7RHQ
| Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Huang, P, Lian, T, Wierbowski, B, Garcia-Linares, S, Jiang, J, Salic, A. | 登録日 | 2021-07-18 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev.Cell, 57, 2022
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7RHR
| Cryo-EM structure of Xenopus Patched-1 in nanodisc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Huang, P, Lian, T, Jiang, J, Salic, A. | 登録日 | 2021-07-18 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev.Cell, 57, 2022
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6D35
| Crystal structure of Xenopus Smoothened in complex with cholesterol | 分子名称: | CHOLESTEROL, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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6D32
| Crystal structure of Xenopus Smoothened in complex with cyclopamine | 分子名称: | Cyclopamine, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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5KZV
| Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with 20(S)-hydroxycholesterol | 分子名称: | (3alpha,8alpha)-cholest-5-ene-3,20-diol, Smoothened | 著者 | Huang, P, Kim, Y, Salic, A. | 登録日 | 2016-07-25 | 公開日 | 2016-08-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.616 Å) | 主引用文献 | Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell, 166, 2016
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5KZY
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5KZZ
| Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in its apo-form | 分子名称: | ACETATE ION, GLYCEROL, Smoothened, ... | 著者 | Huang, P, Kim, Y, Salic, A. | 登録日 | 2016-07-25 | 公開日 | 2016-08-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.332 Å) | 主引用文献 | Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell, 166, 2016
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7E2G
| Cryo-EM structure of hDisp1NNN-3C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1,Protein dispatched homolog 1 | 著者 | Li, W, Wang, L, Gong, X. | 登録日 | 2021-02-05 | 公開日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun, 12, 2021
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7E2I
| Cryo-EM structure of hDisp1NNN-ShhN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1, ... | 著者 | Li, W, Wang, L, Gong, X. | 登録日 | 2021-02-05 | 公開日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | 主引用文献 | Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun, 12, 2021
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7E2H
| Cryo-EM structure of hDisp1NNN-3C-Cleavage | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1 | 著者 | Li, W, Wang, L, Gong, X. | 登録日 | 2021-02-05 | 公開日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun, 12, 2021
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