tail fiber, short tail fiber | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KE9
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8K66
| Cryo-EM structure of Oryza sativa HKT2;1 at 2.5 angstrom | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H. | Deposit date: | 2023-07-25 | Release date: | 2024-04-03 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters. Nat.Plants, 10, 2024
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8K69
| Cryo-EM structure of Oryza sativa HKT2;2/1 at 2.3 angstrom | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H. | Deposit date: | 2023-07-25 | Release date: | 2024-04-03 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.33 Å) | Cite: | Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters. Nat.Plants, 10, 2024
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8KEG
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8KEF
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7VDD
| Human TOM complex with cross-linking | Descriptor: | Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, Mitochondrial import receptor subunit TOM5 homolog, ... | Authors: | Liu, D.S, Sui, S.F. | Deposit date: | 2021-09-06 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VD2
| Human TOM complex without cross-linking | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, ... | Authors: | Liu, D.S, Sui, S.F. | Deposit date: | 2021-09-06 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VJT
| Crystal Structure of Mtb Pks13-TE in complex with inhibitor coumestan derivative 8 | Descriptor: | 3,8-bis(oxidanyl)-7-(piperidin-1-ylmethyl)-[1]benzofuro[3,2-c]chromen-6-one, Polyketide synthase Pks13 (Termination polyketide synthase) | Authors: | Zhang, W, Wang, S.S, Yu, L.F. | Deposit date: | 2021-09-28 | Release date: | 2022-09-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment. J.Med.Chem., 65, 2022
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7WCW
| Crystal structure of FGFR4(V550L) kinase domain with 7v | Descriptor: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | Authors: | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | Deposit date: | 2021-12-20 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.317 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65, 2022
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7WCT
| Crystal structure of FGFR4 kinase domain with 7v | Descriptor: | Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ... | Authors: | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | Deposit date: | 2021-12-20 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.106 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65, 2022
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7WCX
| Crystal structure of FGFR4(V550M) kinase domain with 7v | Descriptor: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | Authors: | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | Deposit date: | 2021-12-20 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.175 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65, 2022
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7YQK
| cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1 | Descriptor: | DNA (145-MER), Histone H2AX, Histone H2B, ... | Authors: | Ai, H.S, GuoChao, C, Qingyue, G, Ze-Bin, T, Zhiheng, D, Xin, L, Fan, Y, Ziyu, X, Jia-Bin, L, Changlin, T, Liu, L. | Deposit date: | 2022-08-07 | Release date: | 2022-08-17 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes. J.Am.Chem.Soc., 144, 2022
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7YPX
| Cyanophage Pam3 fiber | Descriptor: | Pam3 tail fiber proreins, tail fiber chaperone | Authors: | Wei, Z.L, Jiang, Y.L, Zhou, C.Z. | Deposit date: | 2022-08-04 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3. Viruses, 14, 2022
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7Y4T
| Crystal structure of cMET kinase domain bound by compound 9I | Descriptor: | 2-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-(3-nitrophenyl)pyridazin-3-one, Hepatocyte growth factor receptor | Authors: | Qu, L.Z, Chen, Y.H. | Deposit date: | 2022-06-16 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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7Y4U
| Crystal structure of cMET kinase domain bound by compound 9Y | Descriptor: | Hepatocyte growth factor receptor, ~{N}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide | Authors: | Qu, L.Z, Chen, Y.H. | Deposit date: | 2022-06-16 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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7YTT
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7YTU
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7DFB
| Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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