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DPP9 IN COMPLEX WITH LIGAND ICeD-1
Descriptor:	(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 9
Authors:	Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:	2021-11-19
Release date:	2022-10-05
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.78 Å)
Cite:	A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022

7SVO

DPP8 IN COMPLEX WITH LIGAND ICeD-1
Descriptor:	(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 8, trimethylamine oxide
Authors:	Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:	2021-11-19
Release date:	2022-10-05
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.58 Å)
Cite:	A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022

7FJO

Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with three T6 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, T6 heavy chain, ...
Authors:	Wang, X, Zhang, L, Zhang, S, Liang, Q.
Deposit date:	2021-08-04
Release date:	2022-04-13
Method:	ELECTRON MICROSCOPY (3.34 Å)
Cite:	RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022

7FJN

Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ...
Authors:	Wang, X, Zhang, L, Zhang, S, Liang, Q.
Deposit date:	2021-08-04
Release date:	2022-04-27
Method:	ELECTRON MICROSCOPY (3.25 Å)
Cite:	RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022

5TRF

MDM2 in complex with SAR405838
Descriptor:	(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ...
Authors:	Meagher, J.L, Stuckey, J.A.
Deposit date:	2016-10-26
Release date:	2016-11-09
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res., 74, 2014

7FJS

Crystal structure of T6 Fab bound to theSARS-CoV-2 RBD of B.1.351
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, T6 heavy chain, ...
Authors:	Wang, X, Zhang, L, Zhang, S, Liang, Q.
Deposit date:	2021-08-04
Release date:	2022-04-27
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022

7WIH

Cryo-EM structure of LY2794193-bound mGlu3
Descriptor:	(1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:	Fang, W, Yang, F, Xu, C.J, Ling, S.L, Lin, L, Zhou, Y.X, Sun, W.J, Wang, X.M, Liu, P, Rondard, P, Pan, S, Pin, J.P, Tian, C.L, Liu, J.F.
Deposit date:	2022-01-03
Release date:	2022-03-16
Last modified:	2022-07-20
Method:	ELECTRON MICROSCOPY (3.68 Å)
Cite:	Structural basis of the activation of metabotropic glutamate receptor 3. Cell Res., 32, 2022

7WI6

Cryo-EM structure of LY341495/NAM-bound mGlu3
Descriptor:	2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:	Fang, W, Yang, F, Xu, C.J, Ling, S.L, Lin, L, Zhou, Y.X, Sun, W.J, Wang, X.M, Liu, P, Rondard, P, Pan, S, Pin, J.P, Tian, C.L, Liu, J.F.
Deposit date:	2022-01-03
Release date:	2022-03-16
Last modified:	2022-07-20
Method:	ELECTRON MICROSCOPY (3.71 Å)
Cite:	Structural basis of the activation of metabotropic glutamate receptor 3. Cell Res., 32, 2022

7WI8

Cryo-EM structure of inactive mGlu3 bound to LY341495
Descriptor:	2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:	Fang, W, Yang, F, Xu, C.J, Ling, S.L, Lin, L, Zhou, Y.X, Sun, W.J, Wang, X.M, Liu, P, Rondard, P, Pan, S, Pin, J.P, Tian, C.L, Liu, J.F.
Deposit date:	2022-01-03
Release date:	2022-03-16
Last modified:	2022-07-20
Method:	ELECTRON MICROSCOPY (4.17 Å)
Cite:	Structural basis of the activation of metabotropic glutamate receptor 3. Cell Res., 32, 2022

6JYJ

Crystal structure of FAM46B (TENT5B)
Descriptor:	CITRATE ANION, Terminal nucleotidyltransferase 5B
Authors:	Zhang, H, Hu, J.L, Gao, S.
Deposit date:	2019-04-26
Release date:	2020-03-04
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.693199 Å)
Cite:	FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res., 48, 2020

3RO4

X-ray Structure of Ketohexokinase in complex with an indazole compound derivative
Descriptor:	3-ethyl-6-[(3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-1-phenyl-1H-indazole, Ketohexokinase, SULFATE ION
Authors:	Abad, M.C, Gibbs, A.C.
Deposit date:	2011-04-25
Release date:	2011-08-03
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors. Bioorg.Med.Chem.Lett., 21, 2011

