6V3W

Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue QO4 A 701

Chain	Residue
A	HIS564
A	TYR596
A	PHE597
A	ALA598
A	TYR603
A	SER604
A	PHE607
A	GLY565
A	ILE569
A	GLY573
A	ILE574
A	ASN578
A	PHE579
A	ASP580
A	SER595

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 702

Chain	Residue
A	PHE579
A	TRP581
A	SER595

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: ADP-ribosyl aspartic acid => ECO:0000269|PubMed:25043379

Chain	Residue	Details
A	ASP600
A	ASP611

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