4PDQ

Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog

Summary for 4PDQ

• Entry DOI: 10.2210/pdb4pdq/pdb
• Descriptor: RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3'), MAGNESIUM ION, (2S)-4-amino-N-{(1R,2S,3R,4R,5S)-5-amino-3-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy }-4-[(2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranosyl)oxy]-2-hydroxycyclohexyl}-2-hydroxybutanamide, ... (4 entities in total)
• Functional Keywords: ribosome, aminoglycoside, rna-antibiotic complex, rna/antibiotic
• Biological source: synthetic
• Total number of polymer chains: 2
• Total formula weight: 15507.20

Authors

Hanessian, S.,Saavedra, O.M.,Vilchis-Reyes, M.A.,Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Feeney, L.A.,Armstrong, E.S.,Kondo, J. (deposition date: 2014-04-21, release date: 2015-01-07, Last modification date: 2024-03-20)

• Primary citation: Hanessian, S.,Saavedra, O.M.,Vilchis-Reyes, M.A.,Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Matias, R.D.,Serio, A.,Kondo, J.; Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs; Chem Sci, 5:4621-4632, 2014; DOI: 10.1039/C4SC01626B

Experimental method

X-RAY DIFFRACTION (3 Å)