2RRC
 
 | | Solution Structure of RNA aptamer against AML1 Runt domain | | 分子名称: | 5'-R(P*GP*GP*AP*CP*CP*CP*(AP7)P*CP*CP*AP*CP*GP*GP*CP*GP*AP*GP*GP*UP*CP*CP*A)-3' | | 著者 | Nomura, Y, Fujiwara, K, Chiba, M, Fukunaga, J, Tanaka, Y, Iibuchi, H, Tanaka, T, Nakamura, Y, Kawai, G, Kozu, T, Sakamoto, T. | | 登録日 | 2010-06-23 | | 公開日 | 2011-06-29 | | 最終更新日 | 2020-02-26 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A novel high affinity RNA motif that mimics DNA in AML1 Runt domain binding
To be Published
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2FDT
 | | Solution structure of a conserved RNA hairpin of eel LINE UnaL2 | | 分子名称: | 36-mer | | 著者 | Nomura, Y, Baba, S, Nakazato, S, Sakamoto, T, Kajikawa, M, Okada, N, Kawai, G. | | 登録日 | 2005-12-14 | | 公開日 | 2006-12-05 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and functional importance of a conserved RNA hairpin of eel LINE UnaL2
Nucleic Acids Res., 34, 2006
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3AGV
 | | Crystal structure of a human IgG-aptamer complex | | 分子名称: | 5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3', CALCIUM ION, Ig gamma-1 chain C region, ... | | 著者 | Nomura, Y, Sugiyama, S, Sakamoto, T, Miyakawa, S, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Nakamura, Y, Matsumura, H. | | 登録日 | 2010-04-08 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex
Nucleic Acids Res., 38, 2010
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6D2Z
 | | Structure of human Usb1 with uridine-adenosine, inactive H208Q mutant | | 分子名称: | 5'-R(UP*A)-3'), CHLORIDE ION, U6 snRNA phosphodiesterase | | 著者 | Nomura, Y, Montemayor, E.J, Butcher, S.E. | | 登録日 | 2018-04-14 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1.
Nucleic Acids Res., 46, 2018
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6D30
 | | Structure of human Usb1 with uridine-uridine, inactive H208Q mutant | | 分子名称: | CHLORIDE ION, RNA (5'-R(UP*U)-3'), U6 snRNA phosphodiesterase | | 著者 | Nomura, Y, Montemayor, E.J, Butcher, S.E. | | 登録日 | 2018-04-14 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1.
Nucleic Acids Res., 46, 2018
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6PFQ
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6PGL
 | | Structure of Kluyveromyces marxianus Usb1 with uridine monophosphate | | 分子名称: | 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, GLYCEROL, ... | | 著者 | Nomura, Y, Montemayor, E.J, Butcher, S.E. | | 登録日 | 2019-06-24 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | | 主引用文献 | Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1.
Nucleic Acids Res., 48, 2020
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6D31
 | | Structure of human Usb1 with adenosine 5'-monophosphate | | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Nomura, Y, Montemayor, E.J, Butcher, S.E. | | 登録日 | 2018-04-14 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1.
Nucleic Acids Res., 46, 2018
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4U6K
 | | Crystal structure of DNA/RNA duplex containing 2'-4'-BNA-NC | | 分子名称: | COBALT HEXAMMINE(III), DNA (5'-D(*(NCU)P*(NTT)P*CP*TP*TP*CP*TP*(NTT)P*(NCU))-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3') | | 著者 | Kondo, J, Nomura, Y, Kitahara, Y, Obika, S, Torigoe, H. | | 登録日 | 2014-07-29 | | 公開日 | 2015-08-19 | | 最終更新日 | 2022-07-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
Chem.Commun.(Camb.), 52, 2016
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4U6M
 | | Crystal structure of DNA/RNA duplex obtained in the presence of Spermine | | 分子名称: | DNA (5'-D(*(5CM)P*TP*CP*TP*TP*CP*TP*TP*(5CM))-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3') | | 著者 | Kondo, J, Nomura, Y, Kitahara, Y, Obika, S, Torigoe, H. | | 登録日 | 2014-07-29 | | 公開日 | 2015-08-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
Chem.Commun.(Camb.), 52, 2016
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4U6L
 | | Crystal structure of DNA/RNA duplex obtained in the presence of [Co(NH3)6]Cl3 and SrCl2 | | 分子名称: | COBALT HEXAMMINE(III), DNA (5'-D(*(5CM)P*TP*CP*TP*TP*CP*TP*TP*(5CM))-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3'), ... | | 著者 | Kondo, J, Nomura, Y, Kitahara, Y, Obika, S, Torigoe, H. | | 登録日 | 2014-07-29 | | 公開日 | 2015-08-19 | | 最終更新日 | 2022-07-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
Chem.Commun.(Camb.), 52, 2016
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7MKT
 | | Crystal structure of r(GU)11G-NMM complex | | 分子名称: | N-METHYLMESOPORPHYRIN, POTASSIUM ION, RNA (5'-R(*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*G)-3') | | 著者 | Bingman, C.A, Roschdi, S, Nomura, Y, Butcher, S.E. | | 登録日 | 2021-04-26 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-02-08 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | An atypical RNA quadruplex marks RNAs as vectors for gene silencing.