3KMP

Crystal Structure of SMAD1-MH1/DNA complex
Descriptor:	5'-D(PAPTPCPAPGPTPCPTPAPGPAPCPAPTPA)-3', 5'-D(PGPTPAPTPGPTPCPTPAPGPAPCPTPGPA)-3', GLYCEROL, ...
Authors:	Baburajendran, N, Palasingam, P, Narasimhan, K, Jauch, R, Kolatkar, P.R.
Deposit date:	2009-11-11
Release date:	2010-02-23
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors. Nucleic Acids Res., 38, 2010

3NBW

X-ray structure of ketohexokinase in complex with a pyrazole compound
Descriptor:	5-amino-3-(methylsulfanyl)-1-phenyl-1H-pyrazole-4-carbonitrile, GLYCEROL, Ketohexokinase, ...
Authors:	Abad, M.C, Gibbs, A.C, Spurlino, J.C.
Deposit date:	2010-06-04
Release date:	2010-12-22
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.341 Å)
Cite:	Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010

3NC2

X-ray structure of ketohexokinase with a quinazoline
Descriptor:	Ketohexokinase, SULFATE ION, quinazoline
Authors:	Abad, M.C, Gibbs, A.C, Spurlino, J.C.
Deposit date:	2010-06-04
Release date:	2010-12-22
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010

3NC9

X-ray structure of ketohexokinase complexed with an indazole compound
Descriptor:	Ketohexokinase, N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]piperidine-4-carboxamide, SULFATE ION
Authors:	Abad, M.C, Gibbs, A.C, Spurlino, J.C.
Deposit date:	2010-06-04
Release date:	2010-12-22
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010

3NBV

X-ray Structure of Ketohexokinase in complex with AMP-PNP and fructose
Descriptor:	Ketohexokinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ...
Authors:	Abad, M.C, Gibbs, A.C.
Deposit date:	2010-06-04
Release date:	2010-12-22
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010

3NCA

X-ray structure of ketohexokinase in complex with a thieno pyridinol compound
Descriptor:	Ketohexokinase, SULFATE ION, thieno[3,2-b]pyridin-7-ol
Authors:	Abad, M.C, Gibbs, A.C, Spurlino, J.C.
Deposit date:	2010-06-04
Release date:	2010-12-22
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.602 Å)
Cite:	Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010

3O0I

Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54
Descriptor:	8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, HSP90AA1 protein
Authors:	Seidler, P.M, Gewirth, D.T.
Deposit date:	2010-07-19
Release date:	2011-10-05
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.47 Å)
Cite:	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9, 2013

3O2F

Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
Descriptor:	8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, Endoplasmin, GLYCEROL, ...
Authors:	Seidler, P.M, Gewirth, D.T.
Deposit date:	2010-07-22
Release date:	2011-10-05
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9, 2013

7DTT

Human Calcium-Sensing Receptor bound with calcium ions
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Sun, D.M, Liu, L, Shi, C.W.
Deposit date:	2021-01-06
Release date:	2021-03-10
Last modified:	2021-04-14
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021

7DTV

Human Calcium-Sensing Receptor bound with L-Trp and calcium ions
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W.
Deposit date:	2021-01-06
Release date:	2021-03-10
Last modified:	2021-04-14
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021

7DTW

Human Calcium-Sensing Receptor in the inactive close-close conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular calcium-sensing receptor
Authors:	Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W.
Deposit date:	2021-01-06
Release date:	2021-03-10
Last modified:	2021-04-14
Method:	ELECTRON MICROSCOPY (4.5 Å)
Cite:	Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021

7DTU

Human Calcium-Sensing Receptor bound with L-Trp
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular calcium-sensing receptor, ...
Authors:	Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W.
Deposit date:	2021-01-06
Release date:	2021-03-10
Last modified:	2021-04-14
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021

1A11

NMR STRUCTURE OF MEMBRANE SPANNING SEGMENT 2 OF THE ACETYLCHOLINE RECEPTOR IN DPC MICELLES, 10 STRUCTURES
Descriptor:	ACETYLCHOLINE RECEPTOR M2
Authors:	Gesell, J.J, Sun, W, Montal, M, Opella, S.J.
Deposit date:	1997-12-19
Release date:	1998-04-08
Last modified:	2022-02-16
Method:	SOLUTION NMR
Cite:	Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat.Struct.Biol., 6, 1999

7CI1

Crystal structure of AcrVA2
Descriptor:	1,2-ETHANEDIOL, AcrVA2, SPERMIDINE
Authors:	Chen, P, Cheng, Z, Wang, Y.
Deposit date:	2020-07-07
Release date:	2020-10-14
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural Study on Anti-CRISPR Protein AcrVA2 Prog.Biochem.Biophys., 2021

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Displayed results:	25
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