5X2L
| Crystal Structure of Human Serine Racemase | 分子名称: | MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Serine racemase | 著者 | Obita, T, Matsumoto, K, Mori, H, Toyooka, N, Mizuguchi, M. | 登録日 | 2017-02-01 | 公開日 | 2018-01-31 | 最終更新日 | 2021-02-24 | 実験手法 | X-RAY DIFFRACTION (1.806 Å) | 主引用文献 | Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase. Bioorg. Med. Chem. Lett., 2017
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7C7H
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7C7F
| Crystal structures of AKR1C3 binary complex with NADP+ | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C3, ... | 著者 | Irie, K, Toyooka, N, Endo, S. | 登録日 | 2020-05-25 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer. J.Med.Chem., 63, 2020
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7C7G
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7W9Q
| Crystal structure of V30M-TTR in complex with naringenin derivative-14 | 分子名称: | (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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7W9R
| Crystal structure of V30M-TTR in complex with naringenin derivative-18 | 分子名称: | (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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8II3
| Crystal structure of V30M-TTR in complex with 6-hydroxy BID | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
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8II1
| Crystal structure of V30M-TTR in complex with BID | 分子名称: | Benziodarone, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.907 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
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8II4
| Crystal structure of V30M-TTR in complex with 6-hydroxy BBM | 分子名称: | Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
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8II2
| Crystal structure of V30M-TTR in complex with BBM | 分子名称: | CALCIUM ION, Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
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8IG1
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7DT8
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7DT3
| Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | 分子名称: | 4-chloranyl-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid, CALCIUM ION, Transthyretin | 著者 | Kitakami, R, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-01-04 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.198 Å) | 主引用文献 | Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem., 44, 2021
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7DT5
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7DT6
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7EJQ
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7EJR
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