1DMB
 
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1MDQ
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1OMP
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1MDP
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6CDS
 | | Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ... | | 著者 | Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T. | | 登録日 | 2018-02-09 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
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1EK9
 | | 2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI | | 分子名称: | OUTER MEMBRANE PROTEIN TOLC | | 著者 | Koronakis, V, Sharff, A.J, Koronakis, E, Luisi, B, Hughes, C. | | 登録日 | 2000-03-07 | | 公開日 | 2000-06-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature, 405, 2000
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3U8Z
 | | human merlin FERM domain | | 分子名称: | Merlin | | 著者 | Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T. | | 登録日 | 2011-10-17 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Protein Sci., 20, 2011
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3P39
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3P38
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2Q11
 | | Structure of BACE complexed to compound 1 | | 分子名称: | 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE, Beta-secretase 1 | | 著者 | Sharff, A.J. | | 登録日 | 2007-05-23 | | 公開日 | 2007-08-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
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2Q15
 | | Structure of BACE complexed to compound 3a | | 分子名称: | (4S)-4-(2-AMINO-6-PHENOXYQUINAZOLIN-3(4H)-YL)-N,4-DICYCLOHEXYL-N-METHYLBUTANAMIDE, Beta-secretase 1 | | 著者 | Sharff, A.J. | | 登録日 | 2007-05-23 | | 公開日 | 2007-08-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
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1ANF
 | | MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTOSE | | 分子名称: | MALTODEXTRIN-BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Spurlino, J.C, Quiocho, F.A. | | 登録日 | 1997-06-25 | | 公開日 | 1997-12-24 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
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2XQY
 | | CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A13-D6.3 MONOCLONAL ANTIBODY, ... | | 著者 | Backovic, M, Dubois, R, Cockburn, J, Sharff, A, Vaney, M, Granzow, H, Klupp, B, Bricogne, G, Mettenleiter, T, Rey, F. | | 登録日 | 2010-09-08 | | 公開日 | 2010-12-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of a Core Fragment of Glycoprotein H from Pseudorabies Virus in Complex with Antibody.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4MBP
 | | MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTETROSE | | 分子名称: | MALTODEXTRIN BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Spurlino, J.C, Quiocho, F.A. | | 登録日 | 1997-08-17 | | 公開日 | 1998-02-25 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
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3MBP
 | | MALTODEXTRIN-BINDING PROTEIN WITH BOUND MALTOTRIOSE | | 分子名称: | MALTODEXTRIN-BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Spurlino, J.C, Quiocho, F.A. | | 登録日 | 1997-06-25 | | 公開日 | 1997-12-24 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
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2ADA
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1A4M
 | | ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0 | | 分子名称: | 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION | | 著者 | Wang, Z, Quiocho, F.A. | | 登録日 | 1998-01-31 | | 公開日 | 1998-10-14 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
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1A4L
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1LLS
 | | CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON | | 分子名称: | Maltose-binding periplasmic protein, XENON | | 著者 | Rubin, S.M, Lee, S.-Y, Ruiz, E.J, Pines, A, Wemmer, D.E. | | 登録日 | 2002-04-30 | | 公開日 | 2002-09-18 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | DETECTION AND CHARACTERIZATION OF XENON-BINDING SITES IN PROTEINS BY 129XE NMR SPECTROSCOPY
J.MOL.BIOL., 322, 2002
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