4JT5
 
 | | mTORdeltaN-mLST8-pp242 complex | | Descriptor: | 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | | Authors: | Pavletich, N.P, Yang, H. | | Deposit date: | 2013-03-22 | | Release date: | 2013-05-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
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4JSX
 | | structure of mTORDeltaN-mLST8-Torin2 complex | | Descriptor: | 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | | Authors: | Pavletich, N.P, Yang, H. | | Deposit date: | 2013-03-22 | | Release date: | 2013-05-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
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5WBL
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5WBH
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5WBK
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5WBI
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5WBU
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5WBJ
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5WBY
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3CMX
 | | Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DTP*DT)-3'), ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2008-03-24 | | Release date: | 2008-05-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Nature, 453, 2008
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3CMW
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3CMV
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3CMU
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7JY9
 | | Structure of a 9 base pair RecA-D loop complex | | Descriptor: | DNA (27-MER), DNA (42-MER), MAGNESIUM ION, ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2020-08-29 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.
Nature, 586, 2020
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7JY6
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7JY8
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7JY7
 | | Structure of a 12 base pair RecA-D loop complex | | Descriptor: | DNA (27-MER), DNA (48-MER), MAGNESIUM ION, ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2020-08-29 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.
Nature, 586, 2020
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1IYJ
 | | STRUCTURE OF A BRCA2-DSS1 COMPLEX | | Descriptor: | Deleted in split hand/split foot protein 1, breast cancer susceptibility | | Authors: | Pavletich, N.P, Jeffrey, P.D, Yang, H.J. | | Deposit date: | 2002-08-28 | | Release date: | 2002-10-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
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1J8F
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3O4Z
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7SIC
 | | Human ATM Dimer | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM | | Authors: | Warren, C, Pavletich, N.P. | | Deposit date: | 2021-10-13 | | Release date: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (2.51 Å) | | Cite: | Structure of the human ATM kinase and mechanism of Nbs1 binding.
Elife, 11, 2022
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7SID
 | | Human ATM Dimer Bound to Nbs1 | | Descriptor: | MAGNESIUM ION, Nibrin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Warren, C, Pavletich, N.P. | | Deposit date: | 2021-10-13 | | Release date: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Structure of the human ATM kinase and mechanism of Nbs1 binding.
Elife, 11, 2022
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1OZJ
 | | Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution | | Descriptor: | SMAD 3, Smad binding element, ZINC ION | | Authors: | Chai, J, Wu, J.-W, Yan, N, Massague, J, Pavletich, N.P, Shi, Y. | | Deposit date: | 2003-04-09 | | Release date: | 2004-03-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.
J.Biol.Chem., 278, 2003
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1P22
 | | Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase | | Descriptor: | Beta-catenin, F-box/WD-repeat protein 1A, Skp1 | | Authors: | Wu, G, Xu, G, Schulman, B.A, Jeffrey, P.D, Harper, J.W, Pavletich, N.P. | | Deposit date: | 2003-04-14 | | Release date: | 2003-07-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase
Mol.Cell, 11, 2003
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1PI1
 | | Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways. | | Descriptor: | Mob1A, ZINC ION | | Authors: | Stavridi, E.S, Harris, K.G, Huyen, Y, Bothos, J, Voewerd, P.M, Stayrook, S.E, Jeffrey, P.D, Pavletich, N.P, Luca, F.C. | | Deposit date: | 2003-05-29 | | Release date: | 2003-09-30 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a human mob1 protein. Toward understanding mob-regulated cell cycle pathways.
Structure, 11, 2003
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