Nat.Struct.Mol.Biol., 29, 2022
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3E54
 | | Archaeal Intron-encoded Homing Endonuclease I-Vdi141I Complexed With DNA | | 分子名称: | DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DGP*DGP*DCP*DTP*DAP*DCP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DAP*DGP*DAP*DGP*DTP*DCP*DAP*DG)-3'), ... | | 著者 | Nomura, N, Nomura, Y, Sussman, D, Stoddard, B.L. | | 登録日 | 2008-08-13 | | 公開日 | 2008-12-30 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases
Nucleic Acids Res., 36, 2008
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5YOY
 | | Crystal structure of the human tumor necrosis factor in complex with golimumab Fv | | 分子名称: | Golimumab heavy chain variable region, Golimumab light chain variable region, Tumor necrosis factor | | 著者 | Ono, M, Horita, S, Sato, Y, Nomura, Y, Iwata, S, Nomura, N. | | 登録日 | 2017-10-31 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.727 Å) | | 主引用文献 | Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab
Protein Sci., 27, 2018
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6A94
 | | Crystal structure of 5-HT2AR in complex with zotepine | | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | | 著者 | Kimura, T.K, Asada, H, Inoue, A, Kadji, F.M.N, Im, D, Mori, C, Arakawa, T, Hirata, K, Nomura, Y, Nomura, N, Aoki, J, Iwata, S, Shimamura, T. | | 登録日 | 2018-07-11 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
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6A93
 | | Crystal structure of 5-HT2AR in complex with risperidone | | 分子名称: | 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | | 著者 | Kimura, T.K, Asada, H, Inoue, A, Kadji, F.M.N, Im, D, Mori, C, Arakawa, T, Hirata, K, Nomura, Y, Nomura, N, Aoki, J, Iwata, S, Shimamura, T. | | 登録日 | 2018-07-11 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
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4YBQ
 | | Rat GLUT5 with Fv in the outward-open form | | 分子名称: | Solute carrier family 2, facilitated glucose transporter member 5, antibody Fv fragment heavy chain, ... | | 著者 | Nomura, N, Shimamura, T, Iwata, S. | | 登録日 | 2015-02-19 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Structure and mechanism of the mammalian fructose transporter GLUT5
Nature, 526, 2015
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4YB9
 | | Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation | | 分子名称: | Solute carrier family 2, facilitated glucose transporter member 5 | | 著者 | Verdon, G, Kang, H.J, Iwata, S, Drew, D. | | 登録日 | 2015-02-18 | | 公開日 | 2015-10-14 | | 最終更新日 | 2017-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure and mechanism of the mammalian fructose transporter GLUT5.
Nature, 526, 2015
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5B8C
 | | High resolution structure of the human PD-1 in complex with pembrolizumab Fv | | 分子名称: | Pembrolizumab heavy chain variable region (PemVH), Pembrolizumab light chain variable region (PemVL), Programmed cell death protein 1 | | 著者 | Horita, S, Shimamura, T, Iwata, S, Nomura, N. | | 登録日 | 2016-06-14 | | 公開日 | 2016-10-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.146 Å) | | 主引用文献 | High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1
Sci Rep, 6, 2016
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5AYG
 | | Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g | | 分子名称: | 3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-yl-propanamide, Nuclear receptor ROR-gamma | | 著者 | Noguchi, M, Doi, S, Nomura, A, Kikuwaka, M, Murase, K, Hirata, K, Kamada, M, Adachi, T. | | 登録日 | 2015-08-20 | | 公開日 | 2016-03-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Acs Med.Chem.Lett., 7, 2016
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7VAE
 | | Cryo-EM structure of bovine NTCP complexed with YN69202Fab | | 分子名称: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ... | | 著者 | Asami, J, Shimizu, T, Ohto, U. | | 登録日 | 2021-08-29 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
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7VAF
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7VAD
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7VAG
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7WSI
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