7DTW

Human Calcium-Sensing Receptor in the inactive close-close conformation

Summary for 7DTW

Entry DOI	10.2210/pdb7dtw/pdb
Related	7DTT 7DTU 7DTV
EMDB information	30856
Descriptor	Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	gpcr, class c, calcium sensing receptor, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	250066.51
Authors	Ling, S.L.,Tian, C.L.,Shi, P.,Liu, S.L.,Meng, X.Y.,Liu, L.,Sun, D.M.,Shi, C.W. (deposition date: 2021-01-06, release date: 2021-03-10, Last modification date: 2021-04-14)
Primary citation	Ling, S.,Shi, P.,Liu, S.,Meng, X.,Zhou, Y.,Sun, W.,Chang, S.,Zhang, X.,Zhang, L.,Shi, C.,Sun, D.,Liu, L.,Tian, C. Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31:383-394, 2021 Cited by PubMed: 33603117 DOI: 10.1038/s41422-021-00474-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.5 Å)

Structure validation