1A3G
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![BU of 1a3g by Molmil](/molmil-images/mine/1a3g) | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE FROM ESCHERICHIA COLI | Descriptor: | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Okada, K, Hirotsu, K, Sato, M, Hayashi, H, Kagamiyama, H. | Deposit date: | 1998-01-21 | Release date: | 1998-05-27 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three-dimensional structure of Escherichia coli branched-chain amino acid aminotransferase at 2.5 A resolution. J.Biochem.(Tokyo), 121, 1997
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1I1L
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![BU of 1i1l by Molmil](/molmil-images/mine/1i1l) | CRYSTAL STRUCTURE OF ESCHELICHIA COLI BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE. | Descriptor: | 2-METHYLLEUCINE, BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Okada, K, Hirotsu, K, Hayashi, H, Kagamiyama, H. | Deposit date: | 2001-02-02 | Release date: | 2001-07-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme. Biochemistry, 40, 2001
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1I1K
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![BU of 1i1k by Molmil](/molmil-images/mine/1i1k) | CRYSTAL STRUCTURE OF ESCHELICHIA COLI BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE. | Descriptor: | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Okada, K, Hirotsu, K, Hayashi, H, Kagamiyama, H. | Deposit date: | 2001-02-02 | Release date: | 2001-07-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme. Biochemistry, 40, 2001
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1I1M
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![BU of 1i1m by Molmil](/molmil-images/mine/1i1m) | CRYSTAL STRUCTURE OF ESCHERICHIA COLI BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE. | Descriptor: | 4-METHYL VALERIC ACID, BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Okada, K, Hirotsu, K, Hayashi, H, Kagamiyama, H. | Deposit date: | 2001-02-02 | Release date: | 2001-07-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme. Biochemistry, 40, 2001
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2F87
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![BU of 2f87 by Molmil](/molmil-images/mine/2f87) | Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus | Descriptor: | SRP RNA | Authors: | Okada, K, Takahashi, M, Sakamoto, T, Nakamura, K, Kanai, A, Kawai, G | Deposit date: | 2005-12-02 | Release date: | 2006-08-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus Nucleosides Nucleotides Nucleic Acids, 25, 2006
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3WX9
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![BU of 3wx9 by Molmil](/molmil-images/mine/3wx9) | Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with PMP, GLA, 4AD, 2OG, GLU and KYA | Descriptor: | (2E)-pent-2-enedioic acid, 2-OXOGLUTARIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Okada, K, Angkawidjaja, C, Koga, Y, Kanaya, S. | Deposit date: | 2014-07-28 | Release date: | 2014-09-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with PMP, GLA, 4AD, 2OG, GLU and KYA To be Published
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3ATH
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![BU of 3ath by Molmil](/molmil-images/mine/3ath) | Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with four AKGs as substrates and allosteric effectors | Descriptor: | 2-OXOGLUTARIC ACID, PYRIDOXAL-5'-PHOSPHATE, Putative uncharacterized protein PH0207 | Authors: | Okada, K, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | Deposit date: | 2011-01-05 | Release date: | 2012-01-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Characterization of kynurenine aminotransferase from hyperthermophilic archaeon: enzymatic activity for conversion to kynurenic acid is allosterically regulated by alpha-ketoglutaric acid cooperatively with kynurenine To be Published
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3AV7
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![BU of 3av7 by Molmil](/molmil-images/mine/3av7) | Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with PMP, KYN as substrates and KYA as products | Descriptor: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-hydroxyquinoline-2-carboxylic acid, ... | Authors: | Okada, K, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | Deposit date: | 2011-02-23 | Release date: | 2012-03-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural insight into kynurenic acid excretion mechanisms of kynurenine aminotransferase in the hyperthermophilic archaeon Pyrococcus horikoshii To be Published
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3AOW
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![BU of 3aow by Molmil](/molmil-images/mine/3aow) | Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with AKG | Descriptor: | 2-OXOGLUTARIC ACID, PYRIDOXAL-5'-PHOSPHATE, Putative uncharacterized protein PH0207 | Authors: | Okada, K, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | Deposit date: | 2010-10-07 | Release date: | 2011-10-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Characterization of kynurenine aminotransferase from hyperthermophilic archaeon: enzymatic activity for conversion to kynurenic acid is allosterically regulated by alpha-ketoglutaric acid cooperatively with kynurenine To be Published
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3AOV
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![BU of 3aov by Molmil](/molmil-images/mine/3aov) | Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with PLP | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Putative uncharacterized protein PH0207 | Authors: | Okada, K, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | Deposit date: | 2010-10-07 | Release date: | 2011-10-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Characterization of kynurenine aminotransferase from hyperthermophilic archaeon: enzymatic activity for conversion to kynurenic acid is allosterically regulated by alpha-ketoglutaric acid cooperatively with kynurenine To be Published
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2Z04
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![BU of 2z04 by Molmil](/molmil-images/mine/2z04) | Crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit from Aquifex aeolicus | Descriptor: | Phosphoribosylaminoimidazole carboxylase ATPase subunit, SULFATE ION | Authors: | Okada, K, Tamura, S, Baba, S, Kanagawa, M, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-06 | Release date: | 2007-11-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit from Aquifex aeolicus To be Published
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3AW8
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![BU of 3aw8 by Molmil](/molmil-images/mine/3aw8) | Crystal structure of N5-carboxyaminoimidazole ribonucleotide synthetase from Thermus thermophilus HB8 | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Phosphoribosylaminoimidazole carboxylase, ... | Authors: | Okada, K, Tsunoda, S, Taka, H, Baba, S, Kanagawa, M, Nakagawa, N, Ebihara, A, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2011-03-15 | Release date: | 2012-04-11 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of N5-carboxyaminoimidazole ribonucleotide synthetase, PurK, from thermophilic bacteria To be Published
