6V3W
Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein mono-ADP-ribosyltransferase PARP12 | polymer | 198 | 22615.3 | 1 | UniProt (Q9H0J9) Pfam (PF00644) In PDB | Homo sapiens (Human) | ADP-ribosyltransferase diphtheria toxin-like 12,ARTD12,Poly [ADP-ribose] polymerase 12,PARP-12,Zinc finger CCCH domain-containing protein 1 |
| 2 | A | 5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one | non-polymer | 523.4 | 1 | Chemie (QO4) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 489 - 684 (UniProt: Q9H0J9)
| PDB | External Database | Details |
|---|---|---|
| Ser 487 | - | expression tag |
| Met 488 | - | expression tag |
| Val 570 | Phe 570 | engineered mutation |
| Gly 573 | Ala 573 | engineered mutation |
| His 577 | Gln 577 | engineered mutation |
| Phe 607 | Tyr 607 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22615.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 558.9 | |
| All* | Total formula weight | 23174.1 |
