1ERQ
| X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID | 分子名称: | 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE | 著者 | Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J. | 登録日 | 2000-04-06 | 公開日 | 2000-05-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,). Biochemistry, 39, 2000
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1ERO
| X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID | 分子名称: | (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE | 著者 | Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J. | 登録日 | 2000-04-06 | 公開日 | 2000-05-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,). Biochemistry, 39, 2000
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1ERM
| X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHANE BORONIC ACID | 分子名称: | 1(R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE | 著者 | Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J. | 登録日 | 2000-04-06 | 公開日 | 2000-05-10 | 最終更新日 | 2012-06-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,). Biochemistry, 39, 2000
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1YM4
| Crystal structure of human beta secretase complexed with NVP-AMK640 | 分子名称: | Beta-secretase 1, NVP-AMK640 INHIBITOR | 著者 | Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S. | 登録日 | 2005-01-20 | 公開日 | 2006-01-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics J.Med.Chem., 48, 2005
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1YM2
| Crystal structure of human beta secretase complexed with NVP-AUR200 | 分子名称: | Beta-secretase 1, NVP-AUR200 INHIBITOR | 著者 | Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S. | 登録日 | 2005-01-20 | 公開日 | 2006-01-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics J.Med.Chem., 48, 2005
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4PDQ
| Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog | 分子名称: | (2S)-4-amino-N-{(1R,2S,3R,4R,5S)-5-amino-3-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy }-4-[(2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranosyl)oxy]-2-hydroxycyclohexyl}-2-hydroxybutanamide, MAGNESIUM ION, RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3') | 著者 | Hanessian, S, Saavedra, O.M, Vilchis-Reyes, M.A, Maianti, J.P, Kanazawa, H, Dozzo, P, Feeney, L.A, Armstrong, E.S, Kondo, J. | 登録日 | 2014-04-21 | 公開日 | 2015-01-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs Chem Sci, 5, 2014
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1QF4
| DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE | 分子名称: | (C8-R)-HYDANTOCIDIN 5'-PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Hanessian, S, Lu, P.-P, Sanceau, J.-Y, Chemla, P, Gohda, K, Fonne-Pfister, R, Prade, L, Cowan-Jacob, S.W. | 登録日 | 1999-04-06 | 公開日 | 1999-12-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | An enzyme-bound bisubstrate hybrid inhibitor of adenylosuccinate synthetase Angew.Chem.Int.Ed.Engl., 38, 1999
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1RIW
| Thrombin in complex with natural product inhibitor Oscillarin | 分子名称: | (2R,3AS,6R,7AS)-N-(2-{1-[AMINO(IMINO)METHYL]-2,5-DIHYDRO-1H-PYRROL-3-YL}ETHYL)-6-HYDROXY-1-{N-[(2S)-2-HYDROXY-3-PHENYLPROPANOYL]PHENYLALANYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin IIB, ... | 著者 | Hanessian, S, Tremblay, M, Petersen, J.F.W. | 登録日 | 2003-11-18 | 公開日 | 2004-11-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin J.Am.Chem.Soc., 126, 2004
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1QF5
| DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE | 分子名称: | (C8-S)-HYDANTOCIDIN 5'-PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Hanessian, S, Lu, P.-P, Sanceau, J.-Y, Chemla, P, Prade, L, Gohda, K, Cowan-Jacob, S.W, Fonne-Pfister, R. | 登録日 | 1999-04-06 | 公開日 | 1999-12-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An enzyme-bound bisubstrate hybrid inhibitor of adenylosuccinate synthetase Angew.Chem.Int.Ed.Engl., 38, 1999
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3OJL
| Native structure of the UDP-N-acetyl-mannosamine dehydrogenase Cap5O from Staphylococcus aureus | 分子名称: | Cap5O, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Nessler, S, Gruszczyk, J, Olivares-Illana, V, Meyer, P, Morera, S, Grangeasse, C, Fleurie, A. | 登録日 | 2010-08-23 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure Analysis of the Staphylococcus aureus UDP-N-acetyl-mannosamine Dehydrogenase Cap5O Involved in Capsular Polysaccharide Biosynthesis. J.Biol.Chem., 286, 2011
