6V3W

Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397

Summary for 6V3W

• Entry DOI: 10.2210/pdb6v3w/pdb
• Descriptor: Protein mono-ADP-ribosyltransferase PARP12, 5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: adp-ribosyltransferase activity, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23174.14

Authors

Swinger, K.K.,Gozgit, J.M.,Vasbinder, M.M.,Wigle, T.J.,Kuntz, K.W. (deposition date: 2019-11-26, release date: 2020-12-16, Last modification date: 2023-10-11)

• Primary citation: Gozgit, J.M.,Vasbinder, M.M.,Abo, R.P.,Kunii, K.,Kuplast-Barr, K.G.,Gui, B.,Lu, A.Z.,Molina, J.R.,Minissale, E.,Swinger, K.K.,Wigle, T.J.,Blackwell, D.J.,Majer, C.R.,Ren, Y.,Niepel, M.,Varsamis, Z.A.,Nayak, S.P.,Bamberg, E.,Mo, J.R.,Church, W.D.,Mady, A.S.A.,Song, J.,Utley, L.,Rao, P.E.,Mitchison, T.J.,Kuntz, K.W.,Richon, V.M.,Keilhack, H.; PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.; Cancer Cell, 39:1214-1226.e10, 2021; PubMed: 34375612; DOI: 10.1016/j.ccell.2021.06.018

Experimental method

X-RAY DIFFRACTION (2.04 Å)