7SLS

HIV Reverse Transcriptase with compound Pyr02

Summary for 7SLS

• Entry DOI: 10.2210/pdb7sls/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, 5-(difluoromethyl)-3-{[1-{[(3S)-5-fluoro-2-methyl-6-oxo-3,6-dihydropyridin-3-yl]methyl}-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-1,6-dihydropyrimidin-5-yl]oxy}-2-methylbenzonitrile (3 entities in total)
• Functional Keywords: hiv, reverse transcriptase, rt, nnrti, viral protein
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 129904.66

Authors

Klein, D.J.,Zebisch, M.,Gu, M. (deposition date: 2021-10-24, release date: 2022-11-23, Last modification date: 2023-03-29)

• Primary citation: Balibar, C.J.,Klein, D.J.,Zamlynny, B.,Diamond, T.L.,Fang, Z.,Cheney, C.A.,Kristoff, J.,Lu, M.,Bukhtiyarova, M.,Ou, Y.,Xu, M.,Ba, L.,Carroll, S.S.,El Marrouni, A.,Fay, J.F.,Forster, A.,Goh, S.L.,Gu, M.,Krosky, D.,Rosenbloom, D.I.S.,Sheth, P.,Wang, D.,Wu, G.,Zebisch, M.,Zhao, T.,Zuck, P.,Grobler, J.,Hazuda, D.J.,Howell, B.J.,Converso, A.; Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1.; Sci Transl Med, 15:eabn2038-eabn2038, 2023; PubMed: 36812345; DOI: 10.1126/scitranslmed.abn2038

Experimental method

X-RAY DIFFRACTION (2.078 Å)