7XMB
Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, N (A, N) | Cytochrome c oxidase subunit 1 | polymer | 514 | 57093.9 | 2 | UniProt (P00396) Pfam (PF00115) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide I |
| 2 | B, O (B, O) | CYTOCHROME C OXIDASE | polymer | 581 | 65935.9 | 2 | Pfam (PF02790) Pfam (PF00116) Pfam (PF00115) UniProt (by SIFTS) (P68530) UniProt (by SIFTS) (P00396) | Bos taurus (cattle) | |
| 3 | C, P (C, P) | Cytochrome c oxidase subunit 3 | polymer | 261 | 29985.6 | 2 | UniProt (P00415) Pfam (PF00510) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide III |
| 4 | D, Q (D, Q) | Cytochrome c oxidase subunit 4 isoform 1 | polymer | 147 | 17179.6 | 2 | UniProt (P00423) Pfam (PF02936) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide IV |
| 5 | E, R (E, R) | Cytochrome c oxidase subunit 5A | polymer | 109 | 12453.1 | 2 | UniProt (P00426) Pfam (PF02284) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide Va |
| 6 | F, S (F, S) | Cytochrome c oxidase subunit 5B, mitochondrial | polymer | 98 | 10684.0 | 2 | UniProt (P00428) Pfam (PF01215) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VIa,Cytochrome c oxidase polypeptide Vb |
| 7 | G, T (G, T) | Cytochrome c oxidase subunit 6A2, mitochondrial | polymer | 84 | 9532.7 | 2 | UniProt (P07471) Pfam (PF02046) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VIa-heart,COXVIAH,Cytochrome c oxidase polypeptide VIb |
| 8 | H, U (H, U) | Cytochrome c oxidase subunit 6B1 | polymer | 85 | 10039.2 | 2 | UniProt (P00429) Pfam (PF02297) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VII |
| 9 | I, V (I, V) | Cytochrome c oxidase subunit 6C | polymer | 73 | 8495.0 | 2 | UniProt (P04038) Pfam (PF02937) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VIc,Cytochrome c oxidase subunit STA |
| 10 | J, W (J, W) | Cytochrome c oxidase subunit 7A1 | polymer | 59 | 6682.7 | 2 | UniProt (P07470) Pfam (PF02238) | Bos taurus (cattle) | Cytochrome c oxidase subunit VIIIc,VIIIC |
| 11 | K, X (K, X) | Cytochrome c oxidase subunit 7B | polymer | 56 | 6365.2 | 2 | UniProt (P13183) Pfam (PF05392) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VIIb |
| 12 | L, Y (L, Y) | Cytochrome c oxidase subunit 7C, mitochondrial | polymer | 47 | 5449.4 | 2 | UniProt (P00430) Pfam (PF02935) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VIIIA |
| 13 | M, Z (M, Z) | Cytochrome c oxidase subunit 8B | polymer | 46 | 4967.8 | 2 | UniProt (P10175) Pfam (PF02285) | Bos taurus (cattle) | Cytochrome c oxidase polypeptide VIII-heart |
| 14 | AA, BA, CB, DB (A, N) | HEME-A | non-polymer | 852.8 | 4 | Chemie (HEA) | |||
| 15 | CA, EB (A, N) | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) PubChem (27099) | |||
| 16 | DA, FB (A, N) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 17 | EA, GB (A, N) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 18 | FA, HB (A, N) | PEROXIDE ION | non-polymer | 32.0 | 2 | Chemie (PER) | |||
| 19 | AB, AC, GA, JB, WA... (L, Y, A, N, D...) | TRISTEAROYLGLYCEROL | non-polymer | 891.5 | 6 | Chemie (TGL) PubChem (11146) | |||
| 20 | HA, MB (A, N) | 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol | non-polymer | 247.3 | 2 | Chemie (J6X) PubChem (2821748) | |||
| 21 | IA, NB (B, O) | DINUCLEAR COPPER ION | non-polymer | 127.1 | 2 | Chemie (CUA) | |||
| 22 | JA, KB, OB, PA, QA... (B, N, O, C, P) | CHOLIC ACID | non-polymer | 408.6 | 6 | Chemie (CHD) PubChem (16401672) PubChem (16758100) PubChem (18528842) PubChem (20638765) PubChem (303) PubChem (23636694) PubChem (23640631) PubChem (6676) PubChem (23876184) PubChem (24836753) PubChem (24883735) PubChem (43835083) PubChem (16401251) PubChem (44135469) PubChem (44629918) PubChem (44657327) PubChem (21139644) PubChem (45114537) PubChem (45382168) PubChem (122340) PubChem (1762378) PubChem (46397523) PubChem (46783697) PubChem (49791911) PubChem (49796810) PubChem (50989873) PubChem (51432410) PubChem (51546373) PubChem (53298695) PubChem (53393606) PubChem (53477699) PubChem (160636) PubChem (221493) PubChem (57937243) PubChem (44339334) PubChem (58133002) PubChem (58582306) PubChem (376829) PubChem (439520) PubChem (58984417) PubChem (59032051) PubChem (59316662) PubChem (59877711) PubChem (59963674) PubChem (59997751) PubChem (60076012) PubChem (60098994) PubChem (60114995) PubChem (440427) PubChem (46780112) PubChem (66678354) PubChem (68097396) PubChem (68131418) PubChem (68318251) PubChem (68338620) PubChem (68372213) PubChem (71260265) PubChem (70649328) PubChem (70824975) PubChem (70930320) PubChem (70930789) PubChem (70960845) PubChem (637625) PubChem (59130005) PubChem (59381614) PubChem (59903914) PubChem (67122255) PubChem (3246132) PubChem (69904012) PubChem (130213) PubChem (145883) PubChem (70866085) PubChem (71001249) PubChem (239672) PubChem (71314856) PubChem (71752895) PubChem (5283869) PubChem (5283870) PubChem (5283871) PubChem (5283873) PubChem (5283875) PubChem (5283877) PubChem (5283878) PubChem (74765127) PubChem (89830646) PubChem (5302608) PubChem (5315844) PubChem (91128541) PubChem (91810856) PubChem (5283876) PubChem (5283879) PubChem (5283880) PubChem (5283872) PubChem (5283874) PubChem (98044963) PubChem (99565617) PubChem (122645815) PubChem (124161889) PubChem (124318072) PubChem (124488681) PubChem (125037036) PubChem (126577457) PubChem (129274856) PubChem (129274855) PubChem (129359810) PubChem (6708709) PubChem (6850901) PubChem (6850905) PubChem (99564899) PubChem (99565857) PubChem (133135020) PubChem (133126746) PubChem (11350342) PubChem (117684834) PubChem (117767695) PubChem (117944573) PubChem (118241311) PubChem (9802771) PubChem (121232934) PubChem (9846429) PubChem (9866174) PubChem (122537896) PubChem (122537897) PubChem (122644681) PubChem (122644923) PubChem (122646384) PubChem (12303168) PubChem (13020196) PubChem (71172094) PubChem (124328806) PubChem (124364505) PubChem (124425250) PubChem (124488680) PubChem (124511215) PubChem (124518077) PubChem (124518078) PubChem (124518446) PubChem (124761950) PubChem (12080557) PubChem (12303167) PubChem (12303172) PubChem (12303175) PubChem (12303178) PubChem (12303180) PubChem (13020205) PubChem (124841930) PubChem (124896923) PubChem (124896924) PubChem (124896925) PubChem (124896926) PubChem (124904187) PubChem (124904188) PubChem (124906682) PubChem (124906683) PubChem (124914603) PubChem (124914604) PubChem (124914605) PubChem (124914606) PubChem (125027431) PubChem (125037037) PubChem (162771689) PubChem (163059393) PubChem (163059399) PubChem (163059389) PubChem (126422551) PubChem (126422552) PubChem (126577461) PubChem (126672319) PubChem (166858402) PubChem (126969154) PubChem (129106816) PubChem (129460958) PubChem (129600748) PubChem (129628082) PubChem (130220803) PubChem (131700165) PubChem (132441695) PubChem (133548348) PubChem (133612061) PubChem (133655733) PubChem (133687870) PubChem (133688934) PubChem (134462403) PubChem (134555902) PubChem (134866321) PubChem (135373095) PubChem (137474142) PubChem (138107312) PubChem (139248576) PubChem (139291795) PubChem (139372812) PubChem (140618124) PubChem (141854542) PubChem (142134118) PubChem (143658950) PubChem (144316980) PubChem (145264188) PubChem (145714625) PubChem (146030145) PubChem (146665897) PubChem (154033190) PubChem (154036252) PubChem (154747009) PubChem (154825357) PubChem (155275443) PubChem (155605940) PubChem (157048615) PubChem (157269375) PubChem (157351909) PubChem (157383333) PubChem (158041002) PubChem (158420924) PubChem (158675416) PubChem (160081178) PubChem (160743345) PubChem (160917187) PubChem (161973449) PubChem (163059390) PubChem (163059391) PubChem (163059392) PubChem (163059394) PubChem (163059395) PubChem (163059396) PubChem (163059397) PubChem (163059398) PubChem (163059400) PubChem (163452349) PubChem (163452350) PubChem (163452351) PubChem (167344826) PubChem (168841979) PubChem (168841990) PubChem (168845540) PubChem (169410142) PubChem (169436432) PubChem (171721516) PubChem (157060709) | |||
| 23 | KA, PB (B, O) | (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE | non-polymer | 759.1 | 2 | Chemie (PSC) PubChem (122219) PubChem (46936343) PubChem (53962049) PubChem (446962) PubChem (5313189) PubChem (5313191) PubChem (5289212) PubChem (5313188) PubChem (5313190) PubChem (124586127) | |||
| 24 | LA, QB, RA, UA, VB... (B, P, C, G) | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE | non-polymer | 768.1 | 6 | Chemie (PEK) PubChem (21158855) PubChem (44552596) PubChem (45253969) PubChem (45253978) PubChem (53301835) PubChem (72280040) PubChem (53652586) PubChem (73659094) PubChem (5289133) PubChem (123132887) PubChem (9546819) PubChem (6426736) PubChem (134812608) PubChem (9546829) PubChem (9546830) PubChem (145998242) PubChem (156613384) PubChem (162679672) | |||
| 25 | IB, LB, MA, NA, RB... (N, C, P, D) | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE | non-polymer | 749.0 | 8 | Chemie (PGV) PubChem (21158857) PubChem (73746220) PubChem (5289145) PubChem (162368821) PubChem (163029036) | |||
| 26 | OA, TB, YB, ZA (C, P, T, G) | CARDIOLIPIN | non-polymer | 1464.0 | 4 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 27 | BB, BC, TA, ZB (M, Z, C, W) | DECYL-BETA-D-MALTOPYRANOSIDE | non-polymer | 482.6 | 4 | Chemie (DMU) PubChem (24776995) PubChem (16396531) PubChem (45253991) PubChem (45254001) PubChem (24802064) PubChem (56845266) PubChem (58112552) PubChem (45253971) PubChem (59518661) PubChem (49866911) PubChem (70796430) PubChem (70839938) PubChem (71307274) PubChem (3637526) PubChem (5288091) PubChem (95370473) PubChem (98046563) PubChem (5288728) PubChem (101207920) PubChem (126735852) PubChem (95370474) PubChem (95370475) PubChem (95370476) PubChem (98046559) PubChem (98046561) PubChem (100941450) PubChem (100950626) PubChem (102219024) PubChem (118704896) PubChem (123134571) PubChem (124867949) PubChem (124867950) PubChem (124867951) PubChem (124867952) PubChem (126731012) PubChem (126731036) PubChem (126735974) PubChem (168490163) | |||
| 28 | XA, XB (F, S) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 29 | AD, BD, CC, DC, EC... (Y, Z, A, B, C...) | water | water | 18.0 | 2495 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 26 |
| Total formula weight | 489728.4 | |
| Non-Polymers* | Number of molecules | 54 |
| Total formula weight | 32281.9 | |
| All* | Total formula weight | 522010.3 |
