3ATH
Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with four AKGs as substrates and allosteric effectors
Summary for 3ATH
Entry DOI | 10.2210/pdb3ath/pdb |
Related | 3AOV 3AOW |
Descriptor | Putative uncharacterized protein PH0207, PYRIDOXAL-5'-PHOSPHATE, 2-OXOGLUTARIC ACID, ... (4 entities in total) |
Functional Keywords | cofactor-substrate-allosteric effector complex, aminotransferase, plp binding, 2og binding, transamination, cytosol, transferase |
Biological source | Pyrococcus horikoshii |
Total number of polymer chains | 2 |
Total formula weight | 103404.47 |
Authors | Okada, K.,Angkawidjaja, C.,Koga, Y.,Takano, K.,Kanaya, S. (deposition date: 2011-01-05, release date: 2012-01-18, Last modification date: 2023-11-01) |
Primary citation | Okada, K.,Angkawidjaja, C.,Koga, Y.,Takano, K.,Kanaya, Y. Characterization of kynurenine aminotransferase from hyperthermophilic archaeon: enzymatic activity for conversion to kynurenic acid is allosterically regulated by alpha-ketoglutaric acid cooperatively with kynurenine To be Published, |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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