7XMB

Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113

Summary for 7XMB

• Entry DOI: 10.2210/pdb7xmb/pdb
• Descriptor: Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 7A1, Cytochrome c oxidase subunit 7B, ... (29 entities in total)
• Functional Keywords: respiratory enzyme, membrane protein, heme protein, allosteric inhibitor, oxidoreductase
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 26
• Total formula weight: 522010.33

Authors

Nishida, Y.,Shinzawa-Itoh, K.,Mizuno, N.,Kumasaka, T.,Yoshikawa, S.,Tsukihara, T.,Shintani, Y.,Takashima, S. (deposition date: 2022-04-25, release date: 2022-12-21, Last modification date: 2023-11-29)

• Primary citation: Nishida, Y.,Yanagisawa, S.,Morita, R.,Shigematsu, H.,Shinzawa-Itoh, K.,Yuki, H.,Ogasawara, S.,Shimuta, K.,Iwamoto, T.,Nakabayashi, C.,Matsumura, W.,Kato, H.,Gopalasingam, C.,Nagao, T.,Qaqorh, T.,Takahashi, Y.,Yamazaki, S.,Kamiya, K.,Harada, R.,Mizuno, N.,Takahashi, H.,Akeda, Y.,Ohnishi, M.,Ishii, Y.,Kumasaka, T.,Murata, T.,Muramoto, K.,Tosha, T.,Shiro, Y.,Honma, T.,Shigeta, Y.,Kubo, M.,Takashima, S.,Shintani, Y.; Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.; Nat Commun, 13:7591-7591, 2022; PubMed: 36481732; DOI: 10.1038/s41467-022-34771-y

Experimental method

X-RAY DIFFRACTION (2.2 Å)