8JOU
 
 | | Fiber I and fiber-tail-adaptor of phage GP4 | | 分子名称: | Virion-associated phage protein, rope protein of phage GP4 | | 著者 | Liu, H, Chen, W. | | 登録日 | 2023-06-08 | | 公開日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers.
J.Mol.Biol., 435, 2023
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8JOV
 | | Portal-tail complex of phage GP4 | | 分子名称: | Portal protein, Putative tail fiber protein, Virion associated protein, ... | | 著者 | Liu, H, Chen, W. | | 登録日 | 2023-06-08 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers.
J.Mol.Biol., 435, 2023
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8JUL
 | | Cryo-EM structure of SIDT1 in complex with phosphatidic acid | | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, SID1 transmembrane family member 1, ZINC ION | | 著者 | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8JUN
 | | Cryo-EM structure of SIDT1 E555Q mutant | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SID1 transmembrane family member 1, ZINC ION | | 著者 | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | | 主引用文献 | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8KEE
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8KEA
 | | Cyanophage A-1(L) baseplate-initiators | | 分子名称: | baseplate gp16, central spike, hub, ... | | 著者 | Yu, R.C, Li, Q, Zhou, C.Z. | | 登録日 | 2023-08-11 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structure of the intact tail machine of Anabaena myophage A-1(L).
Nat Commun, 15, 2024
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8KEC
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8KE9
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8K66
 | | Cryo-EM structure of Oryza sativa HKT2;1 at 2.5 angstrom | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H. | | 登録日 | 2023-07-25 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.
Nat.Plants, 10, 2024
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8K69
 | | Cryo-EM structure of Oryza sativa HKT2;2/1 at 2.3 angstrom | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Wang, X, Shen, X, Qu, Y, Wang, C, Shen, H. | | 登録日 | 2023-07-25 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | | 主引用文献 | Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.
Nat.Plants, 10, 2024
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8KEG
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8KEF
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7VDD
 | | Human TOM complex with cross-linking | | 分子名称: | Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, Mitochondrial import receptor subunit TOM5 homolog, ... | | 著者 | Liu, D.S, Sui, S.F. | | 登録日 | 2021-09-06 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VD2
 | | Human TOM complex without cross-linking | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, ... | | 著者 | Liu, D.S, Sui, S.F. | | 登録日 | 2021-09-06 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VJT
 | | Crystal Structure of Mtb Pks13-TE in complex with inhibitor coumestan derivative 8 | | 分子名称: | 3,8-bis(oxidanyl)-7-(piperidin-1-ylmethyl)-[1]benzofuro[3,2-c]chromen-6-one, Polyketide synthase Pks13 (Termination polyketide synthase) | | 著者 | Zhang, W, Wang, S.S, Yu, L.F. | | 登録日 | 2021-09-28 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment.
J.Med.Chem., 65, 2022
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7WCW
 | | Crystal structure of FGFR4(V550L) kinase domain with 7v | | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.317 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
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7WCT
 | | Crystal structure of FGFR4 kinase domain with 7v | | 分子名称: | Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ... | | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.106 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
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7WCX
 | | Crystal structure of FGFR4(V550M) kinase domain with 7v | | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
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7YQK
 | | cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1 | | 分子名称: | DNA (145-MER), Histone H2AX, Histone H2B, ... | | 著者 | Ai, H.S, GuoChao, C, Qingyue, G, Ze-Bin, T, Zhiheng, D, Xin, L, Fan, Y, Ziyu, X, Jia-Bin, L, Changlin, T, Liu, L. | | 登録日 | 2022-08-07 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes.
J.Am.Chem.Soc., 144, 2022
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7YPX
 | | Cyanophage Pam3 fiber | | 分子名称: | Pam3 tail fiber proreins, tail fiber chaperone | | 著者 | Wei, Z.L, Jiang, Y.L, Zhou, C.Z. | | 登録日 | 2022-08-04 | | 公開日 | 2022-11-09 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3.
Viruses, 14, 2022
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7Y4T
 | | Crystal structure of cMET kinase domain bound by compound 9I | | 分子名称: | 2-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-(3-nitrophenyl)pyridazin-3-one, Hepatocyte growth factor receptor | | 著者 | Qu, L.Z, Chen, Y.H. | | 登録日 | 2022-06-16 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
J.Med.Chem., 65, 2022
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7Y4U
 | | Crystal structure of cMET kinase domain bound by compound 9Y | | 分子名称: | Hepatocyte growth factor receptor, ~{N}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide | | 著者 | Qu, L.Z, Chen, Y.H. | | 登録日 | 2022-06-16 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
J.Med.Chem., 65, 2022
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7YTT
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7YTU
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7DFB
 | | Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex | | 分子名称: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | | 著者 | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | | 登録日 | 2020-11-06 | | 公開日 | 2021-07-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.28 Å) | | 主引用文献 | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
Nat Commun, 12, 2021
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