4KIS
 
 | | Crystal Structure of a LSR-DNA Complex | | Descriptor: | CALCIUM ION, DNA (26-MER), Putative integrase [Bacteriophage A118], ... | | Authors: | Rutherford, K, Yuan, P, Perry, K, Van Duyne, G.D. | | Deposit date: | 2013-05-02 | | Release date: | 2013-07-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Attachment site recognition and regulation of directionality by the serine integrases.
Nucleic Acids Res., 41, 2013
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3BWY
 | | Crystal Structure of Human 108M Catechol O-methyltransferase bound with S-adenosylmethionine and inhibitor dinitrocatechol | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3,5-DINITROCATECHOL, COMT protein, ... | | Authors: | Rutherford, K, Le Trong, I, Stenkamp, R.E, Parson, W.W. | | Deposit date: | 2008-01-10 | | Release date: | 2008-06-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal structures of human 108V and 108M catechol O-methyltransferase.
J.Mol.Biol., 380, 2008
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3BWM
 | | Crystal Structure of Human Catechol O-Methyltransferase with bound SAM and DNC | | Descriptor: | 3,5-DINITROCATECHOL, Catechol O-methyltransferase, MAGNESIUM ION, ... | | Authors: | Rutherford, K, Le Trong, I, Stenkamp, R.E, Parson, W.W. | | Deposit date: | 2008-01-09 | | Release date: | 2008-06-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Crystal structures of human 108V and 108M catechol O-methyltransferase.
J.Mol.Biol., 380, 2008
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5O2D
 | | PARP14 Macrodomain 2 with inhibitor | | Descriptor: | Poly [ADP-ribose] polymerase 14, ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide | | Authors: | Uth, K, Schuller, M, Sieg, C, Wang, J, Krojer, T, Knapp, S, Riedels, K, Bracher, F, Edwards, A.M, Arrowsmith, C, Bountra, C, Elkins, J.M, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-05-20 | | Release date: | 2017-11-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.
ACS Chem. Biol., 12, 2017
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8DNN
 | | Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 80 FAB HEAVY CHAIN, 80 FAB LIGHT CHAIN, ... | | Authors: | Muthuraman, K, Kucharska, I, Ivanochko, D, Julien, J.P. | | Deposit date: | 2022-07-11 | | Release date: | 2023-05-24 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.
Sci Transl Med, 15, 2023
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1CFE
 | | P14A, NMR, 20 STRUCTURES | | Descriptor: | PATHOGENESIS-RELATED PROTEIN P14A | | Authors: | Fernandez, C, Szyperski, T, Bruyere, T, Ramage, P, Mosinger, E, Wuthrich, K. | | Deposit date: | 1996-11-08 | | Release date: | 1997-11-12 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of the pathogenesis-related protein P14a.
J.Mol.Biol., 266, 1997
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3EGF
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5MQF
 | | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX8, Cell division cycle 5-like protein, ... | | Authors: | Bertram, K, Hartmuth, K, Kastner, B. | | Deposit date: | 2016-12-20 | | Release date: | 2017-03-22 | | Last modified: | 2018-11-21 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature, 542, 2017
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2IDY
 | | NMR Structure of the SARS-CoV non-structural protein nsp3a | | Descriptor: | NSP3 | | Authors: | Serrano, P, Almeida, M.S, Johnson, M.A, Horst, R, Herrmann, T, Joseph, J, Saikatendu, K, Subramanian, V, Stevens, R.C, Kuhn, P, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | | Deposit date: | 2006-09-15 | | Release date: | 2006-12-05 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.
J.Virol., 81, 2007
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1T3V
 | | The NMR solution structure of TM1816 | | Descriptor: | conserved hypothetical protein | | Authors: | Columbus, L, Peti, W, Herrmann, T, Etazady, T, Klock, H, Lesley, S, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | | Deposit date: | 2004-04-27 | | Release date: | 2004-12-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima.
Proteins, 60, 2005
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1TAP
 | | NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA | | Descriptor: | FACTOR XA INHIBITOR | | Authors: | Antuch, W, Guntert, P, Billeter, M, Wuthrich, K. | | Deposit date: | 1994-08-16 | | Release date: | 1994-11-30 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata.
