5Z1I

Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-fluoro sisomicin

Summary for 5Z1I

• Entry DOI: 10.2210/pdb5z1i/pdb
• Related: 5Z1H
• Descriptor: RNA (5'-R(P*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (3 entities in total)
• Functional Keywords: rrna, aminoglycoside, rna
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 7224.60

Authors

Kanazawa, H.,Hanessian, S.,Kondo, J. (deposition date: 2017-12-26, release date: 2018-05-30, Last modification date: 2024-03-27)

• Primary citation: Kanazawa, H.,Saavedra, O.M.,Maianti, J.P.,Young, S.A.,Izquierdo, L.,Smith, T.K.,Hanessian, S.,Kondo, J.; Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.; ChemMedChem, 13:1541-1548, 2018; PubMed: 29766661; DOI: 10.1002/cmdc.201800166

Experimental method

X-RAY DIFFRACTION (1.903 Å)