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3OJO
| Derivative structure of the UDP-N-acetyl-mannosamine dehydrogenase Cap5O from S. aureus | 分子名称: | Cap5O, EUROPIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Nessler, S, Gruszczyk, J, Olivares-Illana, V, Meyer, P, Morera, S. | 登録日 | 2010-08-23 | 公開日 | 2011-03-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure Analysis of the Staphylococcus aureus UDP-N-acetyl-mannosamine Dehydrogenase Cap5O Involved in Capsular Polysaccharide Biosynthesis. J.Biol.Chem., 286, 2011
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6G4J
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8RWU
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8RXA
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8RXO
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6HU8
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6HUA
| the competence regulator ComR from Streptococcus vestibularis in complex with its cognate signaling peptide XIP | 分子名称: | Uncharacterized protein, XIP signaling peptide | 著者 | Nessler, S, Thuillier, J, Ledesma, L, Hols, P. | 登録日 | 2018-10-05 | 公開日 | 2019-10-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.389 Å) | 主引用文献 | Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci. Proc.Natl.Acad.Sci.USA, 117, 2020
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5DBK
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6QER
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2QMH
| structure of V267F mutant HprK/P | 分子名称: | HPr kinase/phosphorylase | 著者 | Chaptal, V, Vincent, F, Gueguen-Chaignon, V, Poncet, S, Deutscher, J, Nessler, S, Morera, S. | 登録日 | 2007-07-16 | 公開日 | 2007-09-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Analysis of the Bacterial HPr Kinase/Phosphorylase V267F Mutant Gives Insights into the Allosteric Regulation Mechanism of This Bifunctional Enzyme. J.Biol.Chem., 282, 2007
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2VED
| crystal structure of the chimerical mutant CapABK55M protein | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MEMBRANE PROTEIN CAPA1, ... | 著者 | Olivares-Illana, V, Meyer, P, Gueguen-Chaignon, V, Soulat, D, Deustcher, J, Cozzone, A.J, Morera, S, Grangeasse, C, Nessler, S. | 登録日 | 2007-10-19 | 公開日 | 2008-07-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Basis for the Regulation Mechanism of the Tyrosine Kinase Capb from Staphylococcus Aureus. Plos Biol., 6, 2008
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5JUF
| Crystal structure of the apo form of ComR from S. thermophilus. | 分子名称: | SULFATE ION, Transcriptional regulator | 著者 | Talagas, A, Fontaine, L, Ledesma, L, Li de la Sierra-Gallay, I, Hols, P, Nessler, S. | 登録日 | 2016-05-10 | 公開日 | 2016-10-26 | 最終更新日 | 2016-12-14 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS. PLoS Pathog., 12, 2016
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5Z1I
| Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-fluoro sisomicin | 分子名称: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(P*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | 著者 | Kanazawa, H, Hanessian, S, Kondo, J. | 登録日 | 2017-12-26 | 公開日 | 2018-05-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. ChemMedChem, 13, 2018
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3BFV
| crystal structure of the chimerical protein CapAB | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Membrane protein CapA1, ... | 著者 | Olivares-Illana, V, Meyer, P, Morera, S, Nessler, S. | 登録日 | 2007-11-23 | 公開日 | 2008-06-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis for the Regulation Mechanism of the Tyrosine Kinase CapB from Staphylococcus aureus. Plos Biol., 6, 2008
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5Z1H
| Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin | 分子名称: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | 著者 | Kanazawa, H, Hanessian, S, Kondo, J. | 登録日 | 2017-12-26 | 公開日 | 2018-05-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. ChemMedChem, 13, 2018
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