1IYS
| Crystal Structure of Class A beta-Lactamase Toho-1 | Descriptor: | BETA-LACTAMASE TOHO-1, SULFATE ION | Authors: | Ibuka, A.S, Ishii, Y, Yamaguchi, K, Matsuzawa, H, Sakai, H. | Deposit date: | 2002-09-06 | Release date: | 2003-10-14 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structure of Extended-Spectrum beta-Lactamase Toho-1: Insights into the Molecular Mechanism for
Catalytic Reaction and Substrate Specificity Expansion Biochemistry, 42, 2003
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1WS7
| Crystal Structure of Mavicyanin from Cucurbita pepo medullosa (Zucchini) | Descriptor: | COPPER (I) ION, Mavicyanin | Authors: | Xie, Y, Inoue, T, Miyamoto, Y, Matsumura, H, Kataoka, K, Yamaguchi, K, Nojini, M, Suzuki, S, Kai, Y. | Deposit date: | 2004-11-02 | Release date: | 2004-11-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural reorganization of the copper binding site involving Thr15 of mavicyanin from Cucurbita pepo medullosa (zucchini) upon reduction. J.Biochem.(Tokyo), 137, 2005
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2D0W
| Crystal structure of cytochrome cL from Hyphomicrobium denitrificans | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, cytochrome cL | Authors: | Nojiri, M, Hira, D, Yamaguchi, K, Suzuki, S. | Deposit date: | 2005-08-10 | Release date: | 2006-08-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal structures of cytochrome c(L) and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins Biochemistry, 45, 2006
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2D0V
| Crystal structure of methanol dehydrogenase from Hyphomicrobium denitrificans | Descriptor: | CALCIUM ION, PYRROLOQUINOLINE QUINONE, methanol dehydrogenase large subunit, ... | Authors: | Nojiri, M, Hira, D, Yamaguchi, K, Suzuki, S. | Deposit date: | 2005-08-09 | Release date: | 2006-08-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Crystal structures of cytochrome c(L) and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins Biochemistry, 45, 2006
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7FB7
| Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, DIMETHYL SULFOXIDE, ... | Authors: | Kori, S, Arita, K, Yoshimi, S. | Deposit date: | 2021-07-08 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorg.Med.Chem., 52, 2021
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1AQ7
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1CUO
| CRYSTAL STRUCTURE ANALYSIS OF ISOMER-2 AZURIN FROM METHYLOMONAS J | Descriptor: | COPPER (II) ION, PROTEIN (AZURIN ISO-2) | Authors: | Inoue, T, Nishio, N, Kai, Y, Suzuki, S, Kataoka, K. | Deposit date: | 1999-08-21 | Release date: | 2000-08-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The significance of the flexible loop in the azurin (Az-iso2) from the obligate methylotroph Methylomonas sp. strain J. J.Mol.Biol., 333, 2003
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8GUZ
| Crystal structure of anti-FIXa IgG fab with FAST-Ig mutations | Descriptor: | 1,2-ETHANEDIOL, Anti-factor IXa IgG fab heavy chain, Anti-factor IXa IgG fab light chain | Authors: | Koga, H, Yamano, T, Fukami, T.A, Sampei, Z, Shiraiwa, H, Torizawa, T. | Deposit date: | 2022-09-14 | Release date: | 2023-06-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15, 2023
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8GV1
| Crystal structure of anti-FX IgG fab with FAST-Ig mutations | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Anti-factor X IgG fab heavy chain, ... | Authors: | Koga, H, Yamano, T, Fukami, T.A, Sampei, Z, Shiraiwa, H, Torizawa, T. | Deposit date: | 2022-09-14 | Release date: | 2023-06-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.186 Å) | Cite: | Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15, 2023
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8GV0
| Crystal structure of anti-FIXa IgG fab without FAST-Ig mutations | Descriptor: | Anti-factor IXa IgG fab heavy chain, Anti-factor IXa IgG fab light chain | Authors: | Koga, H, Yamano, T, Fukami, T.A, Sampei, Z, Shiraiwa, H, Torizawa, T. | Deposit date: | 2022-09-14 | Release date: | 2023-06-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.192 Å) | Cite: | Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15, 2023
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8GV2
