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PDB: 11 results
1DMB
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BU of 1dmb by Molmil
REFINED 1.8 ANGSTROMS STRUCTURE REVEALS THE MECHANISM OF BINDING OF A CYCLIC SUGAR, BETA-CYCLODEXTRIN, TO THE MALTODEXTRIN BINDING PROTEIN
Descriptor: Cycloheptakis-(1-4)-(alpha-D-glucopyranose), D-MALTODEXTRIN BINDING PROTEIN
Authors:Sharff, A.J, Quiocho, F.A.
Deposit date:1993-06-10
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Refined 1.8-A structure reveals the mode of binding of beta-cyclodextrin to the maltodextrin binding protein.
Biochemistry, 32, 1993
1MDQ
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BU of 1mdq by Molmil
REFINED STRUCTURES OF TWO INSERTION(SLASH)DELETION MUTANTS PROBE FUNCTION OF THE MALTODEXTRIN BINDING PROTEIN
Descriptor: MALTODEXTRIN BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Sharff, A.J, Quiocho, F.A.
Deposit date:1994-08-10
Release date:1994-11-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of two insertion/deletion mutants probe function of the maltodextrin binding protein.
J.Mol.Biol., 246, 1995
1OMP
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BU of 1omp by Molmil
CRYSTALLOGRAPHIC EVIDENCE OF A LARGE LIGAND-INDUCED HINGE-TWIST MOTION BETWEEN THE TWO DOMAINS OF THE MALTODEXTRIN-BINDING PROTEIN INVOLVED IN ACTIVE TRANSPORT AND CHEMOTAXIS
Descriptor: D-MALTODEXTRIN BINDING PROTEIN
Authors:Sharff, A.J, Quiocho, F.A.
Deposit date:1992-09-14
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis.
Biochemistry, 31, 1992
1MDP
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BU of 1mdp by Molmil
REFINED STRUCTURES OF TWO INSERTION(SLASH)DELETION MUTANTS PROBE FUNCTION OF THE MALTODEXTRIN BINDING PROTEIN
Descriptor: MALTODEXTRIN BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Sharff, A.J, Quiocho, F.A.
Deposit date:1994-08-10
Release date:1994-11-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined structures of two insertion/deletion mutants probe function of the maltodextrin binding protein.
J.Mol.Biol., 246, 1995
2Q11
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BU of 2q11 by Molmil
Structure of BACE complexed to compound 1
Descriptor: 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE, Beta-secretase 1
Authors:Sharff, A.J.
Deposit date:2007-05-23
Release date:2007-08-14
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
2Q15
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BU of 2q15 by Molmil
Structure of BACE complexed to compound 3a
Descriptor: (4S)-4-(2-AMINO-6-PHENOXYQUINAZOLIN-3(4H)-YL)-N,4-DICYCLOHEXYL-N-METHYLBUTANAMIDE, Beta-secretase 1
Authors:Sharff, A.J.
Deposit date:2007-05-23
Release date:2007-08-14
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
6CDS
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BU of 6cds by Molmil
Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ...
Authors:Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T.
Deposit date:2018-02-09
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
1EK9
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BU of 1ek9 by Molmil
2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI
Descriptor: OUTER MEMBRANE PROTEIN TOLC
Authors:Koronakis, V, Sharff, A.J, Koronakis, E, Luisi, B, Hughes, C.
Deposit date:2000-03-07
Release date:2000-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature, 405, 2000
3U8Z
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BU of 3u8z by Molmil
human merlin FERM domain
Descriptor: Merlin
Authors:Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T.
Deposit date:2011-10-17
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Protein Sci., 20, 2011
3P39
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BU of 3p39 by Molmil
Crystal structure of the NS1 effector domain W182A mutant from influenza A/Vietnam/1203/2004 (H5N1) virus
Descriptor: Nonstructural protein 1
Authors:Chen, S, Xiao, Y.B, Bricogne, G, Sharff, A.J, Hilgenfeld, R.
Deposit date:2010-10-04
Release date:2011-10-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:X-ray structures of the NS1 effector domain from highly pathogenic influenza A/Vietnam/1203/2004 (H5N1) virus
To be Published
3P38
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BU of 3p38 by Molmil
Crystal structure of the NS1 effector domain W182A mutant from influenza A/Vietnam/1203/2004 (H5N1) virus
Descriptor: Nonstructural protein 1
Authors:Chen, S, Xiao, Y.B, Bricogne, G, Sharff, A.J, Hilgenfeld, R.
Deposit date:2010-10-04
Release date:2011-10-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:X-ray structures of the NS1 effector domain from highly pathogenic influenza A/Vietnam/1203/2004 (H5N1) virus
To be Published

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