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2FYH
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![BU of 2fyh by Molmil](/molmil-images/mine/2fyh) | Solution structure of the 2'-5' RNA ligase-like protein from Pyrococcus furiosus | Descriptor: | putative integral membrane transport protein | Authors: | Okada, K, Matsuda, T, Sakamoto, T, Muto, Y, Yokoyama, S, Kanai, A, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-02-08 | Release date: | 2007-02-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus Rna, 15, 2009
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5VAD
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![BU of 5vad by Molmil](/molmil-images/mine/5vad) | Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor | Descriptor: | 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ... | Authors: | Okada, K, Skene, R.J. | Deposit date: | 2017-03-24 | Release date: | 2017-05-31 | Last modified: | 2017-06-07 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline. Biochem. Biophys. Res. Commun., 488, 2017
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6JZJ
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![BU of 6jzj by Molmil](/molmil-images/mine/6jzj) | Structure of FimA type-2 (FimA2) prepilin of the type V major fimbrium | Descriptor: | Major fimbrium subunit FimA type-2, SULFATE ION | Authors: | Okada, K, Shoji, M, Nakayam, K, Imada, K. | Deposit date: | 2019-05-02 | Release date: | 2020-04-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange. Nat Microbiol, 5, 2020
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6JZK
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![BU of 6jzk by Molmil](/molmil-images/mine/6jzk) | Structure of FimA type-1 (FimA1) prepilin of the type V major fimbrium | Descriptor: | GLYCEROL, Major fimbrium subunit FimA type-1, S,R MESO-TARTARIC ACID, ... | Authors: | Okada, K, Shoji, M, Nakayam, K, Imada, K. | Deposit date: | 2019-05-02 | Release date: | 2020-04-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange. Nat Microbiol, 5, 2020
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5WJJ
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![BU of 5wjj by Molmil](/molmil-images/mine/5wjj) | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | Descriptor: | Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide | Authors: | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | Deposit date: | 2017-07-23 | Release date: | 2018-01-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
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4PHU
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![BU of 4phu by Molmil](/molmil-images/mine/4phu) | Crystal structure of Human GPR40 bound to allosteric agonist TAK-875 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DIMETHYL SULFOXIDE, Free fatty acid receptor 1,Lysozyme, ... | Authors: | Srivastava, A, Yano, J.K, Hirozane, Y, Kefala, G, Snell, G, Lane, W, Gruswitz, F, Ivetac, A, Aertgeerts, K, Nguyen, J, Jennings, A, Okada, K. | Deposit date: | 2014-05-07 | Release date: | 2014-07-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.332 Å) | Cite: | High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature, 513, 2014
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3VW8
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![BU of 3vw8 by Molmil](/molmil-images/mine/3vw8) | Crystal structure of human c-Met kinase domain with its inhibitor | Descriptor: | CHLORIDE ION, Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | Authors: | Matsumoto, S, Miyamoto, N, Hirayama, T, Oki, H, Okada, K, Tawada, M, Iwata, H, Miki, H, Nakamura, K, Hori, A, Imamura, S. | Deposit date: | 2012-08-08 | Release date: | 2013-08-14 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors. Bioorg.Med.Chem., 21, 2013
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3VO3
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![BU of 3vo3 by Molmil](/molmil-images/mine/3vo3) | Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative | Descriptor: | 1,2-ETHANEDIOL, N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide, Vascular endothelial growth factor receptor 2 | Authors: | Oki, H, Okada, K. | Deposit date: | 2012-01-19 | Release date: | 2013-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor Bioorg.Med.Chem., 21, 2013
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6ANL
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![BU of 6anl by Molmil](/molmil-images/mine/6anl) | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | Descriptor: | Mitogen-activated protein kinase 14, TAK-715 | Authors: | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | Deposit date: | 2017-08-14 | Release date: | 2018-01-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
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6M9L
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![BU of 6m9l by Molmil](/molmil-images/mine/6m9l) | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10 | Descriptor: | 3-benzyl-6-[(2,4-difluorophenyl)amino]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, Mitogen-activated protein kinase 14 | Authors: | Lane, W, Okada, K. | Deposit date: | 2018-08-23 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
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3VHE
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![BU of 3vhe by Molmil](/molmil-images/mine/3vhe) | Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor. | Descriptor: | 1-{2-fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Vascular endothelial growth factor receptor 2 | Authors: | Oguro, Y, Miyamoto, N, Okada, K, Takagi, T, Iwata, H, Awazu, Y, Miki, H, Hori, A, Kamiyama, K, Imanura, S. | Deposit date: | 2011-08-24 | Release date: | 2011-11-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation. Bioorg.Med.Chem., 18, 2010
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6M95
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![BU of 6m95 by Molmil](/molmil-images/mine/6m95) | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1 | Descriptor: | (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl)phenyl]methanone, Mitogen-activated protein kinase 14 | Authors: | Lane, W, Okada, K. | Deposit date: | 2018-08-22 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
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2HI7
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![BU of 2hi7 by Molmil](/molmil-images/mine/2hi7) | Crystal structure of DsbA-DsbB-ubiquinone complex | Descriptor: | Disulfide bond formation protein B, Thiol:disulfide interchange protein dsbA, UBIQUINONE-1, ... | Authors: | Inaba, K, Murakami, S, Suzuki, M, Nakagawa, A, Yamashita, E, Okada, K, Ito, K. | Deposit date: | 2006-06-29 | Release date: | 2006-12-05 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Crystal Structure of the DsbB-DsbA Complex Reveals a Mechanism of Disulfide Bond Generation Cell(Cambridge,Mass.), 127, 2006
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