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4XT2
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BU of 4xt2 by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
分子名称: (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Scheuermann, T.H, Gardner, K.H.
登録日2015-01-22
公開日2015-12-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.
J.Med.Chem., 58, 2015
1PJZ
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BU of 1pjz by Molmil
Solution structure of thiopurine methyltransferase from Pseudomonas syringae
分子名称: Thiopurine S-methyltransferase
著者Scheuermann, T.H, Lolis, E, Hodsdon, M.E.
登録日2003-06-04
公開日2003-10-14
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme
J.Mol.Biol., 333, 2003
4GHI
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BU of 4ghi by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a benzoxadiazole antagonist
分子名称: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
著者Scheuermann, T.H, Key, J, Tambar, U.K, Bruick, R.K, Gardner, K.H.
登録日2012-08-07
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Nat.Chem.Biol., 9, 2013
3F1P
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BU of 3f1p by Molmil
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains
分子名称: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
登録日2008-10-28
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F1O
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BU of 3f1o by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with an internally-bound artificial ligand
分子名称: 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ...
著者Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
登録日2008-10-28
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F1N
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BU of 3f1n by Molmil
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol.
分子名称: 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
登録日2008-10-28
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.479 Å)
主引用文献Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
4GS9
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BU of 4gs9 by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist
分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ...
著者Scheuermann, T.H, Gardner, K.H.
登録日2012-08-27
公開日2013-04-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor
J.Med.Chem., 56, 2013
4LPZ
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BU of 4lpz by Molmil
ARNT transcription factor/coactivator complex
分子名称: Aryl hydrocarbon receptor nuclear translocator, Transforming acidic coiled-coil-containing protein 3
著者Guo, Y, Scheuermann, T.H, Gardner, K.H.
登録日2013-07-16
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.
J.Biol.Chem., 290, 2015
3H7W
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BU of 3h7w by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017
分子名称: 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Key, J.M, Scheuermann, T.H, Anderson, P.C, Daggett, V, Gardner, K.H.
登録日2009-04-28
公開日2010-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
J.Am.Chem.Soc., 131, 2009
3H82
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BU of 3h82 by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS020
分子名称: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(furan-2-ylmethyl)-2-nitro-4-(trifluoromethyl)aniline
著者Key, J.M, Scheuermann, T.H, Anderson, P.C, Daggett, V, Gardner, K.H.
登録日2009-04-28
公開日2010-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
J.Am.Chem.Soc., 131, 2009
4PKY
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BU of 4pky by Molmil
ARNT/HIF transcription factor/coactivator complex
分子名称: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, SULFATE ION, ...
著者Tomchick, D.R, Partch, C.L, Gardner, K.H.
登録日2014-05-15
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization.
J.Biol.Chem., 290, 2015
4ZJC
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BU of 4zjc by Molmil
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
分子名称: OLEIC ACID, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, human OX1R fusion protein to P.abysii glycogen synthase
著者Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P.J, Renger, J.J, Rosenbaum, D.M.
登録日2015-04-29
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.832 Å)
主引用文献Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
4ZJ8
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BU of 4zj8 by Molmil
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
分子名称: OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, human OX1R fusion protein to P.abysii glycogen synthase
著者Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P, Renger, J.J, Rosenbaum, D.M.
登録日2015-04-29
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.751 Å)
主引用文献Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016

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