3OY1
Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties
Summary for 3OY1
Entry DOI | 10.2210/pdb3oy1/pdb |
Descriptor | Mitogen-activated protein kinase 10, 5-[2-(cyclohexylamino)pyridin-4-yl]-4-naphthalen-2-yl-2-(tetrahydro-2H-pyran-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one (3 entities in total) |
Functional Keywords | kinase inhibitor, cns, selectivity, transferase, transherase-transferase inhibitor complex, transherase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42268.94 |
Authors | Probst, G.D.,Bowers, S.,Sealy, J.M.,Truong, A.,Neitz, J.,Hom, R.K.,Galemmo Jr., R.A.,Konradi, A.W.,Sham, H.L.,Quincy, D.,Pan, H.,Yao, N. (deposition date: 2010-09-22, release date: 2011-08-17, Last modification date: 2024-02-21) |
Primary citation | Probst, G.D.,Bowers, S.,Sealy, J.M.,Truong, A.P.,Hom, R.K.,Galemmo, R.A.,Konradi, A.W.,Sham, H.L.,Quincy, D.A.,Pan, H.,Yao, N.,Lin, M.,Toth, G.,Artis, D.R.,Zmolek, W.,Wong, K.,Qin, A.,Lorentzen, C.,Nakamura, D.F.,Quinn, K.P.,Sauer, J.M.,Powell, K.,Ruslim, L.,Wright, S.,Chereau, D.,Ren, Z.,Anderson, J.P.,Bard, F.,Yednock, T.A.,Griswold-Prenner, I. Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg.Med.Chem.Lett., 21:315-319, 2011 Cited by PubMed: 21112785DOI: 10.1016/j.bmcl.2010.11.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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