3BWM

Crystal Structure of Human Catechol O-Methyltransferase with bound SAM and DNC

Summary for 3BWM

Entry DOI	10.2210/pdb3bwm/pdb
Descriptor	Catechol O-methyltransferase, MAGNESIUM ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	comt, rossmann fold, sam, dnc, alternative initiation, catecholamine metabolism, cytoplasm, magnesium, membrane, methyltransferase, neurotransmitter degradation, polymorphism, s-adenosyl-l-methionine, transferase, transmembrane
Biological source	Homo sapiens (Human)
Cellular location	Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side: P21964
Total number of polymer chains	1
Total formula weight	24510.34
Authors	Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W. (deposition date: 2008-01-09, release date: 2008-06-03, Last modification date: 2023-08-30)
Primary citation	Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W. Crystal structures of human 108V and 108M catechol O-methyltransferase. J.Mol.Biol., 380:120-130, 2008 Cited by PubMed: 18486144 DOI: 10.1016/j.jmb.2008.04.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation