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3BX7
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BU of 3bx7 by Molmil
Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
Descriptor: CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2
Authors:Schonfeld, D.L, Chatwell, L, Skerra, A.
Deposit date:2008-01-11
Release date:2009-01-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published
1RST
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BU of 1rst by Molmil
COMPLEX BETWEEN STREPTAVIDIN AND THE STREP-TAG PEPTIDE
Descriptor: STREP-TAG PEPTIDE, STREPTAVIDIN
Authors:Koepke, J, Schmidt, T, Skerra, A.
Deposit date:1995-10-19
Release date:1997-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin.
J.Mol.Biol., 255, 1996
1RSU
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BU of 1rsu by Molmil
COMPLEX BETWEEN STREPTAVIDIN AND THE STREP-TAG II PEPTIDE
Descriptor: STREP-TAG II PEPTIDE, STREPTAVIDIN
Authors:Koepke, J, Schmidt, T, Skerra, A.
Deposit date:1995-10-19
Release date:1997-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin.
J.Mol.Biol., 255, 1996
5E9O
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BU of 5e9o by Molmil
Spirochaeta thermophila X module - CBM64 - mutant G504A
Descriptor: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Cellulase, glycosyl hydrolase family 5, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2015-10-15
Release date:2016-03-02
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila.
Proteins, 84, 2016
5E9P
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BU of 5e9p by Molmil
Spirochaeta thermophila X module - CBM64 - wildtype
Descriptor: Cellulase, glycosyl hydrolase family 5, TPS linker, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2015-10-15
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila.
Proteins, 84, 2016
6I9Q
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BU of 6i9q by Molmil
Structure of the mouse CD98 heavy chain ectodomain
Descriptor: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, CHLORIDE ION
Authors:Schiefner, A, Deuschle, F.-C, Skerra, A.
Deposit date:2018-11-24
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural differences between the ectodomains of murine and human CD98hc.
Proteins, 87, 2019
6YJW
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BU of 6yjw by Molmil
Structure of Fragaria ananassa O-methyltransferase crystallized with PAS polypeptide
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, O-methyltransferase, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2020-04-05
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Proline/alanine-rich sequence (PAS) polypeptides as an alternative to PEG precipitants for protein crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6YJX
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BU of 6yjx by Molmil
Structure of Hen egg-white lysozyme crystallized with PAS polypeptide
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2020-04-05
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Proline/alanine-rich sequence (PAS) polypeptides as an alternative to PEG precipitants for protein crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
5BPK
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BU of 5bpk by Molmil
Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
Descriptor: (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid, 1,2-ETHANEDIOL, Gamma-glutamyltranspeptidase (Ggt)
Authors:Bolz, C, Bach, N.C, Meyer, H, Mueller, G, Dawidowski, M, Popowicz, G, Sieber, S.A, Skerra, A, Gerhard, M.
Deposit date:2015-05-28
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
To Be Published
1SG2
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BU of 1sg2 by Molmil
Crystal structure of the periplasmic chaperone Skp
Descriptor: Seventeen Kilodalton Protein
Authors:Korndorfer, I.P, Dommel, M.K, Skerra, A.
Deposit date:2004-02-23
Release date:2004-09-14
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the periplasmic chaperone Skp suggests functional similarity with cytosolic chaperones despite differing architecture.
Nat.Struct.Mol.Biol., 11, 2004
1KXO
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BU of 1kxo by Molmil
ENGINEERED LIPOCALIN DIGA16 : APO-FORM
Descriptor: DigA16
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2002-02-01
Release date:2003-06-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.
J.Mol.Biol., 330, 2003
1LKE
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BU of 1lke by Molmil
ENGINEERED LIPOCALIN DIGA16 IN COMPLEX WITH DIGOXIGENIN
Descriptor: DIGOXIGENIN, DigA16
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2002-04-25
Release date:2003-06-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.
J.Mol.Biol., 330, 2003
2HZR
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BU of 2hzr by Molmil
Crystal structure of human apolipoprotein D (ApoD)
Descriptor: Apolipoprotein D
Authors:Eichinger, A, Skerra, A.
Deposit date:2006-08-09
Release date:2007-08-14
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d.
J.Biol.Chem., 282, 2007
1PKQ
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BU of 1pkq by Molmil
Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex
Descriptor: (8-18C5) chimeric Fab, heavy chain, light chain, ...
Authors:Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U.
Deposit date:2003-06-06
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
Proc.Natl.Acad.Sci.USA, 100, 2003
2HZQ
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BU of 2hzq by Molmil
Crystal structure of human apolipoprotein D (ApoD) in complex with progesterone
Descriptor: Apolipoprotein D, PROGESTERONE
Authors:Eichinger, A, Skerra, A.
Deposit date:2006-08-09
Release date:2007-08-14
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d.
J.Biol.Chem., 282, 2007
1PKO
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BU of 1pko by Molmil
Myelin Oligodendrocyte Glycoprotein (MOG)
Descriptor: Myelin Oligodendrocyte Glycoprotein
Authors:Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U.
Deposit date:2003-06-06
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
Proc.Natl.Acad.Sci.USA, 100, 2003
7O31
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BU of 7o31 by Molmil
Crystal structure of the anti-PAS Fab 1.2 in complex with its epitope peptide and the anti-Kappa VHH domain
Descriptor: 1,2-ETHANEDIOL, PAS#1 epitope peptide, anti-Kappa VHH domain, ...
Authors:Schilz, J, Schiefner, A, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
7O2Z
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BU of 7o2z by Molmil
Crystal structure of the anti-PAS Fab 2.2 in complex with its epitope peptide
Descriptor: CHLORIDE ION, P/A#1 epitope peptide, anti-PAS Fab 2.2 chimeric heavy chain, ...
Authors:Schilz, J, Schiefner, A, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
7O30
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BU of 7o30 by Molmil
Crystal structure of the anti-PAS Fab 1.1 in complex with its epitope peptide
Descriptor: PAS#1 epitope peptide, anti-PAS Fab 1.1 chimeric heavy chain, anti-PAS Fab 1.1 chimeric light chain
Authors:Schilz, J, Schiefner, A, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
5N47
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BU of 5n47 by Molmil
Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
7O33
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BU of 7o33 by Molmil
Crystal structure of the anti-PAS Fab 3.1 in complex with its epitope peptide
Descriptor: APSA epitope peptide, anti-PAS Fab 3.1 chimeric heavy chain, anti-PAS Fab 3.1 chimeric light chain
Authors:Schilz, J, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
4MVL
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BU of 4mvl by Molmil
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVK
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BU of 4mvk by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED
Descriptor: Amyloid peptide fragment VFFAED, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVI
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BU of 4mvi by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
3DDY
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BU of 3ddy by Molmil
Structure of lumazine protein, an optical transponder of luminescent bacteria
Descriptor: Lumazine protein, RIBOFLAVIN
Authors:Chatwell, L, Illarionova, V, Illarionov, B, Skerra, A, Bacher, A, Fischer, M.
Deposit date:2008-06-07
Release date:2008-07-01
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of lumazine protein, an optical transponder of luminescent bacteria.
J.Mol.Biol., 382, 2008

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