| Crystal structure of anti-FX IgG fab without FAST-Ig mutations | Descriptor: | 1,2-ETHANEDIOL, Anti-factor X IgG fab heavy chain, Anti-factor X IgG fab light chain | Authors: | Koga, H, Yamano, T, Fukami, T.A, Sampei, Z, Shiraiwa, H, Torizawa, T. | Deposit date: | 2022-09-14 | Release date: | 2023-06-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.274 Å) | Cite: | Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15, 2023
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3LQ8
| Structure of the kinase domain of c-Met bound to XL880 (GSK1363089) | Descriptor: | Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Authors: | Lougheed, J.C, Stout, T.J. | Deposit date: | 2010-02-08 | Release date: | 2010-05-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res., 69, 2009
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7XI9
| Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form) | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... | Authors: | Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Structural basis for activation of DNMT1. Nat Commun, 13, 2022
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7XIB
| Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form) | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... | Authors: | Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (2.23 Å) | Cite: | Structural basis for activation of DNMT1. Nat Commun, 13, 2022
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4TOR
| Crystal structure of Tankyrase 1 with IWR-8 | Descriptor: | 1-[(1-acetyl-5-bromo-1H-indol-6-yl)sulfonyl]-N-ethyl-N-(3-methylphenyl)piperidine-4-carboxamide, CHLORIDE ION, Tankyrase-1, ... | Authors: | Chen, H, Zhang, X, Lum, L, Chen, C. | Deposit date: | 2014-06-06 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol.Cell.Biol., 35, 2015
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4TOS
| Crystal structure of Tankyrase 1 with 355 | Descriptor: | Tankyrase-1, ZINC ION, trans-N-benzyl-4-({1-[(6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}methyl)cyclohexanecarboxamide | Authors: | Chen, H, Zhang, X, Lum, l, Chen, C. | Deposit date: | 2014-06-06 | Release date: | 2015-05-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol.Cell.Biol., 35, 2015
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1A2C
| Structure of thrombin inhibited by AERUGINOSIN298-A from a BLUE-GREEN ALGA | Descriptor: | Aeruginosin 298-A, Hirudin variant-2, SODIUM ION, ... | Authors: | Rios-Steiner, J.L, Murakami, M, Tulinsky, A. | Deposit date: | 1997-12-26 | Release date: | 1998-07-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of Thrombin Inhibited by Aeruginosin 298-A from a Blue-Green Alga J.Am.Chem.Soc., 120, 1998
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8HYL
| Crystal structure of DO1 Fv-clasp fragment | Descriptor: | VH-SARAH, VL-SARAH | Authors: | Anan, Y, Lu, P, Nagata, K, Itakura, M, Uchida, K. | Deposit date: | 2023-01-06 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins Commun Biol, 7, 2024
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8IR6
| XFEL structure of cyanobacterial photosystem II following one flash (1F) with a 20-nanosecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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8IRI
| XFEL structure of cyanobacterial photosystem II following two flashes (2F) with a 5-millisecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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8IRD
| XFEL structure of cyanobacterial photosystem II following two flashes (2F) with a 20-nanosecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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8IRG
| XFEL structure of cyanobacterial photosystem II following two flashes (2F) with a 30-microsecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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8IRH
| XFEL structure of cyanobacterial photosystem II following two flashes (2F) with a 200-microsecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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8IR7
| XFEL structure of cyanobacterial photosystem II following one flash (1F) with a 200-nanosecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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8IRA
| XFEL structure of cyanobacterial photosystem II following one flash (1F) with a 200-microsecond delay | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Li, H, Suga, M, Shen, J.R. | Deposit date: | 2023-03-17 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Oxygen-evolving photosystem II structures during S 1 -S 2 -S 3 transitions. Nature, 626, 2024
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