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5VOV
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Structure of AMPA receptor-TARP complex
分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
著者Zhao, Y, Chen, S, Wang, Y.S, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2017-05-03
公開日2017-07-12
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (7.7 Å)
主引用文献Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Cell, 170, 2017
5U4I
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BU of 5u4i by Molmil
Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Zeng, F, Chen, Y, Remis, J, Shekhar, M, Phillips, J.C, Tajkhorshid, E, Jin, H.
登録日2016-12-04
公開日2017-01-11
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome.
Nature, 541, 2017
5U4J
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Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S12, ...
著者Zeng, F, Chen, Y, Remis, J, Shekhar, M, Phillips, J.C, Tajkhorshid, E, Jin, H.
登録日2016-12-04
公開日2017-01-11
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome.
Nature, 541, 2017
5WGD
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BU of 5wgd by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1
分子名称: (ACE)AILHKLLQDS(NH2), (ACE)HKILHKLLQDS(NH2), ESTRADIOL, ...
著者Fanning, S.W, Speltz, T.E, Mayne, C.G, Siddiqui, Z, Greene, G.L, Tajkhorshid, E, Moore, T.W.
登録日2017-07-14
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A "cross-stitched" peptide with improved helicity and proteolytic stability.
Org. Biomol. Chem., 16, 2018
1LDF
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CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) MUTATION W48F, F200T
分子名称: GLYCEROL, Glycerol uptake facilitator protein, MAGNESIUM ION, ...
著者Nollert, P, Miercke, L.J.W, O'Connell, J, Stroud, R.M.
登録日2002-04-08
公開日2002-05-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Control of the selectivity of the aquaporin water channel family by global orientational tuning.
Science, 296, 2002
1LDA
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CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITHOUT SUBSTRATE GLYCEROL
分子名称: Glycerol uptake facilitator protein, octyl beta-D-glucopyranoside
著者Nollert, P, Miercke, L.J.W, O'Connell, J, Stroud, R.M.
登録日2002-04-08
公開日2002-05-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Control of the selectivity of the aquaporin water channel family by global orientational tuning.
Science, 296, 2002
1LDI
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CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITHOUT SUBSTRATE GLYCEROL
分子名称: Glycerol uptake facilitator protein, octyl beta-D-glucopyranoside
著者Nollert, P, Miercke, L.J.W, O'Connell, J, Stroud, R.M.
登録日2002-04-08
公開日2002-05-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Control of the selectivity of the aquaporin water channel family by global orientational tuning.
Science, 296, 2002
4XI3
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Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene
分子名称: Bazedoxifene, Estrogen receptor
著者Fanning, S.W, Mayne, C.G, Toy, W, Carlson, K, Greene, B, Nowak, J, Walter, R, Panchamukhi, S, Tajhorshid, E, Nettles, K.W, Chandarlapaty, S, Katzenellenbogen, J, Greene, G.L.
登録日2015-01-06
公開日2016-01-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Elife, 7, 2018
7N9Z
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E. coli cytochrome bo3 in MSP nanodisc
分子名称: 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ...
著者Vallese, F, Clarke, O.B.
登録日2021-06-19
公開日2021-09-01
実験手法ELECTRON MICROSCOPY (2.19 Å)
主引用文献Cryo-EM structures of Escherichia coli cytochrome bo 3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site.
Proc.Natl.Acad.Sci.USA, 118, 2021
8FHK
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Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Tang, Q, Mchaourab, H.
登録日2022-12-14
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8FMV
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Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-2HT/ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Tang, Q, Mchaourab, H.
登録日2022-12-24
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
7USX
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BU of 7usx by Molmil
Structure of Contracted C. elegans TMC-1 complex
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jeong, H, Clark, S, Gouaux, E.
登録日2022-04-26
公開日2022-10-19
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7USW
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Structure of Expanded C. elegans TMC-1 complex
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jeong, H, Clark, S, Gouaux, E.
登録日2022-04-26
公開日2022-10-19
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7USY
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BU of 7usy by Molmil
Structure of C. elegans TMC-1 complex with ARRD-6
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jeong, H, Clark, S, Gouaux, E.
登録日2022-04-26
公開日2022-10-19
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
6RHY
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Structure of pore-forming amyloid-beta tetramers
分子名称: Amyloid beta A4 protein
著者Bardiaux, B, Ciudad, S, Carulla, N.
登録日2019-04-23
公開日2019-09-25
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献A beta (1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.
Nat Commun, 11, 2020
8T1P
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Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ADPVi: BmrCD_OC-ADPVi
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ...
著者Tang, Q, Mchaourab, H.S.
登録日2023-06-02
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8SZC
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BU of 8szc by Molmil
Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-1HT/ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Tang, Q, Mchaourab, H.
登録日2023-05-29
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8T3K
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Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ...
著者Tang, Q, Mchaourab, H.
登録日2023-06-07
公開日2023-11-29
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8FPT
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STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE
分子名称: Alpha-synuclein
著者Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D.
登録日2023-01-05
公開日2023-02-22
最終更新日2024-05-15
実験手法SOLID-STATE NMR
主引用文献Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Biorxiv, 2023
6D9G
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X-ray Structure of the FAB Fragment of 15B8, a Murine Monoclonal Antibody Specific for the Human Serotonin Transporter
分子名称: Antibody heavy chain Fab, Antibody light chain Fab
著者Coleman, J.A, Yang, D, Gouaux, E.
登録日2018-04-29
公開日2019-04-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
5HD8
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Crystal structure of disulfide cross-linked D417C ClC-ec1
分子名称: CHLORIDE ION, FAB FRAGMENT (HEAVY CHAIN), FAB FRAGMENT (LIGHT CHAIN), ...
著者Mathews, I.I, Khantwal, C.M, Maduke, M.
登録日2016-01-05
公開日2017-01-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Conformational change in CLC transporters: beyond the rotation of Gluex
To be published
6DZY
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BU of 6dzy by Molmil
Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine
分子名称: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
著者Coleman, J.A, Yang, D, Gouaux, E.
登録日2018-07-05
公開日2019-04-24
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZV
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Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded conformation
分子名称: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
著者Coleman, J.A, Yang, D, Gouaux, E.
登録日2018-07-05
公開日2019-04-24
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZZ
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Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation
分子名称: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
著者Yang, D, Coleman, J.A, Gouaux, E.
登録日2018-07-05
公開日2019-04-24
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZW
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Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and 15B8 Fab and 8B6 ScFv
分子名称: 15B8 antibody heavy chain, 15B8 antibody light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Coleman, J.A, Yang, D, Gouaux, E.
登録日2018-07-05
公開日2019-04-24
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019

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