4I5P
| Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | 分子名称: | (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(1H-pyrrol-2-yl)-7,8-dihydropteridin-6(5H)-one, Serine/threonine-protein kinase PLK2 | 著者 | Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P. | 登録日 | 2012-11-28 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.738 Å) | 主引用文献 | Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
|
|
3OY1
| Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties | 分子名称: | 5-[2-(cyclohexylamino)pyridin-4-yl]-4-naphthalen-2-yl-2-(tetrahydro-2H-pyran-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, Mitogen-activated protein kinase 10 | 著者 | Probst, G.D, Bowers, S, Sealy, J.M, Truong, A, Neitz, J, Hom, R.K, Galemmo Jr, R.A, Konradi, A.W, Sham, H.L, Quincy, D, Pan, H, Yao, N. | 登録日 | 2010-09-22 | 公開日 | 2011-08-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3PTG
| Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor | 分子名称: | C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10, N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | 著者 | Bowers, S, Truong, A.P, Neitz, J, Neitzel, M, Probst, G.D, Hom, R.K, Konradi, A.W, Sham, H.L, Toth, G, Pan, H, Yao, N, Artis, D.R, Brigham, E.F, Quinn, K.P, Sauer, J, Powell, K, Ruslim, L, Bard, F, Yednock, T.A, Griswold-Prenner, I. | 登録日 | 2010-12-02 | 公開日 | 2011-03-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg.Med.Chem.Lett., 21, 2011
|
|
4I11
| Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. | 分子名称: | Beta-secretase 1, N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-phenylalanine, ZINC ION | 著者 | Bowers, B, Xu, Y, Yuan, S, Probst, G.D, Hom, R.K, Chan, W, Konradi, A.W, Sham, H.L, Zhu, Y.L, Beroza, P, Pan, H, Brecht, E, Yao, N, Lougheed, J, Artis, D.R, Tam, D, Bova, M. | 登録日 | 2012-11-19 | 公開日 | 2013-03-06 | 最終更新日 | 2013-04-24 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bioorg.Med.Chem.Lett., 23, 2013
|
|
6L30
| Crystal structure of the epithelial cell transforming 2 (ECT2) | 分子名称: | Protein ECT2 | 著者 | Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. | 登録日 | 2019-10-07 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
4R1T
| Crystal structure of Petunia hydrida cinnamoyl-CoA reductase | 分子名称: | cinnamoyl CoA reductase, molecular iodine | 著者 | Noel, J.P, Louie, G.V, Bowman, M.E, Bomati, E.K. | 登録日 | 2014-08-07 | 公開日 | 2014-10-01 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell, 26, 2014
|
|
4R1U
| Crystal structure of Medicago truncatula cinnamoyl-CoA reductase | 分子名称: | ACETATE ION, Cinnamoyl CoA reductase | 著者 | Noel, J.P, Bomati, E.K, Louie, G.V, Bowman, M.E. | 登録日 | 2014-08-07 | 公開日 | 2014-10-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell, 26, 2014
|
|
4R1S
| Crystal structure of Petunia hydrida cinnamoyl-CoA reductase | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, cinnamoyl CoA reductase | 著者 | Noel, J.P, Louie, G.V, Bowman, M.E, Bomati, E.K. | 登録日 | 2014-08-07 | 公開日 | 2014-10-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell, 26, 2014
|
|
3MFE
| |
3MKA
| |
3MI0
| Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A | 分子名称: | (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-4-ethyl-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carbaldehyde, DIMETHYLFORMAMIDE, Proteasome subunit alpha, ... | 著者 | Li, D, Li, H. | 登録日 | 2010-04-09 | 公開日 | 2010-06-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome. Embo J., 2010
|
|
1IJL
| Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus | 分子名称: | CALCIUM ION, PHOSPHOLIPASE A2, ZINC ION | 著者 | Gu, L, Zhang, H, Song, S, Zhou, Y, Lin, Z. | 登録日 | 2001-04-27 | 公開日 | 2001-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus. Acta Crystallogr.,Sect.D, 58, 2002
|
|
8TWQ
| |
5U1M
| |
7K3Y
| |
7K3C
| SGMGGIT segment 58-64 from Keratin-8 | 分子名称: | ETHANOL, SGMGGIT segment 58-64 from the low complexity domain of Keratin-8, TRIETHYLENE GLYCOL | 著者 | Murray, K.A, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2020-09-11 | 公開日 | 2021-11-10 | 最終更新日 | 2022-07-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat.Struct.Mol.Biol., 29, 2022
|
|
7K3X
| |
3HBF
| Structure of UGT78G1 complexed with myricetin and UDP | 分子名称: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, Flavonoid 3-O-glucosyltransferase, URIDINE-5'-DIPHOSPHATE | 著者 | Wang, X, Modolo, L, Li, L, Dixon, R. | 登録日 | 2009-05-04 | 公開日 | 2009-09-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids. J.Mol.Biol., 392, 2009
|
|
3HBJ
| Structure of UGT78G1 complexed with UDP | 分子名称: | Flavonoid 3-O-glucosyltransferase, URIDINE-5'-DIPHOSPHATE | 著者 | Wang, X, Modolo, L, Li, L, Dixon, R. | 登録日 | 2009-05-04 | 公開日 | 2009-09-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids. J.Mol.Biol., 392, 2009
|
|
8EPA
| |
8FQ7
| Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | 分子名称: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | 著者 | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | 登録日 | 2023-01-05 | 公開日 | 2023-10-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
2AXY
| Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA | 分子名称: | C-rich strand of human telomeric dna, Poly(rC)-binding protein 2 | 著者 | Du, Z, Lee, J.K, Tjhen, R.J, Li, S, Stroud, R.M, James, T.L. | 登録日 | 2005-09-06 | 公開日 | 2005-09-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of the First KH Domain of Human Poly(C)-binding Protein-2 in Complex with a C-rich Strand of Human Telomeric DNA at 1.7 A J.Biol.Chem., 280, 2005
|
|
3N4L
| BACE-1 in complex with ELN380842 | 分子名称: | Beta-secretase 1, N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(1H-pyrazol-1-yl)phenyl]cyclohexyl}amino)propyl]acetamide | 著者 | Yao, N.H. | 登録日 | 2010-05-21 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. Bioorg.Med.Chem.Lett., 20, 2010
|
|
3NSH
| BACE-1 in complex with ELN475957 | 分子名称: | Beta-secretase 1, N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({1-[4-(2,2-dimethylpropyl)thiophen-2-yl]cyclopropyl}amino)-2-hydroxypropyl]acetamide | 著者 | Probst, G.D, Bowers, S, Sealy, J.M, Brecht, E, Yao, N. | 登録日 | 2010-07-01 | 公開日 | 2010-09-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. Bioorg.Med.Chem.Lett., 20, 2010
|
|
4ES4
| Crystal structure of YdiV and FlhD complex | 分子名称: | Flagellar transcriptional regulator FlhD, Putative cyclic di-GMP regulator CdgR | 著者 | Li, B, Gu, L. | 登録日 | 2012-04-22 | 公開日 | 2012-10-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility Nucleic Acids Res., 40, 2012
|
|