FEBS Lett., 352, 1994
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1U5L
 | | Solution Structure of the turtle prion protein fragment (121-226) | | Descriptor: | prion protein | | Authors: | Lysek, D.A, Calzolai, L, Guntert, P, Wuthrich, K. | | Deposit date: | 2004-07-28 | | Release date: | 2005-01-04 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Prion protein NMR structures of chicken, turtle, and frog
PROC.NATL.ACAD.SCI.USA, 102, 2005
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1K9C
 | | Solution Structure of Calreticulin P-domain subdomain (residues 189-261) | | Descriptor: | CALRETICULIN | | Authors: | Ellgaard, L, Bettendorff, P, Braun, D, Herrmann, T, Fiorito, F, Guntert, P, Helenius, A, Wuthrich, K. | | Deposit date: | 2001-10-29 | | Release date: | 2002-10-12 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain
J.Mol.Biol., 322, 2002
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1K91
 | | Solution Structure of Calreticulin P-domain subdomain (residues 221-256) | | Descriptor: | CALRETICULIN | | Authors: | Ellgaard, L, Bettendorff, P, Braun, D, Herrmann, T, Fiorito, F, Guntert, P, Helenius, A, Wuthrich, K. | | Deposit date: | 2001-10-26 | | Release date: | 2002-10-12 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain
J.Mol.Biol., 322, 2002
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1EGF
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1DTK
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1EGO
 | | NMR STRUCTURE OF OXIDIZED ESCHERICHIA COLI GLUTAREDOXIN: COMPARISON WITH REDUCED E. COLI GLUTAREDOXIN AND FUNCTIONALLY RELATED PROTEINS | | Descriptor: | GLUTAREDOXIN | | Authors: | Xia, T.-H, Bushweller, J.H, Sodano, P, Billeter, M, Bjornberg, O, Holmgren, A, Wuthrich, K. | | Deposit date: | 1991-10-08 | | Release date: | 1993-10-31 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | NMR structure of oxidized Escherichia coli glutaredoxin: comparison with reduced E. coli glutaredoxin and functionally related proteins.
Protein Sci., 1, 1992
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1EGR
 | | SEQUENCE-SPECIFIC 1H N.M.R. ASSIGNMENTS AND DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF REDUCED ESCHERICHIA COLI GLUTAREDOXIN | | Descriptor: | GLUTAREDOXIN | | Authors: | Sodano, P, Xia, T.-H, Bushweller, J.H, Bjornberg, O, Holmgren, A, Billeter, M, Wuthrich, K. | | Deposit date: | 1991-10-08 | | Release date: | 1993-10-31 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Sequence-specific 1H n.m.r. assignments and determination of the three-dimensional structure of reduced Escherichia coli glutaredoxin.
J.Mol.Biol., 221, 1991
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1AHD
 | | DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX | | Descriptor: | DNA (5'-D(*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*AP*GP*CP*CP*AP*TP*TP*AP*GP*AP*G)-3'), Homeotic protein antennapedia | | Authors: | Billeter, M, Qian, Y.Q, Otting, G, Muller, M, Gehring, W.J, Wuthrich, K. | | Deposit date: | 1993-04-02 | | Release date: | 1993-10-31 | | Last modified: | 2024-04-10 | | Method: | SOLUTION NMR | | Cite: | Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex.
J.Mol.Biol., 234, 1993
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1E7K
 | | Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment | | Descriptor: | 15.5 KD RNA BINDING PROTEIN, RNA (5'-R(*GP*CP*CP*AP*AP*UP*GP*AP*GP*GP*UP*UP*UP* AP*UP*CP*CP*GP*AP*GP*G*C(-3') | | Authors: | Vidovic, I, Nottrott, S, Harthmuth, K, Luhrmann, R, Ficner, R. | | Deposit date: | 2000-08-29 | | Release date: | 2001-02-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structure of the Spliceosomal 15.5Kd Protein Bound to a U4 Snrna Fragment
Mol.Cell, 6, 2000
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4AIT
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1MRB
 | | THREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD7 METALLOTHIONEIN-2A IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE | | Descriptor: | CADMIUM ION, CD7 METALLOTHIONEIN-2A | | Authors: | Braun, W, Arseniev, A, Schultze, P, Woergoetter, E, Wagner, G, Vasak, M, Kaegi, J.H.R, Wuthrich, K. | | Deposit date: | 1990-05-14 | | Release date: | 1991-04-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional structure of rabbit liver [Cd7]metallothionein-2a in aqueous solution determined by nuclear magnetic resonance.
J.Mol.Biol., 201, 1988
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1BUS
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1MRT
 | | CONFORMATION OF CD-7 METALLOTHIONEIN-2 FROM RAT LIVER IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | | Descriptor: | CADMIUM ION, CD7 METALLOTHIONEIN-2 | | Authors: | Braun, W, Schultze, P, Woergoetter, E, Wagner, G, Vasak, M, Kaegi, J.H.R, Wuthrich, K. | | Deposit date: | 1990-05-14 | | Release date: | 1991-04-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Conformation of [Cd7]-metallothionein-2 from rat liver in aqueous solution determined by nuclear magnetic resonance spectroscopy.
J.Mol.Biol., 203, 1988
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8FX3
 | | Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-GP, showing the structure of the complete active site in its open conformation | | Descriptor: | Hypoxanthine-guanine phosphoribosyltransferase, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER | | Authors: | Hughes, R, Meneely, K.M, Glockzin, K, Suthagar, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A. | | Deposit date: | 2023-01-23 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
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