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3ZVM
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BU of 3zvm by Molmil
The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*GP*TP*CP*AP*CP)-3', ACETATE ION, ...
Authors:Garces, F, Pearl, L.H, Oliver, A.W.
Deposit date:2011-07-25
Release date:2011-11-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Mol. Cell, 44, 2011
4BU1
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BU of 4bu1 by Molmil
Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide
Descriptor: 1,2-ETHANEDIOL, DNA REPAIR PROTEIN RHP9, GLYCEROL, ...
Authors:Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H.
Deposit date:2013-06-19
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.).
Mol.Cell, 51, 2013
4BMC
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BU of 4bmc by Molmil
Crystal structure of s.pombe Rad4 BRCT1,2
Descriptor: CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4
Authors:Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H.
Deposit date:2013-05-07
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.).
Mol.Cell, 51, 2013
4BMD
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BU of 4bmd by Molmil
Crystal structure of S.pombe Rad4 BRCT3,4
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4
Authors:Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H.
Deposit date:2013-05-07
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.).
Mol.Cell, 51, 2013
3ZVN
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BU of 3zvn by Molmil
The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase
Descriptor: 5'-D(*GP*TP*CP*AP*CP)-3', ADENOSINE-5'-DIPHOSPHATE, BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, ...
Authors:Garces, F, Pearl, L.H, Oliver, A.W.
Deposit date:2011-07-25
Release date:2011-11-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Mol. Cell, 44, 2011
4BU0
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BU of 4bu0 by Molmil
Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide
Descriptor: ACETATE ION, DNA REPAIR PROTEIN RHP9, GLYCEROL, ...
Authors:Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H.
Deposit date:2013-06-19
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.).
Mol.Cell, 51, 2013
1GEC
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BU of 1gec by Molmil
GLYCYL ENDOPEPTIDASE-COMPLEX WITH BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE COVALENTLY BOUND TO CYSTEINE 25
Descriptor: BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE INHIBITOR, GLYCYL ENDOPEPTIDASE
Authors:Ohara, B.P, Hemmings, A.M, Buttle, D.J, Pearl, L.H.
Deposit date:1995-05-25
Release date:1995-12-07
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of glycyl endopeptidase from Carica papaya: a cysteine endopeptidase of unusual substrate specificity.
Biochemistry, 34, 1995
1GML
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BU of 1gml by Molmil
crystal structure of the mouse CCT gamma apical domain (triclinic)
Descriptor: GLYCEROL, T-COMPLEX PROTEIN 1 SUBUNIT GAMMA
Authors:Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H.
Deposit date:2001-09-17
Release date:2002-06-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1GN1
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BU of 1gn1 by Molmil
crystal structure of the mouse CCT gamma apical domain (monoclinic)
Descriptor: CALCIUM ION, CCT-GAMMA
Authors:Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H.
Deposit date:2001-10-01
Release date:2002-06-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1H0C
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BU of 1h0c by Molmil
The crystal structure of human alanine:glyoxylate aminotransferase
Descriptor: (AMINOOXY)ACETIC ACID, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Zhang, X, Danpure, C.J, Roe, S.M, Pearl, L.H.
Deposit date:2002-06-17
Release date:2003-06-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1.
J.Mol.Biol., 331, 2003
1BGQ
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BU of 1bgq by Molmil
RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor: HEAT SHOCK PROTEIN 90, RADICICOL
Authors:Roe, S.M, Prodromou, C, Pearl, L.H.
Deposit date:1998-05-29
Release date:1999-06-08
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
J.Med.Chem., 42, 1999
1AH6
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BU of 1ah6 by Molmil
STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor: HEAT SHOCK PROTEIN 90
Authors:Prodromou, C, Roe, S.M, Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1AH8
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BU of 1ah8 by Molmil
STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor: GLYCEROL, HEAT SHOCK PROTEIN 90
Authors:Prodromou, C, Roe, S.M, Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1HK7
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BU of 1hk7 by Molmil
Middle Domain of HSP90
Descriptor: CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION
Authors:Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H.
Deposit date:2003-03-06
Release date:2004-01-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
1KCF
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BU of 1kcf by Molmil
Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2
Descriptor: HYPOTHETICAL 30.2 KD PROTEIN C25G10.02 IN CHROMOSOME I, SULFATE ION
Authors:Ceschini, S, Keeley, A, McAlister, M.S.B, Oram, M, Phelan, J, Pearl, L.H, Tsaneva, I.R, Barrett, T.E.
Deposit date:2001-11-08
Release date:2001-11-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2.
EMBO J., 20, 2001
1KO9
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BU of 1ko9 by Molmil
Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1
Descriptor: 8-oxoguanine DNA glycosylase, SULFATE ION
Authors:Bjoras, M, Seeberg, E, Luna, L, Pearl, L.H, Barrett, T.E.
Deposit date:2001-12-20
Release date:2002-01-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase.
J.Mol.Biol., 317, 2002
1A4H
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BU of 1a4h by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
Descriptor: GELDANAMYCIN, HEAT SHOCK PROTEIN 90
Authors:Prodromou, C, Roe, S.M, Pearl, L.H.
Deposit date:1998-01-29
Release date:1998-08-05
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
7AUD
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BU of 7aud by Molmil
Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Bloom syndrome protein,Bloom syndrome protein, DNA (5'-D(*GP*TP*AP*CP*CP*CP*GP*AP*TP*GP*TP*GP*T)-3'), ...
Authors:Chen, X, Oliver, A.W.
Deposit date:2020-11-02
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Elife, 10, 2021
7AUC
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BU of 7auc by Molmil
Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Chen, X, Oliver, A.W.
Deposit date:2020-11-02
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Elife, 10, 2021
4ER4
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BU of 4er4 by Molmil
HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES
Descriptor: ENDOTHIAPEPSIN, H-142
Authors:Foundling, S.I, Watson, F.E, Szelke, M, Blundell, T.L.
Deposit date:1991-01-05
Release date:1991-04-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature, 327, 1987
7OLE
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BU of 7ole by Molmil
Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2, ...
Authors:Pal, M, Llorca, O, Pearl, L.
Deposit date:2021-05-19
Release date:2021-07-07
Last modified:2021-10-06
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.
Cell Rep, 36, 2021
5MGX
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BU of 5mgx by Molmil
The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP8, yeast HSP90 C-terminus
Authors:Roe, S.M, Blundell, K.L, Prodromou, C.
Deposit date:2016-11-22
Release date:2017-03-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.
PLoS ONE, 12, 2017
4CV4
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BU of 4cv4 by Molmil
PIH N-terminal domain
Descriptor: COBALT (II) ION, PIH1 DOMAIN-CONTAINING PROTEIN 1, SULFATE ION
Authors:Morgan, R.M, Roe, S.M.
Deposit date:2014-03-23
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.
Structure, 22, 2014
4CSE
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BU of 4cse by Molmil
PIH N-terminal domain
Descriptor: PIH1 DOMAIN-CONTAINING PROTEIN 1, TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG
Authors:Morgan, R.M, Roe, S.M.
Deposit date:2014-03-07
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.
Structure, 22, 2014
4U6A
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BU of 4u6a by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one, GLYCEROL, ...
Authors:Oliver, A.W.
Deposit date:2014-07-28
Release date:2015-07-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors
To be published

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