7LH7
| Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor | 分子名称: | Bcl-2-like protein 1, N-(1,3-benzothiazol-2-yl)-2-(4-{[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]carbamoyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide | 著者 | Judge, R.A, Tao, Z. | 登録日 | 2021-01-21 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.409 Å) | 主引用文献 | Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor ACS Medicinal Chemistry Letters, 12, 2021
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8HEK
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8JB3
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8J6H
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6L5K
| ARF5 Aux/IAA17 Complex | 分子名称: | Auxin response factor 5, Auxin-responsive protein IAA17 | 著者 | Ryu, K.S, Suh, J.Y, Cha, S.Y, Kim, Y.I, Park, C.K. | 登録日 | 2019-10-24 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17. J.Mol.Biol., 432, 2020
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6B4U
| Crystal structure of MCL-1 in complex with a BIM competitive inhibitor | 分子名称: | 7-(2-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Judge, R.A, Souers, A.J. | 登録日 | 2017-09-27 | 公開日 | 2017-10-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J. Med. Chem., 58, 2015
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6B4L
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7WCG
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4Z7P
| X-ray structure of racemic ShK Q16K toxin | 分子名称: | Potassium channel toxin kappa-stichotoxin-She1a, SULFATE ION | 著者 | Sickmier, E.A. | 登録日 | 2015-04-07 | 公開日 | 2015-09-09 | 最終更新日 | 2015-09-23 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J.Med.Chem., 58, 2015
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4N8M
| Structural polymorphism in the N-terminal oligomerization domain of NPM1 | 分子名称: | COBALT (II) ION, Nucleophosmin | 著者 | Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W. | 登録日 | 2013-10-17 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc.Natl.Acad.Sci.USA, 111, 2014
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2AYP
| Crystal Structure of CHK1 with an Indol Inhibitor | 分子名称: | (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE, Serine/threonine-protein kinase Chk1 | 著者 | Lin, N.-H, Xia, P, Kovar, P, Chen, Z, Zhang, H, Rosenberg, S.H, Sham, H.L. | 登録日 | 2005-09-07 | 公開日 | 2006-09-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors Bioorg.Med.Chem.Lett., 16, 2006
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2KAL
| NMR structure of fully methylated GATC site | 分子名称: | 5'-D(*DCP*DGP*DCP*DAP*DGP*(6MA)P*DTP*DCP*DTP*DCP*DGP*DC)-3', 5'-D(*DGP*DCP*DGP*DAP*DGP*(6MA)P*DTP*DCP*DTP*DGP*DCP*DG)-3' | 著者 | Bang, J, Bae, S, Park, C, Lee, J, Choi, B. | 登録日 | 2008-11-09 | 公開日 | 2009-02-10 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and dynamics study of DNA dodecamer duplexes that contain un-, hemi-, or fully methylated GATC sites. J.Am.Chem.Soc., 130, 2008
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2LBW
| Solution structure of the S. cerevisiae H/ACA RNP protein Nhp2p-S82W mutant | 分子名称: | H/ACA ribonucleoprotein complex subunit 2 | 著者 | Koo, B, Park, C, Fernandez, C.F, Chim, N, Ding, Y, Chanfreau, G, Feigon, J. | 登録日 | 2011-04-07 | 公開日 | 2011-07-06 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface. J.Mol.Biol., 411, 2011
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2LBX
| Solution structure of the S. cerevisiae H/ACA RNP protein Nhp2p | 分子名称: | H/ACA ribonucleoprotein complex subunit 2 | 著者 | Koo, B, Park, C, Fernandez, C.F, Chim, N, Ding, Y, Chanfreau, G, Feigon, J. | 登録日 | 2011-04-07 | 公開日 | 2011-07-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface. J.Mol.Biol., 411, 2011
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3MA0
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3M9X
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3M9W
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1IZZ
| Crystal structure of Hsp31 | 分子名称: | Hsp31 | 著者 | Cha, S.S, Lee, S.J. | 登録日 | 2002-10-16 | 公開日 | 2003-10-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain J.Biol.Chem., 278, 2003
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1IZY
| Crystal structure of Hsp31 | 分子名称: | Hsp31 | 著者 | Cha, S.S, Lee, S.J. | 登録日 | 2002-10-16 | 公開日 | 2003-10-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain J.Biol.Chem., 278, 2003
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1J42
| Crystal Structure of Human DJ-1 | 分子名称: | RNA-binding protein regulatory subunit | 著者 | Cha, S.S. | 登録日 | 2003-02-26 | 公開日 | 2004-02-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. J.Biol.Chem., 278, 2003
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7VZM
| Anti-CRISPR AcrIE4-F7 | 分子名称: | AcrIE4-F7 | 著者 | Hong, S.H, Lee, G, Bae, E, Suh, J.Y. | 登録日 | 2021-11-16 | 公開日 | 2022-02-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The structure of AcrIE4-F7 reveals a common strategy for dual CRISPR inhibition by targeting PAM recognition sites. Nucleic Acids Res., 50, 2022
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4ZCA
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4ZHI
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