7XUQ
| Crystal structure of Tpe3.0 complexed with N-Boc-3-alkenylindole | Descriptor: | Transcriptional regulator, PadR-like family, dimethyl 2-[[2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]methyl]-2-prop-2-enyl-propanedioate | Authors: | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | Deposit date: | 2022-05-19 | Release date: | 2022-09-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Enantioselective [2+2]-cycloadditions with triplet photoenzymes Nature, 611, 2022
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5V3S
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6M1V
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7SLR
| HIV Reverse Transcriptase with compound Pyr01 | Descriptor: | 5-(difluoromethyl)-3-({1-[(5-fluoro-2-oxo-1,2-dihydropyridin-3-yl)methyl]-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-1,6-dihydropyrimidin-5-yl}oxy)-2-methylbenzonitrile, Reverse transcriptase/ribonuclease H | Authors: | Klein, D.J, Zebisch, M, Gu, M. | Deposit date: | 2021-10-24 | Release date: | 2022-11-23 | Last modified: | 2023-03-29 | Method: | X-RAY DIFFRACTION (2.179 Å) | Cite: | Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med, 15, 2023
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7SLS
| HIV Reverse Transcriptase with compound Pyr02 | Descriptor: | 5-(difluoromethyl)-3-{[1-{[(3S)-5-fluoro-2-methyl-6-oxo-3,6-dihydropyridin-3-yl]methyl}-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-1,6-dihydropyrimidin-5-yl]oxy}-2-methylbenzonitrile, Reverse transcriptase/ribonuclease H | Authors: | Klein, D.J, Zebisch, M, Gu, M. | Deposit date: | 2021-10-24 | Release date: | 2022-11-23 | Last modified: | 2023-03-29 | Method: | X-RAY DIFFRACTION (2.078 Å) | Cite: | Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med, 15, 2023
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7TAI
| Structure of STEAP2 in complex with ligands | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Wang, L, Chen, K.H, Zhou, M. | Deposit date: | 2021-12-20 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2. Elife, 12, 2023
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6J8F
| Crystal structure of SVBP-VASH1 with peptide mimic the C-terminal of alpha-tubulin | Descriptor: | 8-mer peptide, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liao, S, Gao, J, Xu, C, Structural Genomics Consortium (SGC) | Deposit date: | 2019-01-18 | Release date: | 2019-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.283 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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6J8N
| Crystal structure of SVBP-VASH1 complex, mutation C169A of VASH1 | Descriptor: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liao, S, Gao, J, Xu, C, Structural Genomics Consortium (SGC) | Deposit date: | 2019-01-20 | Release date: | 2019-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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6J9H
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5TP9
| Structure of the human GluN1/GluN2A LBD in complex with compound 2 (GNE9178) | Descriptor: | 7-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, ACETATE ION, CALCIUM ION, ... | Authors: | Wallweber, H.J.A, Lupardus, P.J. | Deposit date: | 2016-10-20 | Release date: | 2016-11-30 | Last modified: | 2017-02-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett, 8, 2017
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6J91
| Structure of a hypothetical protease | Descriptor: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liao, S, Gao, J, Xu, C. | Deposit date: | 2019-01-21 | Release date: | 2019-06-19 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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5TPA
| Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500) | Descriptor: | (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile, GLUTAMIC ACID, GLYCINE, ... | Authors: | Wallweber, H.J.A, Lupardus, P.J. | Deposit date: | 2016-10-20 | Release date: | 2016-11-30 | Last modified: | 2017-02-01 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett, 8, 2017
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3P9U
| Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TetX2 protein | Authors: | Walkiewicz, K, Davlieva, M, Sun, C, Lau, K, Shamoo, Y. | Deposit date: | 2010-10-18 | Release date: | 2011-04-27 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution. Proteins, 79, 2011
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4JYA
| Crystal structures of pseudouridinilated stop codons with ASLs | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | Deposit date: | 2013-03-29 | Release date: | 2013-06-26 | Last modified: | 2013-08-21 | Method: | X-RAY DIFFRACTION (3.098 Å) | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome. Nature, 500, 2013
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4JV5
| Crystal structures of pseudouridinilated stop codons with ASLs | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ... | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | Deposit date: | 2013-03-25 | Release date: | 2013-06-26 | Last modified: | 2013-08-21 | Method: | X-RAY DIFFRACTION (3.162 Å) | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome. Nature, 500, 2013
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4K0K
| Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | Deposit date: | 2013-04-04 | Release date: | 2013-06-26 | Last modified: | 2013-08-21 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome. Nature, 500, 2013
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7CHJ
| crystal structure of pco4 | Descriptor: | CITRIC ACID, FE (III) ION, Plant cysteine oxidase 4 | Authors: | Guo, Q, Xu, C, Liao, S. | Deposit date: | 2020-07-05 | Release date: | 2020-11-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana. J.Struct.Biol., 213, 2021
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7CHI
| crystal structure of pco5 | Descriptor: | FE (III) ION, Plant cysteine oxidase 5 | Authors: | Guo, Q, Xu, C, Liao, S. | Deposit date: | 2020-07-05 | Release date: | 2020-11-25 | Last modified: | 2021-03-31 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana. J.Struct.Biol., 213, 2021
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7CXZ
| crystal structure of pco2 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, NICKEL (II) ION, ... | Authors: | Guo, Q, Xu, C, Liao, S, Chen, Z. | Deposit date: | 2020-09-02 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.561 Å) | Cite: | Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana. J.Struct.Biol., 213, 2021
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5XV7
| SRPK1 in complex with Alectinib | Descriptor: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1 | Authors: | Zeng, C, Ngo, J.C.K. | Deposit date: | 2017-06-26 | Release date: | 2018-03-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform Cell Chem Biol, 25, 2018
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6AGH
| Crystal structure of EFHA1 in Apo-State | Descriptor: | Calcium uptake protein 2, mitochondrial | Authors: | Yangfei, X, Xue, Y, Yuequan, S. | Deposit date: | 2018-08-11 | Release date: | 2019-01-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.742 Å) | Cite: | Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter. Cell Rep, 26, 2019
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6AGJ
| Crystal Structure of EFHA2 in Apo State | Descriptor: | Calcium uptake protein 3, mitochondrial | Authors: | Yangfei, X, Xue, Y, Yuequan, S. | Deposit date: | 2018-08-11 | Release date: | 2019-01-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.999 Å) | Cite: | Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter. Cell Rep, 26, 2019
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6AGI
| Crystal Structure of EFHA2 in Ca-binding State | Descriptor: | CALCIUM ION, Calcium uptake protein 3, mitochondrial, ... | Authors: | Yangfei, X, Xue, Y, Yuequan, S. | Deposit date: | 2018-08-11 | Release date: | 2019-01-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter. Cell Rep, 26, 2019
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7CYI
| Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua | Descriptor: | Alcohol dehydrogenase 1, ZINC ION | Authors: | Feng, X, Fan, S, Lv, G, Li, M, Wu, G, Jin, Y, Yang, Z. | Deposit date: | 2020-09-03 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua To Be Published
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6ICT
| Structure of SETD3 bound to SAH and methylated actin | Descriptor: | Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... | Authors: | Guo, Q, Liao, S, Xu, C, Structural Genomics Consortium (SGC) | Deposit date: | 2018-09-07 | Release date: | 2019-02-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Structural insights into SETD3-mediated histidine methylation on beta-actin. Elife, 8, 2019
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