5WG5
| Human GRK2 in complex with Gbetagamma subunits and CCG224061 | Descriptor: | 5-{[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-2H-indazole, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Bouley, R, Tesmer, J.J.G. | Deposit date: | 2017-07-13 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
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5WG4
| Human GRK2 in complex with Gbetagamma subunits and CCG257284 | Descriptor: | 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl)oxy]methyl}piperidin-4-yl]-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Bouley, R, Tesmer, J.J.G. | Deposit date: | 2017-07-13 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
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4J1N
| Crystal structures of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold | Descriptor: | 1-(4-methoxy-3-methylbenzyl)-1,5,6,7-tetrahydroindeno[5,6-d]imidazole, Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL, ... | Authors: | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | Deposit date: | 2013-02-01 | Release date: | 2014-07-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). Bioorg.Med.Chem.Lett., 25, 2015
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7C01
| Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CB6 heavy chain, CB6 light chain, ... | Authors: | Shi, R, Qi, J, Wang, Q, Gao, F.G, Yan, J. | Deposit date: | 2020-04-29 | Release date: | 2020-05-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature, 584, 2020
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8K37
| Structure of the bacteriophage lambda neck | Descriptor: | Head-tail connector protein FII, Tail tube protein, Tail tube terminator protein | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | Deposit date: | 2023-07-14 | Release date: | 2023-11-15 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8K38
| The structure of bacteriophage lambda portal-adaptor | Descriptor: | Head completion protein, Portal protein B | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | Deposit date: | 2023-07-14 | Release date: | 2023-11-15 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8K39
| Structure of the bacteriophage lambda portal vertex | Descriptor: | Major capsid protein, Portal protein B | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | Deposit date: | 2023-07-14 | Release date: | 2023-11-15 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8K36
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8K35
| Structure of the bacteriophage lambda tail tip complex | Descriptor: | IRON/SULFUR CLUSTER, Tail tip assembly protein I, Tail tip protein L, ... | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | Deposit date: | 2023-07-14 | Release date: | 2023-11-15 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly. Plos Biol., 21, 2023
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8ZVI
| Structure of the bacteriophage T5 capsid | Descriptor: | Decoration protein, Major capsid protein | Authors: | Peng, Y, Liu, H.R. | Deposit date: | 2024-06-11 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of Mature and Urea-Treated Empty Bacteriophage T5: Insights into Siphophage Infection and DNA Ejection. Int J Mol Sci, 25, 2024
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6V3W
| Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397 | Descriptor: | 5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one, CHLORIDE ION, Protein mono-ADP-ribosyltransferase PARP12 | Authors: | Swinger, K.K, Gozgit, J.M, Vasbinder, M.M, Wigle, T.J, Kuntz, K.W. | Deposit date: | 2019-11-26 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell, 39, 2021
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2I9Y
| Solution structure of Arabidopsis thaliana protein At1g70830, a member of the major latex protein family | Descriptor: | major latex protein-like protein 28 or MLP-like protein 28 | Authors: | Volkman, B.F, de la Cruz, N.B, Lytle, B.L, Peterson, F.C, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2006-09-06 | Release date: | 2006-09-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structures of two Arabidopsis thaliana major latex proteins represent novel helix-grip folds. Proteins, 76, 2009
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5GZR
| Zika virus E protein complexed with a neutralizing antibody Z23-Fab | Descriptor: | Z23 Fab heavy chain, Z23 Fab light chain, structural protein E, ... | Authors: | Gao, G.G, Shi, Y, Peng, R, Liu, S. | Deposit date: | 2016-10-01 | Release date: | 2016-11-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (9.4 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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4ICQ
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4K6J
| Human cohesin inhibitor WapL | Descriptor: | ACETATE ION, SULFATE ION, Wings apart-like protein homolog | Authors: | Tomchick, D.R, Yu, H, Ouyang, Z. | Deposit date: | 2013-04-16 | Release date: | 2013-06-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6205 Å) | Cite: | Structure of the human cohesin inhibitor Wapl. Proc.Natl.Acad.Sci.USA, 110, 2013
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4ICS
| Crystal structure of PepS from Streptococcus pneumoniae in complex with a substrate | Descriptor: | Aminopeptidase PepS, GLYCINE, TRYPTOPHAN, ... | Authors: | Lee, S, Kim, K.K, Ta, M.H. | Deposit date: | 2012-12-11 | Release date: | 2013-10-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure-based elucidation of the regulatory mechanism for aminopeptidase activity. Acta Crystallogr.,Sect.D, 69, 2013
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4ICR
| Structural basis for substrate recognition and reaction mechanism of bacterial aminopeptidase peps | Descriptor: | Aminopeptidase PepS, CACODYLATE ION, ZINC ION | Authors: | Lee, S, Kim, K.K, Ta, M.H. | Deposit date: | 2012-12-11 | Release date: | 2013-10-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structure-based elucidation of the regulatory mechanism for aminopeptidase activity. Acta Crystallogr.,Sect.D, 69, 2013
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8WRJ
| glycosyltransferase UGT74AN3 | Descriptor: | 5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE | Authors: | Huang, W, Long, F. | Deposit date: | 2023-10-15 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
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8WRK
| glycosyltransferase UGT74AN3 | Descriptor: | Glycosyltransferase, PICEATANNOL, URIDINE-5'-DIPHOSPHATE | Authors: | Huang, W, Long, F. | Deposit date: | 2023-10-15 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
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9FE6
| Short-chain dehydrogenase/reductase (SDR) from Thermus caliditerrae | Descriptor: | MAGNESIUM ION, SDR family oxidoreductase | Authors: | Kapur, B, Nar, H. | Deposit date: | 2024-05-17 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.875 Å) | Cite: | In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering Front Chem Biol, 2024
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8WM9
| Fzd4/DEP complex | Descriptor: | CHOLESTEROL HEMISUCCINATE, Frizzled-4, Segment polarity protein dishevelled homolog DVL-2 | Authors: | He, Y, Qian, Y. | Deposit date: | 2023-10-03 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation. Nat Commun, 15, 2024
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8WMA
| Fzd4/DEP complex (local refined) | Descriptor: | Frizzled-4, Segment polarity protein dishevelled homolog DVL-2 | Authors: | He, Y, Qian, Y. | Deposit date: | 2023-10-03 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation. Nat Commun, 15, 2024
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9FEB
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5GV5
| Crystal structure of Candida antarctica Lipase B with active Ser105 modified with a phosphonate inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lipase B, ... | Authors: | Park, S.Y, Lee, H. | Deposit date: | 2016-09-02 | Release date: | 2017-09-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structural and Experimental Evidence for the Enantiomeric Recognition toward a Bulky sec-Alcohol by Candida antarctica Lipase B Acs Catalysis, 6, 2016
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7X08
| S protein of SARS-CoV-2 in complex with 2G1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | Authors: | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | Deposit date: | 2022-02-21 | Release date: | 2022-03-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD. Cell Discov, 8, 2022
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