7XMD
 
 | | Cryo-EM structure of Cytochrome bo3 from Escherichia coli, the structure complexed with an allosteric inhibitor N4 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | | 著者 | Nishida, Y, Shigematsu, H, Iwamoto, T, Takashima, S, Shintani, Y. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
|
|
5XON
 | | RNA Polymerase II elongation complex bound with Spt4/5 and TFIIS | | 分子名称: | DNA (48-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Ehara, H, Yokoyama, T, Shigematsu, H, Shirouzu, M, Sekine, S. | | 登録日 | 2017-05-29 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | | 主引用文献 | Structure of the complete elongation complex of RNA polymerase II with basal factors
Science, 357, 2017
|
|
5XXX
 | | GMPCPP-microtubule complexed with nucleotide-free KIF5C | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | 著者 | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | 登録日 | 2017-07-05 | | 公開日 | 2018-10-10 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (6.43 Å) | | 主引用文献 | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
|
|
5XXT
 | | GDP-microtubule complexed with nucleotide-free KIF5C | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | 登録日 | 2017-07-05 | | 公開日 | 2018-10-10 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (5.35 Å) | | 主引用文献 | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
|
|
5XXW
 | | GDP-microtubule complexed with KIF5C in ATP state | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | 登録日 | 2017-07-05 | | 公開日 | 2018-10-10 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (6 Å) | | 主引用文献 | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
|
|
5XXV
 | | GDP-microtubule complexed with KIF5C in AMPPNP state | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | 登録日 | 2017-07-05 | | 公開日 | 2018-10-10 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (6.46 Å) | | 主引用文献 | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
|
|
6TIS
 | | DROSOPHILA GDP-TUBULIN | | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Gigant, B. | | 登録日 | 2019-11-22 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation.
J.Cell Biol., 220, 2021
|
|
6TIZ
 | | DROSOPHILA GDP-TUBULIN Y222F MUTANT | | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Gigant, B. | | 登録日 | 2019-11-22 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation.
J.Cell Biol., 220, 2021
|
|
6TIU
 | | DROSOPHILA GTP-TUBULIN Y222F MUTANT | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Gigant, B. | | 登録日 | 2019-11-22 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.571 Å) | | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation.
J.Cell Biol., 220, 2021
|
|
6TIY
 | | DROSOPHILA GMPCPP-TUBULIN | | 分子名称: | GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Gigant, B. | | 登録日 | 2019-11-22 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.293 Å) | | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation.
J.Cell Biol., 220, 2021
|
|
8JMN
 | | Cryo-EM structure of the gastric proton pump with bound DQ-21 | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[[2-[(4-chlorophenyl)methoxy]phenyl]methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Abe, K, Yokoshima, S, Yoshimori, A. | | 登録日 | 2023-06-05 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (2.26 Å) | | 主引用文献 | Deep learning driven de novo drug design based on gastric proton pump structures.
Commun Biol, 6, 2023
|
|
6LVY
 | | Crystal structure of TLR7/Cpd-2 (SM-360320) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LW0
 | | Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LW1
 | | Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | | 分子名称: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LVZ
 | | Crystal structure of TLR7/Cpd-3 (SM-394830) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LVX
 | | Crystal structure of TLR7/Cpd-1 (SM-374527) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
7C77
 | | Cryo-EM structure of mouse TLR3 in complex with UNC93B1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2020-05-23 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-02-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7C76
 | | Cryo-EM structure of human TLR3 in complex with UNC93B1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2020-05-23 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-02-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7CYN
 | | Cryo-EM structure of human TLR7 in complex with UNC93B1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2020-09-03 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-02-24 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
|
|
5GSZ
 | | Crystal Structure of the KIF19A Motor Domain Complexed with Mg-ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF19, MAGNESIUM ION | | 著者 | Wang, D, Nitta, R, Hirokawa, N. | | 登録日 | 2016-08-18 | | 公開日 | 2016-09-28 | | 最終更新日 | 2020-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
Elife, 5, 2016
|
|
7XMA
 | | Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | | 著者 | Nishida, Y, Shinzawa-Itoh, K, Mizuno, N, Kumasaka, T, Yoshikawa, S, Tsukihara, T, Takashima, S, Shintani, Y. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
|
|
7XMB
 | | Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | | 著者 | Nishida, Y, Shinzawa-Itoh, K, Mizuno, N, Kumasaka, T, Yoshikawa, S, Tsukihara, T, Shintani, Y, Takashima, S. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
|
|
5XOG
 | | RNA Polymerase II elongation complex bound with Spt5 KOW5 and Elf1 | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (30-MER), DNA (39-MER), ... | | 著者 | Ehara, H, Shirouzu, M, Sekine, S. | | 登録日 | 2017-05-28 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of the complete elongation complex of RNA polymerase II with basal factors
Science, 357, 2017
|
|
5HLE
 | |
7VAF
 | |
